Table 46.2
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Summary of outcomes of in vitro cultivation of Cryptosporidium species (primarily C. parvum) from various hosts in selected cell lines
Cell line (ATCC no.) Oocyst source Life-cycle stages Infective oocysts Key refs

HRT

Cattle

Asexual

Not detected

(Woodmansee and Pohlenz 1983)

CAM

Human, Cattle, Birds

All

Yes

(Current and Long 1983)

HFL

Human (goats)

All

Yes

(Current and Haynes 1984)

PCK

Human (goats)

All

Yes

(Current and Haynes 1984)

PK-10

Human (goats)

All

Yes

(Current and Haynes 1984)

BHK (CRL-1632)

Human (goats)

Asexual

Not reported

(Naciri et al. 1986)

HT29.74 (HTB-38)

Human

Asexual

Not reported

(Flanigan et al. 1991)

MDBK (CCL-22)

Cattle

All1

Yes

(Upton et al. 1994c)

MDCK (CCL-34)

Sheep, Cattle

All

Yes

(Gut et al. 1991)

RL95-2 (CRL-1671)

Cattle

All2

Not reported

(Rasmussen et al. 1993)

Caco-2 (HTB-37)

Human, Cattle

All3

Yes

(Griffiths et al. 1994)

HCT-8 (CCL-224)

Cattle

All

Yes

(Hijjawi et al. 2001a)

VELI

Sheep (lamb)

All

Yes

(Lacharme et al. 2004)

Cell line (ATCC no.) Oocyst source Life-cycle stages Infective oocysts Key refs

HRT

Cattle

Asexual

Not detected

(Woodmansee and Pohlenz 1983)

CAM

Human, Cattle, Birds

All

Yes

(Current and Long 1983)

HFL

Human (goats)

All

Yes

(Current and Haynes 1984)

PCK

Human (goats)

All

Yes

(Current and Haynes 1984)

PK-10

Human (goats)

All

Yes

(Current and Haynes 1984)

BHK (CRL-1632)

Human (goats)

Asexual

Not reported

(Naciri et al. 1986)

HT29.74 (HTB-38)

Human

Asexual

Not reported

(Flanigan et al. 1991)

MDBK (CCL-22)

Cattle

All1

Yes

(Upton et al. 1994c)

MDCK (CCL-34)

Sheep, Cattle

All

Yes

(Gut et al. 1991)

RL95-2 (CRL-1671)

Cattle

All2

Not reported

(Rasmussen et al. 1993)

Caco-2 (HTB-37)

Human, Cattle

All3

Yes

(Griffiths et al. 1994)

HCT-8 (CCL-224)

Cattle

All

Yes

(Hijjawi et al. 2001a)

VELI

Sheep (lamb)

All

Yes

(Lacharme et al. 2004)

Abbreviations: ATCC (The American Type Culture Collection); HRT (human rectal tumour cells); CAM (chorioallantoic membrane); HFL (human foetal lung cells); PCK (primary chicken kidney cells); PK-10 (porcine kidney cells); BHK (baby hamster kidney cells); MDBK (Madin-Darby bovine kidney cells); MDCK (Madin-Darby canine kidney cells); RL95-2 (human endometrial carcinoma cells); HCT-8 (human colonic tumor cells); VELI (rabbit chondrocyte cell line).

Adapted from Arrowood et al. (2002).

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