Table 1.5.1
A functional classification of molecular mechanisms of glucocorticoid receptor function
Mechanism Examples

Positive action via GRE

Tyrosine aminotransferase

MMTV genome

Metallothionein IIA

Alanine aminotransferase

Negative action via GRE

Proopiomelanocortin

α-subunit

Prolactin

Interference with transcription factors (e.g. AP1)

Collagenase type I

Gelatinase

Mechanism Examples

Positive action via GRE

Tyrosine aminotransferase

MMTV genome

Metallothionein IIA

Alanine aminotransferase

Negative action via GRE

Proopiomelanocortin

α-subunit

Prolactin

Interference with transcription factors (e.g. AP1)

Collagenase type I

Gelatinase

GRE, glucocorticoid response element.

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