Short-acting

Regular/soluble

30–60min

1.5–3hr

4–6hr

Rapid (analogue)

Insulin lispro

Insulin aspart

5–30min

15–30min

30–90min

1–3hr

3–5hr

3–5hr

Intermediate acti g

NPH

Lente

1–4hr

3–4hr

–10hr

6–12hr

10–16hr

12–18hr

Long-acting

Ultralente

1–4hr

8–16hr

18–22hr

Long-acting (analogue)

Insulin detemir

Insulin glargine

2–4hr

–2hr

None

None

12–20hr

20–24hr