Table 3.3
Causes of hyper-eosinophilia

Infections

Parasitic infections

HIV

Allergic diseases

Eczema

Drug reactions—DRESS syndrome

Immunological disease

Hyper-IgE syndrome

Graft-versus-host syndrome

Transplant rejection

Malignant disease

Myeloid leukaemia

Lymphoma (especially Hodgkin’s)—associated with PDGFRB or FGFR1 gene rearrangements

Mastocytosis

Pulmonary disease

Loeffler’s syndrome

ABPA

Eosinophilic pneumonia

Gastrointestinal disease

Eosinophilic oesophagitis/enteritis

Skin disease

Bullous diseases

Eosinophilic cellulitis (Wells syndrome)

Kimura’s disease

Eosinophilic fasciitis (Shulman’s disease)

Episodic angioedema with eosinophilia (fever and weight gain)

Vasculitis

Churg–Strauss syndrome

Cholesterol emboli

Miscellaneous

Addison’s disease

Idiopathic

Infections

Parasitic infections

HIV

Allergic diseases

Eczema

Drug reactions—DRESS syndrome

Immunological disease

Hyper-IgE syndrome

Graft-versus-host syndrome

Transplant rejection

Malignant disease

Myeloid leukaemia

Lymphoma (especially Hodgkin’s)—associated with PDGFRB or FGFR1 gene rearrangements

Mastocytosis

Pulmonary disease

Loeffler’s syndrome

ABPA

Eosinophilic pneumonia

Gastrointestinal disease

Eosinophilic oesophagitis/enteritis

Skin disease

Bullous diseases

Eosinophilic cellulitis (Wells syndrome)

Kimura’s disease

Eosinophilic fasciitis (Shulman’s disease)

Episodic angioedema with eosinophilia (fever and weight gain)

Vasculitis

Churg–Strauss syndrome

Cholesterol emboli

Miscellaneous

Addison’s disease

Idiopathic

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