| Infection . | Bacteria . | Initial empirical drug . | Duration . |
|---|---|---|---|
Acute, uncomplicated cystitis | E. coli, Klebsiella, Proteus, Staphylococci | Nitrofurantoin | 5–7 days |
Alternatives: | |||
Trimethoprim | 5 days | ||
Co-trimoxazole | 3 days | ||
Fluoroquinolone (ciprofloxacin) | 3 days | ||
Acute, uncomplicated pyelonephritis | E. coli, Proteus, Klebsiella, other Enterobacteriacae, Staphylococci | Fluoroquinolone | 7–10 days |
Cephalosporin | |||
Alternatives: | |||
Aminopenicillin with beta-lactamase inhibitor (BLI) (amoxicillin/clavulanic acid) | |||
Aminoglycoside (gentamicin) | |||
Complicated UTI | E. coli, Enterococcus, Pseudomonas, Staphylococci | Fluoroquinolone | Continue for 3–5 days after control of infection/ elimination of underlying cause. Parenteral treatment is usually followed by oral antibiotics to complete course |
Aminopenicillin/BLI | |||
Cephalosporin | |||
Nosocomial* UTI | Staphylococcus, Klebsiella, Proteus | Carbapenem (meropenem) | |
+Aminoglycoside | |||
Acute complicated pyelonephritis | Enterobacter, Pseudomonas, (Candida) | For Candida: | |
–Fluconazole | |||
–Amphotericin B |
| Infection . | Bacteria . | Initial empirical drug . | Duration . |
|---|---|---|---|
Acute, uncomplicated cystitis | E. coli, Klebsiella, Proteus, Staphylococci | Nitrofurantoin | 5–7 days |
Alternatives: | |||
Trimethoprim | 5 days | ||
Co-trimoxazole | 3 days | ||
Fluoroquinolone (ciprofloxacin) | 3 days | ||
Acute, uncomplicated pyelonephritis | E. coli, Proteus, Klebsiella, other Enterobacteriacae, Staphylococci | Fluoroquinolone | 7–10 days |
Cephalosporin | |||
Alternatives: | |||
Aminopenicillin with beta-lactamase inhibitor (BLI) (amoxicillin/clavulanic acid) | |||
Aminoglycoside (gentamicin) | |||
Complicated UTI | E. coli, Enterococcus, Pseudomonas, Staphylococci | Fluoroquinolone | Continue for 3–5 days after control of infection/ elimination of underlying cause. Parenteral treatment is usually followed by oral antibiotics to complete course |
Aminopenicillin/BLI | |||
Cephalosporin | |||
Nosocomial* UTI | Staphylococcus, Klebsiella, Proteus | Carbapenem (meropenem) | |
+Aminoglycoside | |||
Acute complicated pyelonephritis | Enterobacter, Pseudomonas, (Candida) | For Candida: | |
–Fluconazole | |||
–Amphotericin B |
Nosocomial = hospital acquired.
These are general recommendations only, adapted from EAU guidelines, to fit with common UK antibi-otic use. You should be guided by your local microbiology department whose recommendations will be based on local and regional bacterial sensitivities and resistance.
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