Table 7.2.10.6 Open in new tab...

Table 7.2.10.6

Long-acting GnRH agonists used for the treatment of central precocious puberty

Depot GnRH agonists	Brand name	Usual starting dose^a
Buserelin	Suprefact depot	6.3 mg every 2 months
Goserelin	Zoladex LA	3.6 mg every month OR 10.8 mg every 3 months
Histrelin	Supprelin LA	50 mg implant every year
Leuprolide	Enantone or Lupron-depot	3.75 mg every month OR 11.25 mg every 3 months
	Prostap SR	4–8 µg/kg/day
	Lupron-depot-PED	7.5, 11.25, or 15 mg every month (0.2–0.3 mg/kg per month) OR 11.25 mg every 3 months^a
Triptorelin	Decapeptyl, Gonapeptyl	3 or 3.75 mg every month OR 11.25 mg every 3 months

Depot GnRH agonists	Brand name	Usual starting dose^a
Buserelin	Suprefact depot	6.3 mg every 2 months
Goserelin	Zoladex LA	3.6 mg every month OR 10.8 mg every 3 months
Histrelin	Supprelin LA	50 mg implant every year
Leuprolide	Enantone or Lupron-depot	3.75 mg every month OR 11.25 mg every 3 months
	Prostap SR	4–8 µg/kg/day
	Lupron-depot-PED	7.5, 11.25, or 15 mg every month (0.2–0.3 mg/kg per month) OR 11.25 mg every 3 months^a
Triptorelin	Decapeptyl, Gonapeptyl	3 or 3.75 mg every month OR 11.25 mg every 3 months

The availability and approval for use in precocious puberty of these medications vary throughout the world. Recommended dosages also vary around the world for the same drug.

Reproduced with permission from (2).

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