Table 3 Open in new tab Multivariable...

DSF

DSB

TMT-A

TMT-B

BTA

HVLT-L

HVLT-D

HVLT-DI

rs10808746

AA (ref)

PDE7A

−0.25(0.19)*

−0.33(0.19)^**

0.03(0.21)^∆

0.14(0.23)^∆

0.04(0.21)^∆

0.27(0.21)^∆

0.32(0.21)*

−1.0(0.22)^∆

0.08(0.22)^∆

0.43(0.24)^**

0.46(0.26)^**

0.53(0.24)^**

0.54(0.25)^**

0.34(0.25)*

rs12219216

AA (ref)

SORCS1

0.35(0.22)*

0.46(0.25)^**

0.34(0.23)*

0.30(0.23)*

0.37(0.23)*

0.02(0.22)^∆

0.66(0.25)^∆

0.19(0.24)^∆

0.09(0.23)^∆

0.13(0.24)^∆

rs584007

AA (ref)

APOE

0.07(0.24)^∆

0.60(0.26)^**

rs1143634

AA (ref)

IL-1

−0.38(0.23)

−0.38(0.23)^**

rs1474348

CC (ref)

IL-6

0.27(0.22)^∆

0.01(0.22)^∆

−0.10(0.25)^∆

0.03(0.24)^∆

0.02(0.24)^∆

0.04(0.24)^∆

0.32(0.22) ^∆

0.41(0.21)^**

0.47(0.25)^**

0.32(0.23)*

0.38(0.24)*

0.36(0.24)*

rs3764650

GT,G(ref)

ABCA7

119

0.32(0.23)*

−0.43(0.24)^**

rs8187858

CC (ref)

118

ABCC1

TC,TT

0.39(0.21)^**

Table 3

Open in new tab

Multivariable regression shrinkage analyses results: associations between LOAD/inflammation/cholesterol transport SNPs and cognitive test z-scores

		N	DSF	DSB	TMT-A	TMT-B	BTA	VF	HVLT-L	HVLT-D	HVLT-DI
rs10808746	AA (ref)	40
*PDE7A*	AG	78	−0.25(0.19)*	−0.33(0.19)^**	0.03(0.21)^∆	0.14(0.23)^∆			0.04(0.21)^∆	0.27(0.21)^∆	0.32(0.21)*
	GG	32	−1.0(0.22)^∆	0.08(0.22)^∆	0.43(0.24)^**	0.46(0.26)^**			0.53(0.24)^**	0.54(0.25)^**	0.34(0.25)*
rs12219216	AA (ref)	28
*SORCS1*	AG	68			0.35(0.22)*	0.46(0.25)^**		0.34(0.23)*	0.30(0.23)*	0.37(0.23)*
	GG	54			0.02(0.22)^∆	0.66(0.25)^∆		0.19(0.24)^∆	0.09(0.23)^∆	0.13(0.24)^∆
rs584007	AA (ref)	26
*APOE*	AG	66						0.07(0.24)^∆
	GG	58						0.60(0.26)^**
rs1143634	AA (ref)	65
*IL-1*	AG	85						−0.38(0.23)		−0.38(0.23)^**
rs1474348	CC (ref)	19
*IL-6*	GC	62	0.27(0.22)^∆	0.01(0.22)^∆		−0.10(0.25)^∆	0.03(0.24)^∆	0.02(0.24)^∆	0.04(0.24)^∆
	GG	69	0.32(0.22) ^∆	0.41(0.21)^**		0.47(0.25)^**	0.32(0.23)*	0.38(0.24)*	0.36(0.24)*
rs3764650	GT,G(ref)	31
*ABCA7*	TT	119			0.32(0.23)*						−0.43(0.24)^**
rs8187858	CC (ref)	118
*ABCC1*	TC,TT	32			0.39(0.21)^**

		N	DSF	DSB	TMT-A	TMT-B	BTA	VF	HVLT-L	HVLT-D	HVLT-DI
rs10808746	AA (ref)	40
*PDE7A*	AG	78	−0.25(0.19)*	−0.33(0.19)^**	0.03(0.21)^∆	0.14(0.23)^∆			0.04(0.21)^∆	0.27(0.21)^∆	0.32(0.21)*
	GG	32	−1.0(0.22)^∆	0.08(0.22)^∆	0.43(0.24)^**	0.46(0.26)^**			0.53(0.24)^**	0.54(0.25)^**	0.34(0.25)*
rs12219216	AA (ref)	28
*SORCS1*	AG	68			0.35(0.22)*	0.46(0.25)^**		0.34(0.23)*	0.30(0.23)*	0.37(0.23)*
	GG	54			0.02(0.22)^∆	0.66(0.25)^∆		0.19(0.24)^∆	0.09(0.23)^∆	0.13(0.24)^∆
rs584007	AA (ref)	26
*APOE*	AG	66						0.07(0.24)^∆
	GG	58						0.60(0.26)^**
rs1143634	AA (ref)	65
*IL-1*	AG	85						−0.38(0.23)		−0.38(0.23)^**
rs1474348	CC (ref)	19
*IL-6*	GC	62	0.27(0.22)^∆	0.01(0.22)^∆		−0.10(0.25)^∆	0.03(0.24)^∆	0.02(0.24)^∆	0.04(0.24)^∆
	GG	69	0.32(0.22) ^∆	0.41(0.21)^**		0.47(0.25)^**	0.32(0.23)*	0.38(0.24)*	0.36(0.24)*
rs3764650	GT,G(ref)	31
*ABCA7*	TT	119			0.32(0.23)*						−0.43(0.24)^**
rs8187858	CC (ref)	118
*ABCC1*	TC,TT	32			0.39(0.21)^**

∆, PAS < 0.90; *PAS ≥ 0.90; **PAS ≥ 0.95

DSF = Digit Span Forward; DSB = Digit Span Backward; TMT-B = Trail Making Test, Part B; BTA = Brief Test of Attention; VF = Verbal Fluency Test; HVLT-L = Hopkins Verbal Learning Test‒Learning; HVLT-D = Hopkins Verbal Learning Test‒Delayed Recall; HVLT-DI = Hopkins Verbal Learning Test‒Discrimination Index.

Beta and standard error values for 7 SNPs retained in the multivariate regression models, controlling for age, education, treatment with RT ± CT, time since treatment, and tumor location.

Blank cells indicate that the SNP was not associated with the given cognitive test. SNPs and cognitive tests showing very strong (PAS ≥ 0.95) and strong (PAS ≥ 0.90) associations are included.

For SNPs with 3 categories, the effects and standard error of both categories are included even if only one category had PAS ≥ 0.95.

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