M1

Cardiolipin

Distal tubules ++

Syphilis anti-phospholipid syndrome (1° and 2°)

M2

Pyruvate (2-oxo-acid) dehydrogenase complex

Distal tubules ++

Parietal cells ++

Primary biliary cirrhosis (PBC) Also seen in RhA, SSc

M3

Not known

Proximal P1, P2, P3 ++

Distal tubules ++

Parietal cells ++

Lupus-like disease

M4

Sulphite oxidase

Proximal tubules +

PBC (often with M2)

Distal tubules ++

Parietal cells ++

PBC–scleroderma overlap

M5

Not known

P1, P2 proximal tubules ++

P3 proximal tubules +

Parietal cells +

Miscellaneous connective tissue diseases

Occur with anti-β2-GPI antibodies in APS

M6

Monamine oxidase B

P1 proximal tubules++

Loop of Henle ++

APUD cells, stomach ++

Iproniazid-induced hepatitis

M7

Sarcosine dehydrogenase

Distal tubules ++

P2, P3 proximal tubules +

Myocarditis cardiomyopathy

M8

Not known

Distal tubules ++

Collecting ducts ++

PBC (often with M2)

M9

Glycogen phosphorylase

Distal tubules ++

Collecting ducts ++

PBC (mild disease?) Autoimmune hepatitis