Arthritis (non-deforming)

Serositis (pericarditis, pleurisy, peritonitis)

Rashes; photosensitivity; malar (butterfly) rash

Anti-Ro; anti-La

Urticaria

Angioedema

Anti-C1 esterase inhibitor; anti-C1q

Alopecia (scarring); vitiligo

Anti-melanocyte

Mouth ulcers

Sicca syndrome

Anti-Ro; anti-La

Glomerulonephritis; nephrotic syndrome

Anti-dsDNA; anti-C1q

Neurological disorder (psychosis, seizures)

Anti-ribosomal P; anti-neuronal

Peripheral neuropathy; mononeuritis

Transverse myelitis; optic neuritis (MS-like)

ANA

Myasthenia gravis

Anti-acetylcholine receptor (AchRAb)

Haemolytic anaemia

Anti-erythrocyte; Coombs’ test +ve

Thrombocytopenia

Anti-platelet; anti-phospholipid

Lymphopenia

Lymphocytotoxic antibodies (anti-MHC)

Neutropenia

Anti-neutrophil antibodies

Venous thrombosis; pulmonary emboli

Anti-phospholipid antibodies

Recurrent miscarriage; livedo reticularis

Anti-phospholipid antibodies

Endocarditis

Anti-phospholipid antibodies

Raynaud’s phenomenon

Anti-phospholipid antibodies; cryoglobulins (type II or III)

Shrinking lung

Hepatitis

Anti-smooth muscle; anti-dsDNA

Mesenteric vasculitis

Organ-specific autoimmune disease

Organ-specific autoantibodies (thyroid peroxidase etc.)

Neonatal lupus; congenital complete heart block

Anti-Ro; anti-La

Drug-induced lupus

Anti-histone; anti-ssDNA