Table 3.1.4.1
Situations in which serum TSH alone can give a false or uncertain indication of thyroid status
Condition TSH Free T4 Free T3

Primary abnormality of TSH secretion

Pituitary–hypothalamic disturbance

L-N

L

Central TSH excess

N-H

H

H

Very low birth weight premature infants

L-N

L

L

Thyrotoxicosis

Subclinical

U

N

N

Early treatment

U

H-N-L

H-N-L

Hypothyroidism

Subclinical

H

N

Early treatment

H

L-N

TSH assay artefact

Euthyroid subject

H

N

N

Thyrotoxic subject

L-N-H

H

H

Medications

Dopamine

L

N

Glucocorticoids

L

N

Condition TSH Free T4 Free T3

Primary abnormality of TSH secretion

Pituitary–hypothalamic disturbance

L-N

L

Central TSH excess

N-H

H

H

Very low birth weight premature infants

L-N

L

L

Thyrotoxicosis

Subclinical

U

N

N

Early treatment

U

H-N-L

H-N-L

Hypothyroidism

Subclinical

H

N

Early treatment

H

L-N

TSH assay artefact

Euthyroid subject

H

N

N

Thyrotoxic subject

L-N-H

H

H

Medications

Dopamine

L

N

Glucocorticoids

L

N

N, normal; L, low; H, high; U, undetectable.

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