Estimated Cases of Radiation-Caused Cancer Incidence (Top Table) and Mortality (Bottom Table) per 100 000 Women Exposed to the Doses Shown for Various Existing and Prospective Screening Modalities as a Function of Age at Exposure
| . | . | Risk of Radiation-caused Cancer Incidence . | |||||
|---|---|---|---|---|---|---|---|
| Screening Modality . | Estimated MGD (mGy) . | Age 30 . | Age 40 . | Age 50 . | Age 60 . | Age 70 . | Age 80 . |
| Digital mammography | 3.0 | 7.6 | 4.2 | 2.1 | 0.9 | 0.4 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 7.6–11.4 | 4.2–6.3 | 2.1–3.2 | 0.9–1.4 | 0.4–0.5 | 0.1–0.2 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 7.6–9.5 | 4.2–5.3 | 2.1–2.6 | 0.9–1.2 | 0.4–0.5 | 0.1–0.2 |
| DBT+DM (each in 2 views) | 6.0–7.5 | 15–19 | 8.5–11 | 4.2–5.3 | 1.9–2.3 | 0.7–0.9 | 0.2–0.3 |
| Whole-breast CT | 6.0–11.0 | 15–28 | 8.5–16 | 4.2–7.7 | 1.9–3.4 | 0.7–1.3 | 0.2–0.4 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 89 | 82 | 73 | 60 | 42 | 21 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 19 | 18 | 16 | 13 | 9 | 5 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 81 | 75 | 68 | 57 | 40 | 20 |
| Risk of Radiation-caused Cancer Death | |||||||
| Digital mammography | 3.0 | 1.8 | 1.1 | 0.6 | 0.3 | 0.2 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 1.8–2.3 | 1.1–1.6 | 0.6–0.9 | 0.3–0.4 | 0.2 | 0.1 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 1.8–2.3 | 1.1–1.3 | 0.6–0.7 | 0.3 | 0.2 | 0.1 |
| DBT+DM (each In 2 views) | 6.0–7.5 | 3.7–4.6 | 2.1–2.6 | 1.1–1.4 | 0.5–0.7 | 0.3–0.4 | 0.1–0.2 |
| Whole-breast CT | 6.0–11.0 | 3.7–6.7 | 2.1–3.9 | 1.1–2.1 | 0.5–1.0 | 0.3–0.6 | 0.1–0.2 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 40 | 39 | 36 | 32 | 25 | 15 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 9 | 9 | 8 | 7 | 5 | 3 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 32 | 31 | 28 | 26 | 21 | 13 |
| . | . | Risk of Radiation-caused Cancer Incidence . | |||||
|---|---|---|---|---|---|---|---|
| Screening Modality . | Estimated MGD (mGy) . | Age 30 . | Age 40 . | Age 50 . | Age 60 . | Age 70 . | Age 80 . |
| Digital mammography | 3.0 | 7.6 | 4.2 | 2.1 | 0.9 | 0.4 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 7.6–11.4 | 4.2–6.3 | 2.1–3.2 | 0.9–1.4 | 0.4–0.5 | 0.1–0.2 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 7.6–9.5 | 4.2–5.3 | 2.1–2.6 | 0.9–1.2 | 0.4–0.5 | 0.1–0.2 |
| DBT+DM (each in 2 views) | 6.0–7.5 | 15–19 | 8.5–11 | 4.2–5.3 | 1.9–2.3 | 0.7–0.9 | 0.2–0.3 |
| Whole-breast CT | 6.0–11.0 | 15–28 | 8.5–16 | 4.2–7.7 | 1.9–3.4 | 0.7–1.3 | 0.2–0.4 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 89 | 82 | 73 | 60 | 42 | 21 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 19 | 18 | 16 | 13 | 9 | 5 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 81 | 75 | 68 | 57 | 40 | 20 |
| Risk of Radiation-caused Cancer Death | |||||||
| Digital mammography | 3.0 | 1.8 | 1.1 | 0.6 | 0.3 | 0.2 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 1.8–2.3 | 1.1–1.6 | 0.6–0.9 | 0.3–0.4 | 0.2 | 0.1 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 1.8–2.3 | 1.1–1.3 | 0.6–0.7 | 0.3 | 0.2 | 0.1 |
| DBT+DM (each In 2 views) | 6.0–7.5 | 3.7–4.6 | 2.1–2.6 | 1.1–1.4 | 0.5–0.7 | 0.3–0.4 | 0.1–0.2 |
| Whole-breast CT | 6.0–11.0 | 3.7–6.7 | 2.1–3.9 | 1.1–2.1 | 0.5–1.0 | 0.3–0.6 | 0.1–0.2 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 40 | 39 | 36 | 32 | 25 | 15 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 9 | 9 | 8 | 7 | 5 | 3 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 32 | 31 | 28 | 26 | 21 | 13 |
Adapted from reference (3) based on BEIR-VII (35).
Abbreviations: BSGI, breast-specific gamma imaging; CT, computed tomography; DBT, digital breast tomosynthesis; DM, digital mammography; MBI, molecular breast imaging; MBq, megabequerel; mCi, millicurie; MGD, mean glandular dose; mGy, milligray; PEM, positron emission mammography.
aAssumes 300 MBq (8 mCi) drawn or administered, 240 MBq (6.4 mCi) received (28, 29).
