Box 12.5
Testing for MCTD
Tests for diagnosisTests for monitoring

FBC

FBC

Cr&E

Cr&E

LFTs, CK

LFTs, CK

TFTs

TFTs

Urine (RBCs, casts, protein, creatinine clearance)

Urine (RBCs, casts, protein, creatinine clearance)

ANA

Immunoglobulins, electrophoresis

dsDNA

C3, C4

ENA (U1-RNP)

Diffusing capacity and lung function

HEp-2 screen

Echocardiogram annually (for PA pressure and development of pulmonary hypertension)

RhF

Anti-phospholipid antibodies

Immunoglobulins, electrophoresis

C3, C4

Cryoglobulins

ESR, CRP

Diffusing capacity and lung function Echocardiogram (baseline PA pressure)

Tests for diagnosisTests for monitoring

FBC

FBC

Cr&E

Cr&E

LFTs, CK

LFTs, CK

TFTs

TFTs

Urine (RBCs, casts, protein, creatinine clearance)

Urine (RBCs, casts, protein, creatinine clearance)

ANA

Immunoglobulins, electrophoresis

dsDNA

C3, C4

ENA (U1-RNP)

Diffusing capacity and lung function

HEp-2 screen

Echocardiogram annually (for PA pressure and development of pulmonary hypertension)

RhF

Anti-phospholipid antibodies

Immunoglobulins, electrophoresis

C3, C4

Cryoglobulins

ESR, CRP

Diffusing capacity and lung function Echocardiogram (baseline PA pressure)

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