Table 1.6.3
Proposed viral triggers for endocrine autoimmune diseases
Virus Symptoms caused by virus Endocrine autoimmune disease/s affected

Adenovirus

Upper respiratory infections

GD

Coxsackie B virus

Gastrointestinal infections and in more extreme cases myocarditis and pericarditis

Type 1 diabetes

Hepatitis B

Liver inflammation

GD, HT

Hepatitis C

Liver inflammation

GD, type 1 diabetes

Human foamy virus

Asymptomatic

GD

Human T-cell leukaemia virus (HTLV)

T-cell leukaemia and T-cell lymphoma

GD

Parvovirus B19

Causes childhood exanthema

GD, HT, type 1 diabetes

Rotavirus

Infection of the gastrointestinal tract

Type 1 diabetes

Virus Symptoms caused by virus Endocrine autoimmune disease/s affected

Adenovirus

Upper respiratory infections

GD

Coxsackie B virus

Gastrointestinal infections and in more extreme cases myocarditis and pericarditis

Type 1 diabetes

Hepatitis B

Liver inflammation

GD, HT

Hepatitis C

Liver inflammation

GD, type 1 diabetes

Human foamy virus

Asymptomatic

GD

Human T-cell leukaemia virus (HTLV)

T-cell leukaemia and T-cell lymphoma

GD

Parvovirus B19

Causes childhood exanthema

GD, HT, type 1 diabetes

Rotavirus

Infection of the gastrointestinal tract

Type 1 diabetes

GD, Graves’ disease; HT, Hashimoto’s thyroiditis.

Adapted from Gough, SCL Simmonds, MJ. The HLA region and autoimmune disease: Associations and mechanisms of action. Curr Genomics, 2007; 8: 453–6 (16).

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