Table 1.5.2
Changes in mRNA isoforms in response to hormonal and other signals
Alternatively spliced mRNA Stimulus

Insulin receptor

Dexamethasone

Glucose

Insulin

Cal/CGRP

Dexamethasone

Protein kinase C β

Insulin

IGFI

Growth hormone

FGF-R

Cytokines

TNFα

2-aminopurine

PTP1B

PDGF, EGF, basic FGF

TNFβ , β-globin

src

Hac1

UPR

hPMCA2

Calcium

CD44

TPA, PDGF, IGFI

Concanavalin A

Fibronectin EIIIB (rat)

Insulin, via HRS

Fibronectin ED (human)

TGFβ1, vitamin D, retinoic acid

Kv3.1 channel

Basic FGF

Agrin

NGF

SRp20

Serum/cell cycle

Slo (K channel gene)

Hypophysectomy

Alternatively spliced mRNA Stimulus

Insulin receptor

Dexamethasone

Glucose

Insulin

Cal/CGRP

Dexamethasone

Protein kinase C β

Insulin

IGFI

Growth hormone

FGF-R

Cytokines

TNFα

2-aminopurine

PTP1B

PDGF, EGF, basic FGF

TNFβ , β-globin

src

Hac1

UPR

hPMCA2

Calcium

CD44

TPA, PDGF, IGFI

Concanavalin A

Fibronectin EIIIB (rat)

Insulin, via HRS

Fibronectin ED (human)

TGFβ1, vitamin D, retinoic acid

Kv3.1 channel

Basic FGF

Agrin

NGF

SRp20

Serum/cell cycle

Slo (K channel gene)

Hypophysectomy

CGRP, calcitonin gene-related protein; EGF, epidermal growth factor; FGF, fibroblast growth factor; HRS, hepatic serine-arginine protein 40 KD; IGF, insulin-like growth factor; NGF, nerve growth factor; PDGF, platelet-derived growth factor; TNF, tumour necrosis factor; TPA, tetradecanoyl phorbol acetate.

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