Table 1.

List of Medications with Anticholinergic Properties Used by Study Participants in the 60+ Cohort of the PATH Through Life Study Between Wave 2 and Wave 3 (Minimum Effective Dose)(21)

Antihistamines

  • Cyproheptadine (4 mg)

  • Cetirizine (5 mg)

  • Loratadine (10 mg) Antidepressants

  • Amitriptyline (10 mg)

  • Clomipramine (25 mg)

  • Doxepin (10 mg)

  • Imipramine (10 mg)

  • Nortriptyline (10 mg)

  • Paroxetine (10 mg)

  • Mirtazepine (7.5mg) Antivertigo/antiemetic

  • Prochlorperazine (15 mg)

  • Promethazine (50 mg)

  • Metoclopramide (10 mg) Antacids and antihistamines

  • Ranitidine (150 mg)

Antiparkinson agents

  • Benztropine (0.5 mg)

  • Trihexyphenidyl (6 mg)

  • Amantadine (100 mg)

  • Levodopa (100 mg)

  • Carbidopa (25 mg)

  • Pramipexole (0.125 mg)

  • Entacapone (200 mg) Antipsychotics

  • Chlorpromazine (10 mg)

  • Olanzapine (2.5 mg)

  • Quetiapine (50 mg)

  • Haloperidol (0.25 mg)

  • Risperidone (0.25 mg) Bladder antimuscarinics

  • Oxybutynin ºPatch (3.9 mg) ºOral (5 mg)

Gastrointestinal antispasmodics

  • Propantheline (22.5 mg)

  • Loperamide (4 mg)

Skeletal muscle relaxants

  • Baclofen (5 mg) Anticonvulsant

  • Carbamazepine (400 mg)

Antihistamines

  • Cyproheptadine (4 mg)

  • Cetirizine (5 mg)

  • Loratadine (10 mg) Antidepressants

  • Amitriptyline (10 mg)

  • Clomipramine (25 mg)

  • Doxepin (10 mg)

  • Imipramine (10 mg)

  • Nortriptyline (10 mg)

  • Paroxetine (10 mg)

  • Mirtazepine (7.5mg) Antivertigo/antiemetic

  • Prochlorperazine (15 mg)

  • Promethazine (50 mg)

  • Metoclopramide (10 mg) Antacids and antihistamines

  • Ranitidine (150 mg)

Antiparkinson agents

  • Benztropine (0.5 mg)

  • Trihexyphenidyl (6 mg)

  • Amantadine (100 mg)

  • Levodopa (100 mg)

  • Carbidopa (25 mg)

  • Pramipexole (0.125 mg)

  • Entacapone (200 mg) Antipsychotics

  • Chlorpromazine (10 mg)

  • Olanzapine (2.5 mg)

  • Quetiapine (50 mg)

  • Haloperidol (0.25 mg)

  • Risperidone (0.25 mg) Bladder antimuscarinics

  • Oxybutynin ºPatch (3.9 mg) ºOral (5 mg)

Gastrointestinal antispasmodics

  • Propantheline (22.5 mg)

  • Loperamide (4 mg)

Skeletal muscle relaxants

  • Baclofen (5 mg) Anticonvulsant

  • Carbamazepine (400 mg)

Table 1.

List of Medications with Anticholinergic Properties Used by Study Participants in the 60+ Cohort of the PATH Through Life Study Between Wave 2 and Wave 3 (Minimum Effective Dose)(21)

Antihistamines

  • Cyproheptadine (4 mg)

  • Cetirizine (5 mg)

  • Loratadine (10 mg) Antidepressants

  • Amitriptyline (10 mg)

  • Clomipramine (25 mg)

  • Doxepin (10 mg)

  • Imipramine (10 mg)

  • Nortriptyline (10 mg)

  • Paroxetine (10 mg)

  • Mirtazepine (7.5mg) Antivertigo/antiemetic

  • Prochlorperazine (15 mg)

  • Promethazine (50 mg)

  • Metoclopramide (10 mg) Antacids and antihistamines

  • Ranitidine (150 mg)

Antiparkinson agents

  • Benztropine (0.5 mg)

  • Trihexyphenidyl (6 mg)

  • Amantadine (100 mg)

  • Levodopa (100 mg)

  • Carbidopa (25 mg)

  • Pramipexole (0.125 mg)

  • Entacapone (200 mg) Antipsychotics

  • Chlorpromazine (10 mg)

  • Olanzapine (2.5 mg)

  • Quetiapine (50 mg)

  • Haloperidol (0.25 mg)

  • Risperidone (0.25 mg) Bladder antimuscarinics

  • Oxybutynin ºPatch (3.9 mg) ºOral (5 mg)

Gastrointestinal antispasmodics

  • Propantheline (22.5 mg)

  • Loperamide (4 mg)

Skeletal muscle relaxants

  • Baclofen (5 mg) Anticonvulsant

  • Carbamazepine (400 mg)

Antihistamines

  • Cyproheptadine (4 mg)

  • Cetirizine (5 mg)

  • Loratadine (10 mg) Antidepressants

  • Amitriptyline (10 mg)

  • Clomipramine (25 mg)

  • Doxepin (10 mg)

  • Imipramine (10 mg)

  • Nortriptyline (10 mg)

  • Paroxetine (10 mg)

  • Mirtazepine (7.5mg) Antivertigo/antiemetic

  • Prochlorperazine (15 mg)

  • Promethazine (50 mg)

  • Metoclopramide (10 mg) Antacids and antihistamines

  • Ranitidine (150 mg)

Antiparkinson agents

  • Benztropine (0.5 mg)

  • Trihexyphenidyl (6 mg)

  • Amantadine (100 mg)

  • Levodopa (100 mg)

  • Carbidopa (25 mg)

  • Pramipexole (0.125 mg)

  • Entacapone (200 mg) Antipsychotics

  • Chlorpromazine (10 mg)

  • Olanzapine (2.5 mg)

  • Quetiapine (50 mg)

  • Haloperidol (0.25 mg)

  • Risperidone (0.25 mg) Bladder antimuscarinics

  • Oxybutynin ºPatch (3.9 mg) ºOral (5 mg)

Gastrointestinal antispasmodics

  • Propantheline (22.5 mg)

  • Loperamide (4 mg)

Skeletal muscle relaxants

  • Baclofen (5 mg) Anticonvulsant

  • Carbamazepine (400 mg)

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