| . | Hypervariable region . | |||||
|---|---|---|---|---|---|---|
| . | aa pos 8–9 . | aa pos 35–36 . | aa pos 55–56 . | aa pos 69 . | aa pos 76 . | aa pos 84–87 . |
| DPB1*01 similar group | ||||||
| DPB1*01:01 | VY | YA | AA | K | V | DEAV |
| DPB1*11:01 | VY | YA | AA | R | M | DEAV |
| DPB1*13:01 | VY | YA | AA | E | I | DEAV |
| DPB1*26:01 | VY | YA | AA | K | V | DEAV |
| DPB1*03 similar group | ||||||
| DPB1*03:01 | VY | FV | DE | K | V | DEAV |
| DPB1*06:01 | VY | FV | DE | E | M | DEAV |
| DPB1*09:01 | VH | FV | DE | E | V | DEAV |
| DPB1*10:01 | VH | FV | DE | E | V | DEAV |
| DPB1*14:01 | VH | FV | DE | K | V | DEAV |
| DPB1*17:01 | VH | FV | DE | E | M | DEAV |
| DPB1*20:01 | VY | FV | DE | K | M | DEAV |
| DPB1*25:01 | VY | FV | DE | K | V | DEAV |
| DPB1*05 similar group | ||||||
| DPB1*05:01 | LF | LV | EA | K | M | DEAV |
| DPB1*19:01 | LF | FV | EA | E | I | DEAV |
| DPB1*22:01 | LF | LV | EA | E | M | DEAV |
| DPB1*04 similar group | ||||||
| DPB1*04:01 | LF | FA | AA | K | M | GGPM |
| DPB1*04:02 | LF | FV | DE | K | M | GGPM |
| DPB1*23:01 | LF | FV | AA | K | M | GGPM |
| DPB1*02:01 | LF | FV | DE | E | M | GGPM |
| DPB1*02:02 | LF | LV | EA | E | M | GGPM |
| DPB1*24:01 | LF | FA | EA | K | M | GGPM |
| DPB1*15 similar group | ||||||
| DPB1*15:01 | VY | YA | AA | R | M | VGPM |
| DPB1*18:01 | VY | FV | DE | K | M | VGPM |
| . | Hypervariable region . | |||||
|---|---|---|---|---|---|---|
| . | aa pos 8–9 . | aa pos 35–36 . | aa pos 55–56 . | aa pos 69 . | aa pos 76 . | aa pos 84–87 . |
| DPB1*01 similar group | ||||||
| DPB1*01:01 | VY | YA | AA | K | V | DEAV |
| DPB1*11:01 | VY | YA | AA | R | M | DEAV |
| DPB1*13:01 | VY | YA | AA | E | I | DEAV |
| DPB1*26:01 | VY | YA | AA | K | V | DEAV |
| DPB1*03 similar group | ||||||
| DPB1*03:01 | VY | FV | DE | K | V | DEAV |
| DPB1*06:01 | VY | FV | DE | E | M | DEAV |
| DPB1*09:01 | VH | FV | DE | E | V | DEAV |
| DPB1*10:01 | VH | FV | DE | E | V | DEAV |
| DPB1*14:01 | VH | FV | DE | K | V | DEAV |
| DPB1*17:01 | VH | FV | DE | E | M | DEAV |
| DPB1*20:01 | VY | FV | DE | K | M | DEAV |
| DPB1*25:01 | VY | FV | DE | K | V | DEAV |
| DPB1*05 similar group | ||||||
| DPB1*05:01 | LF | LV | EA | K | M | DEAV |
| DPB1*19:01 | LF | FV | EA | E | I | DEAV |
| DPB1*22:01 | LF | LV | EA | E | M | DEAV |
| DPB1*04 similar group | ||||||
| DPB1*04:01 | LF | FA | AA | K | M | GGPM |
| DPB1*04:02 | LF | FV | DE | K | M | GGPM |
| DPB1*23:01 | LF | FV | AA | K | M | GGPM |
| DPB1*02:01 | LF | FV | DE | E | M | GGPM |
| DPB1*02:02 | LF | LV | EA | E | M | GGPM |
| DPB1*24:01 | LF | FA | EA | K | M | GGPM |
| DPB1*15 similar group | ||||||
| DPB1*15:01 | VY | YA | AA | R | M | VGPM |
| DPB1*18:01 | VY | FV | DE | K | M | VGPM |
The HLA-DPB1 alleles differ primarily at these six hypervariable regions. The DEAV motif at aa position 84–87 separates several alleles from the more frequent GGPM motif characterizing the HLA-DPB1*04:01, HLA-DPB1*04:02 and HLA-DPB1*23:01, as well as the HLA-DPB1*02:01 and HLA-DPB1*02:02 alleles. HLA-DPB1*04:01 and HLA-DPB1*04:02 differ at positions 36 and 55–56, whereas HLA-DPB1*23:01 differs from HLA-DPB1*04:01 at position 36. Similarly, HLA-DPB1*02:01 and HLA-DPB1*02:02 differ from HLA-DPB1*04:01, HLA-DPB1*04:02 and HLA-DPB1*23:01, primarily at position 69 by a substitution of the positively charged lysine to the negatively charged glutamic acid. Amino acid (aa) abbreviations: A: alanine; C: cysteine; D: aspartic acid; E: glutamic acid; F: phenylalanine; G: glycine; H: histidine; I: isoleucine; L: Leucine; K: Lysine; M: methionine; N: asparagine; P: proline; G: glutamine; R: arginine; S; serine; T: threonine; V: valine; W: tryptophan; Y: tyrosine; GGPM: glycine-glycine-proline-methionine.
