| Population treated with GH . | Title . | Equation model . | Reference . |
|---|---|---|---|
GHD | Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic gh deficiency | PHV (cm/year) = 14.55 + (–1.37 × maximum GH response (ln; µL)) + (–0.32 × age at onset (years))) + (0.32 × birthweight SD score) + (1.62 × GH dose (ln; IU/kg per week)) + (×0.4 × height SD score – MPH SD score) + (0.29 × bodyweight SD score) (±1.46) (Refer to Table 7.2.6.2). r2 = 0.61 | Ranke et al. (92) |
GHD | A new and accurate prediction model fro growth response to GH treatment in children with GHD | Height velocity at year 1(cm/year) = 3.543 + 0.100 (DPD at 1 month (nmol/mmol Creat)) + 0.299 (height velocity at 3 months (cm/year)) – 0.010 IGF-1 at start (µg/L) – 2.377 (relative bine age retardation as a fraction of bone age) r2 = 0.89 | E. Schönau et al.(93) |
Turner’s syndrome | Prediction of long-term response to GH in Turner’s syndrome: development of mathematical models. | Height velocity (cm/year) = 8.1 + 2.2 (GH dose IU/kg per week) – 0.3 (age at onset (years)) + 0.4 (bodyweight SDS) – 0.2 (height SDS – MPH SDS) + 0.4 (no. injections/week) + 1.6 (oxandrolone = 1, no oxandrolone = 0) r2 = 0.46 | Ranke, et al. (94) |
GHD & ISS | Growth response to GH treatment relates to serum IGF-1 and IGF-BP3 in short children with various Gh secretion capacities | Growth response = 1.1 – 0.0765 (IGF-1 SDS at start) – 0.00415 (age at start) + 0.0924 (weigh SDS at year 1) + 0.150 (delta weight for height SDs pretreatment year) – 0.143 (GH max at AITT) + 0.060 (delta IGF-1 SDS 3 months of treatment) r2 = 0.58 | B. Kristom et al. (95) |
SGA | Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database) | PHV (cm/year) = 8.0 + (–0.31 × age at start (years)) + (0.30 × weight SD score at start) + (56.51 × GH dose (mg/kg per day)) + (0.11 × MPH SD score) ± 1.3. | Ranke, et al. (24) |
GHD Turner’s syndrome ISS | Height velocity targets from the national cooperative growth study for first-year GH response in short children | No equation available Graph of first-year growth velocity (cm/year) with mean ±1 SD (y axis) according to age at start of treatment (x axis) | Bakker et al. (22) |
| Population treated with GH . | Title . | Equation model . | Reference . |
|---|---|---|---|
GHD | Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic gh deficiency | PHV (cm/year) = 14.55 + (–1.37 × maximum GH response (ln; µL)) + (–0.32 × age at onset (years))) + (0.32 × birthweight SD score) + (1.62 × GH dose (ln; IU/kg per week)) + (×0.4 × height SD score – MPH SD score) + (0.29 × bodyweight SD score) (±1.46) (Refer to Table 7.2.6.2). r2 = 0.61 | Ranke et al. (92) |
GHD | A new and accurate prediction model fro growth response to GH treatment in children with GHD | Height velocity at year 1(cm/year) = 3.543 + 0.100 (DPD at 1 month (nmol/mmol Creat)) + 0.299 (height velocity at 3 months (cm/year)) – 0.010 IGF-1 at start (µg/L) – 2.377 (relative bine age retardation as a fraction of bone age) r2 = 0.89 | E. Schönau et al.(93) |
Turner’s syndrome | Prediction of long-term response to GH in Turner’s syndrome: development of mathematical models. | Height velocity (cm/year) = 8.1 + 2.2 (GH dose IU/kg per week) – 0.3 (age at onset (years)) + 0.4 (bodyweight SDS) – 0.2 (height SDS – MPH SDS) + 0.4 (no. injections/week) + 1.6 (oxandrolone = 1, no oxandrolone = 0) r2 = 0.46 | Ranke, et al. (94) |
GHD & ISS | Growth response to GH treatment relates to serum IGF-1 and IGF-BP3 in short children with various Gh secretion capacities | Growth response = 1.1 – 0.0765 (IGF-1 SDS at start) – 0.00415 (age at start) + 0.0924 (weigh SDS at year 1) + 0.150 (delta weight for height SDs pretreatment year) – 0.143 (GH max at AITT) + 0.060 (delta IGF-1 SDS 3 months of treatment) r2 = 0.58 | B. Kristom et al. (95) |
SGA | Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database) | PHV (cm/year) = 8.0 + (–0.31 × age at start (years)) + (0.30 × weight SD score at start) + (56.51 × GH dose (mg/kg per day)) + (0.11 × MPH SD score) ± 1.3. | Ranke, et al. (24) |
GHD Turner’s syndrome ISS | Height velocity targets from the national cooperative growth study for first-year GH response in short children | No equation available Graph of first-year growth velocity (cm/year) with mean ±1 SD (y axis) according to age at start of treatment (x axis) | Bakker et al. (22) |
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