Table 25.2
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Summary of novel biomarkers in acute and chronic heart failure
BiomarkerPlasma levels in ADHFIndependent prognostic information?Levels altered with therapy?Plasma levels in CHFIndependent prognostic information?Levels altered with therapy?

MR-proANP

↑

Yes

U

↑

Yes

U

MR-proADM

U

U

U

↑

Yes

U

copeptin

↑

Yes

U

↑

Yes

U

Apelin

↔

No

No

↓

U

Yes

Urocortin

U

U

U

↑

U

U

CgA

↑

Yes

U

↑

Yes

No

CoQ10

U

U

U

↓

Yes

U

Adiponectin

↑

Yes

U

↑

Yes

U

H-FABP

U

U

U

↑

Yes

Yes

MLC-1

U

U

U

↑

Yes

U

Osteopontin

U

U

U

↑

Yes

U

GDF-15

U

U

U

↑

Yes

U

Pentraxin-3

U

U

U

↑

Yes

U

Secretory sphingomyelinase

U

U

U

↑

Yes

U

CT-1

U

U

U

↑

Yes

U

Gal-3

↑

Yes

U

↑

U

No

ST2

↑

Yes

U

↑

Yes

U

Cystatin C

↑

Yes

U

↑

Yes

U

SP-B

↑

U

Yes

↑

U

Yes

BiomarkerPlasma levels in ADHFIndependent prognostic information?Levels altered with therapy?Plasma levels in CHFIndependent prognostic information?Levels altered with therapy?

MR-proANP

↑

Yes

U

↑

Yes

U

MR-proADM

U

U

U

↑

Yes

U

copeptin

↑

Yes

U

↑

Yes

U

Apelin

↔

No

No

↓

U

Yes

Urocortin

U

U

U

↑

U

U

CgA

↑

Yes

U

↑

Yes

No

CoQ10

U

U

U

↓

Yes

U

Adiponectin

↑

Yes

U

↑

Yes

U

H-FABP

U

U

U

↑

Yes

Yes

MLC-1

U

U

U

↑

Yes

U

Osteopontin

U

U

U

↑

Yes

U

GDF-15

U

U

U

↑

Yes

U

Pentraxin-3

U

U

U

↑

Yes

U

Secretory sphingomyelinase

U

U

U

↑

Yes

U

CT-1

U

U

U

↑

Yes

U

Gal-3

↑

Yes

U

↑

U

No

ST2

↑

Yes

U

↑

Yes

U

Cystatin C

↑

Yes

U

↑

Yes

U

SP-B

↑

U

Yes

↑

U

Yes

↑: raised; ↓: reduced; ↔: no change; ADHF; acutely decompensated heart failure; CHF, congestive heart failure; U, unknown.

Adapted from Dalzel JR et al. Biomark Med 2009;3(5):483–93.

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