Table 7.2.10.3 Open in new tab Benign...

Table 7.2.10.3

Benign variants of premature sexual maturation

Condition
Non-progressive precocious puberty	See Table 7.2.10.5 for differential characteristics with progressive central precocious puberty
Isolated precocious thelarche	Unilateral or bilateral breast development; particularly frequent before the age of 3 years	No further evaluation needed in most cases
Isolated precocious pubarche	Pubic hair development can be associated with adult body odour, axillary hair or mild acne	Normal cortisol precursors in serum, including normal levels of 17OH-progesterone after ACTH stimulation; normal or moderately elevated DHEAS
Isolated precocious menarche	Isolated vaginal bleeding without breast development or pubic hair, and no genital trauma. It is important to evaluate clinically for a vaginal lesion (sex abuse, foreign body, tumour)

Condition
Non-progressive precocious puberty	See Table 7.2.10.5 for differential characteristics with progressive central precocious puberty
Isolated precocious thelarche	Unilateral or bilateral breast development; particularly frequent before the age of 3 years	No further evaluation needed in most cases
Isolated precocious pubarche	Pubic hair development can be associated with adult body odour, axillary hair or mild acne	Normal cortisol precursors in serum, including normal levels of 17OH-progesterone after ACTH stimulation; normal or moderately elevated DHEAS
Isolated precocious menarche	Isolated vaginal bleeding without breast development or pubic hair, and no genital trauma. It is important to evaluate clinically for a vaginal lesion (sex abuse, foreign body, tumour)