Estimated Cases of Radiation-Caused Cancer Incidence (Top Table) and Mortality (Bottom Table) per 100 000 Women Exposed to the Doses Shown for Various Existing and Prospective Screening Modalities as a Function of Age at Exposure
| . | . | Risk of Radiation-caused Cancer Incidence . | |||||
|---|---|---|---|---|---|---|---|
| Screening Modality . | Estimated MGD (mGy) . | Age 30 . | Age 40 . | Age 50 . | Age 60 . | Age 70 . | Age 80 . |
| Digital mammography | 3.0 | 7.6 | 4.2 | 2.1 | 0.9 | 0.4 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 7.6–11.4 | 4.2–6.3 | 2.1–3.2 | 0.9–1.4 | 0.4–0.5 | 0.1–0.2 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 7.6–9.5 | 4.2–5.3 | 2.1–2.6 | 0.9–1.2 | 0.4–0.5 | 0.1–0.2 |
| DBT+DM (each in 2 views) | 6.0–7.5 | 15–19 | 8.5–11 | 4.2–5.3 | 1.9–2.3 | 0.7–0.9 | 0.2–0.3 |
| Whole-breast CT | 6.0–11.0 | 15–28 | 8.5–16 | 4.2–7.7 | 1.9–3.4 | 0.7–1.3 | 0.2–0.4 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 89 | 82 | 73 | 60 | 42 | 21 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 19 | 18 | 16 | 13 | 9 | 5 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 81 | 75 | 68 | 57 | 40 | 20 |
| Risk of Radiation-caused Cancer Death | |||||||
| Digital mammography | 3.0 | 1.8 | 1.1 | 0.6 | 0.3 | 0.2 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 1.8–2.3 | 1.1–1.6 | 0.6–0.9 | 0.3–0.4 | 0.2 | 0.1 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 1.8–2.3 | 1.1–1.3 | 0.6–0.7 | 0.3 | 0.2 | 0.1 |
| DBT+DM (each In 2 views) | 6.0–7.5 | 3.7–4.6 | 2.1–2.6 | 1.1–1.4 | 0.5–0.7 | 0.3–0.4 | 0.1–0.2 |
| Whole-breast CT | 6.0–11.0 | 3.7–6.7 | 2.1–3.9 | 1.1–2.1 | 0.5–1.0 | 0.3–0.6 | 0.1–0.2 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 40 | 39 | 36 | 32 | 25 | 15 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 9 | 9 | 8 | 7 | 5 | 3 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 32 | 31 | 28 | 26 | 21 | 13 |
| . | . | Risk of Radiation-caused Cancer Incidence . | |||||
|---|---|---|---|---|---|---|---|
| Screening Modality . | Estimated MGD (mGy) . | Age 30 . | Age 40 . | Age 50 . | Age 60 . | Age 70 . | Age 80 . |
| Digital mammography | 3.0 | 7.6 | 4.2 | 2.1 | 0.9 | 0.4 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 7.6–11.4 | 4.2–6.3 | 2.1–3.2 | 0.9–1.4 | 0.4–0.5 | 0.1–0.2 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 7.6–9.5 | 4.2–5.3 | 2.1–2.6 | 0.9–1.2 | 0.4–0.5 | 0.1–0.2 |
| DBT+DM (each in 2 views) | 6.0–7.5 | 15–19 | 8.5–11 | 4.2–5.3 | 1.9–2.3 | 0.7–0.9 | 0.2–0.3 |
| Whole-breast CT | 6.0–11.0 | 15–28 | 8.5–16 | 4.2–7.7 | 1.9–3.4 | 0.7–1.3 | 0.2–0.4 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 89 | 82 | 73 | 60 | 42 | 21 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 19 | 18 | 16 | 13 | 9 | 5 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 81 | 75 | 68 | 57 | 40 | 20 |
| Risk of Radiation-caused Cancer Death | |||||||
| Digital mammography | 3.0 | 1.8 | 1.1 | 0.6 | 0.3 | 0.2 | 0.1 |
| DBT only (2 views) | 3.0–4.5 | 1.8–2.3 | 1.1–1.6 | 0.6–0.9 | 0.3–0.4 | 0.2 | 0.1 |
| DBT (1 view) + DM (other view) | 3.0–3.75 | 1.8–2.3 | 1.1–1.3 | 0.6–0.7 | 0.3 | 0.2 | 0.1 |
| DBT+DM (each In 2 views) | 6.0–7.5 | 3.7–4.6 | 2.1–2.6 | 1.1–1.4 | 0.5–0.7 | 0.3–0.4 | 0.1–0.2 |
| Whole-breast CT | 6.0–11.0 | 3.7–6.7 | 2.1–3.9 | 1.1–2.1 | 0.5–1.0 | 0.3–0.6 | 0.1–0.2 |
| Administered Dose | |||||||
| BSGI (99mTc-sestamibi) | 1110 MBq (30 mCi) | 40 | 39 | 36 | 32 | 25 | 15 |
| MBI (99mTc-sestamibi) | 300 MBq (8 mCi)a | 9 | 9 | 8 | 7 | 5 | 3 |
| PEM (F-18 FDG) | 370 MBq (10 mCi) | 32 | 31 | 28 | 26 | 21 | 13 |
Adapted from reference (3) based on BEIR-VII (35).
Abbreviations: BSGI, breast-specific gamma imaging; CT, computed tomography; DBT, digital breast tomosynthesis; DM, digital mammography; MBI, molecular breast imaging; MBq, megabequerel; mCi, millicurie; MGD, mean glandular dose; mGy, milligray; PEM, positron emission mammography.
aAssumes 300 MBq (8 mCi) drawn or administered, 240 MBq (6.4 mCi) received (28, 29).
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