Table 2.3.1.2 Open in new tab Clinical... | Oxford Academic

Table 2.3.1.2

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Clinical features of hypopituitarism due to mutations in PROP1, POU1F1, LHX3, and LHX4

	PROP1	POU1F1	LHX3	LHX4
Growth hormone	Deficient	Deficient	Deficient	Deficient
Thyroid-stimulating hormone	Deficient	Deficient	Deficient	Deficient
Prolactin	Deficient	Deficient	Deficient	Normal
Luteinizing hormone/follicle-stimulating hormone	Deficient	Normal	Deficient	Normal
Adrenocorticotropic hormone	May evolve	Normal	Normal/Deficient	Deficient
Pituitary	APH, N, E	APH, N	APH, N, E	APH, EPP
Other	–	–	Short cervical spine, sensorineural deafness	Cerebellar abnormalities

	PROP1	POU1F1	LHX3	LHX4
Growth hormone	Deficient	Deficient	Deficient	Deficient
Thyroid-stimulating hormone	Deficient	Deficient	Deficient	Deficient
Prolactin	Deficient	Deficient	Deficient	Normal
Luteinizing hormone/follicle-stimulating hormone	Deficient	Normal	Deficient	Normal
Adrenocorticotropic hormone	May evolve	Normal	Normal/Deficient	Deficient
Pituitary	APH, N, E	APH, N	APH, N, E	APH, EPP
Other	–	–	Short cervical spine, sensorineural deafness	Cerebellar abnormalities

APH, anterior pituitary hypoplasia; E, enlarged; EPP, ectopic posterior pituitary; N, normal.