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	0	1	2	3	4
Respiratory PaO₂:FIO₂ ratio (mmHg)	>400	>400	≤300	≤200^*	<100^*
Renal Creatinine (mg/dL) or urine output (mL/d)	<1.2	1.2–1.9	2.0–3.4	3.5–4.9 or <500mL/d	≤5.0 or<200mL/d
Hepatic Bilirubin (mg/dL)	<1.2	1.2–1.9	2.0–5.9	6.0–11.9	12.0
Cardiovascular Mean arterial pressure (mmHg)	No hypotension	MAP >70	Dopamine≤5 or dobutamine (any dose)^†	Dopamine >5 or epinephrine ≤0.1 epinephrine ≤0.1^†	Dopamine >15 or epinephrine >0.1epinephrine >0.1^†
Haematological Platelet count (x10³/mm³)	>150	≤150	≤100	≤50	≤20
Neurological Glasgow coma score	15	13–14	10–12	6–9	<6

	0	1	2	3	4
Respiratory PaO₂:FIO₂ ratio (mmHg)	>400	>400	≤300	≤200^*	<100^*
Renal Creatinine (mg/dL) or urine output (mL/d)	<1.2	1.2–1.9	2.0–3.4	3.5–4.9 or <500mL/d	≤5.0 or<200mL/d
Hepatic Bilirubin (mg/dL)	<1.2	1.2–1.9	2.0–5.9	6.0–11.9	12.0
Cardiovascular Mean arterial pressure (mmHg)	No hypotension	MAP >70	Dopamine≤5 or dobutamine (any dose)^†	Dopamine >5 or epinephrine ≤0.1 epinephrine ≤0.1^†	Dopamine >15 or epinephrine >0.1epinephrine >0.1^†
Haematological Platelet count (x10³/mm³)	>150	≤150	≤100	≤50	≤20
Neurological Glasgow coma score	15	13–14	10–12	6–9	<6

With ventilatory support;

Adrenergic agents administered for at least 1h (doses in mcg/kg/min).