| . | Hypervariable region . | |||||
|---|---|---|---|---|---|---|
| . | aa pos 8–9 . | aa pos 35–36 . | aa pos 55–56 . | aa pos 69 . | aa pos 76 . | aa pos 84–87 . |
| DPB1*01 similar group | ||||||
| DPB1*01:01 | VY | YA | AA | K | V | DEAV |
| DPB1*11:01 | VY | YA | AA | R | M | DEAV |
| DPB1*13:01 | VY | YA | AA | E | I | DEAV |
| DPB1*26:01 | VY | YA | AA | K | V | DEAV |
| DPB1*03 similar group | ||||||
| DPB1*03:01 | VY | FV | DE | K | V | DEAV |
| DPB1*06:01 | VY | FV | DE | E | M | DEAV |
| DPB1*09:01 | VH | FV | DE | E | V | DEAV |
| DPB1*10:01 | VH | FV | DE | E | V | DEAV |
| DPB1*14:01 | VH | FV | DE | K | V | DEAV |
| DPB1*17:01 | VH | FV | DE | E | M | DEAV |
| DPB1*20:01 | VY | FV | DE | K | M | DEAV |
| DPB1*25:01 | VY | FV | DE | K | V | DEAV |
| DPB1*05 similar group | ||||||
| DPB1*05:01 | LF | LV | EA | K | M | DEAV |
| DPB1*19:01 | LF | FV | EA | E | I | DEAV |
| DPB1*22:01 | LF | LV | EA | E | M | DEAV |
| DPB1*04 similar group | ||||||
| DPB1*04:01 | LF | FA | AA | K | M | GGPM |
| DPB1*04:02 | LF | FV | DE | K | M | GGPM |
| DPB1*23:01 | LF | FV | AA | K | M | GGPM |
| DPB1*02:01 | LF | FV | DE | E | M | GGPM |
| DPB1*02:02 | LF | LV | EA | E | M | GGPM |
| DPB1*24:01 | LF | FA | EA | K | M | GGPM |
| DPB1*15 similar group | ||||||
| DPB1*15:01 | VY | YA | AA | R | M | VGPM |
| DPB1*18:01 | VY | FV | DE | K | M | VGPM |
| . | Hypervariable region . | |||||
|---|---|---|---|---|---|---|
| . | aa pos 8–9 . | aa pos 35–36 . | aa pos 55–56 . | aa pos 69 . | aa pos 76 . | aa pos 84–87 . |
| DPB1*01 similar group | ||||||
| DPB1*01:01 | VY | YA | AA | K | V | DEAV |
| DPB1*11:01 | VY | YA | AA | R | M | DEAV |
| DPB1*13:01 | VY | YA | AA | E | I | DEAV |
| DPB1*26:01 | VY | YA | AA | K | V | DEAV |
| DPB1*03 similar group | ||||||
| DPB1*03:01 | VY | FV | DE | K | V | DEAV |
| DPB1*06:01 | VY | FV | DE | E | M | DEAV |
| DPB1*09:01 | VH | FV | DE | E | V | DEAV |
| DPB1*10:01 | VH | FV | DE | E | V | DEAV |
| DPB1*14:01 | VH | FV | DE | K | V | DEAV |
| DPB1*17:01 | VH | FV | DE | E | M | DEAV |
| DPB1*20:01 | VY | FV | DE | K | M | DEAV |
| DPB1*25:01 | VY | FV | DE | K | V | DEAV |
| DPB1*05 similar group | ||||||
| DPB1*05:01 | LF | LV | EA | K | M | DEAV |
| DPB1*19:01 | LF | FV | EA | E | I | DEAV |
| DPB1*22:01 | LF | LV | EA | E | M | DEAV |
| DPB1*04 similar group | ||||||
| DPB1*04:01 | LF | FA | AA | K | M | GGPM |
| DPB1*04:02 | LF | FV | DE | K | M | GGPM |
| DPB1*23:01 | LF | FV | AA | K | M | GGPM |
| DPB1*02:01 | LF | FV | DE | E | M | GGPM |
| DPB1*02:02 | LF | LV | EA | E | M | GGPM |
| DPB1*24:01 | LF | FA | EA | K | M | GGPM |
| DPB1*15 similar group | ||||||
| DPB1*15:01 | VY | YA | AA | R | M | VGPM |
| DPB1*18:01 | VY | FV | DE | K | M | VGPM |
The HLA-DPB1 alleles differ primarily at these six hypervariable regions. The DEAV motif at aa position 84–87 separates several alleles from the more frequent GGPM motif characterizing the HLA-DPB1*04:01, HLA-DPB1*04:02 and HLA-DPB1*23:01, as well as the HLA-DPB1*02:01 and HLA-DPB1*02:02 alleles. HLA-DPB1*04:01 and HLA-DPB1*04:02 differ at positions 36 and 55–56, whereas HLA-DPB1*23:01 differs from HLA-DPB1*04:01 at position 36. Similarly, HLA-DPB1*02:01 and HLA-DPB1*02:02 differ from HLA-DPB1*04:01, HLA-DPB1*04:02 and HLA-DPB1*23:01, primarily at position 69 by a substitution of the positively charged lysine to the negatively charged glutamic acid. Amino acid (aa) abbreviations: A: alanine; C: cysteine; D: aspartic acid; E: glutamic acid; F: phenylalanine; G: glycine; H: histidine; I: isoleucine; L: Leucine; K: Lysine; M: methionine; N: asparagine; P: proline; G: glutamine; R: arginine; S; serine; T: threonine; V: valine; W: tryptophan; Y: tyrosine; GGPM: glycine-glycine-proline-methionine.
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