Table 46.4
Key pathological changes reported to be associated with various common manifestations of human cryptosporidiosis
InfectionSalient pathological changes describedKey refs

Pulmonary

Inflammation and fibrosis of the bronchial epithelia;

 

Loss of epithelial cilia;

 

Thickening of the lung parenchyma;

 

Presence of thick mucus and lesions in the bronchial sacs.

(Tarwid et al. 1985; Blagburn et al. 1987)

Gastric

Non-specific lesions and oedema;

 

Hyperplasia of the epithelial cells;

 

Inflammation of the lamina propria.

(Rivasi et al. 1999; Taylor et al. 1999; Masuno et al. 2006)

Intestinal

Loss of mature enterocytes;

 

Villius atrophy;

 

Lengthening of crypts (hyperplasia);

 

Oedema;

 

Loss of membrane-bound digestive enzymes;

 

Diminished absorptive surface of the intestine.

(Inman and Takeuchi, 1979; Tzipori et al. 1981; Pearson and Logan 1983)

Pancreatic

Dilation of the pancreatic duct;

 

Formation of hyperplasic lesions;

 

Thickening of the epithelium.

(Cappell and Hassan 1993)

InfectionSalient pathological changes describedKey refs

Pulmonary

Inflammation and fibrosis of the bronchial epithelia;

 

Loss of epithelial cilia;

 

Thickening of the lung parenchyma;

 

Presence of thick mucus and lesions in the bronchial sacs.

(Tarwid et al. 1985; Blagburn et al. 1987)

Gastric

Non-specific lesions and oedema;

 

Hyperplasia of the epithelial cells;

 

Inflammation of the lamina propria.

(Rivasi et al. 1999; Taylor et al. 1999; Masuno et al. 2006)

Intestinal

Loss of mature enterocytes;

 

Villius atrophy;

 

Lengthening of crypts (hyperplasia);

 

Oedema;

 

Loss of membrane-bound digestive enzymes;

 

Diminished absorptive surface of the intestine.

(Inman and Takeuchi, 1979; Tzipori et al. 1981; Pearson and Logan 1983)

Pancreatic

Dilation of the pancreatic duct;

 

Formation of hyperplasic lesions;

 

Thickening of the epithelium.

(Cappell and Hassan 1993)

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