| Symptoms and signs . | Associated conditions . | . |
|---|---|---|
Chronic/intermittent diarrhoea (50%) Failure to thrive/faltering growth in children Recurrent abdominal pain/cramping/bloating Other persistent unexplained GI symptoms, e.g. nausea/vomiting Sudden or unexpected weight ↓ Unexplained anaemia (iron deficiency or other) Genetic predisposition First-degree relative (parent, sibling, child) Down’s/Turner syndrome | GI Dental enamel defects Mouth ulcers Irritable bowel syndrome Microscopic colitis Persistent/unexplained constipation Unexplained, persistent ↑ in liver enzymes (usually normalize in <6mo on gluten-free diet) Autoimmune liver disease Musculoskeletal ↓ bone mineral density Low trauma fracture Metabolic bone disease (e.g. rickets, osteomalacia) Sjögren’s syndrome Sarcoidosis | Endocrine Type 1 DM Autoimmune thyroid disease Addison’s disease Amenorrhoea Other Unexplained alopecia Dermatitis herpetiformis Depression or bipolar disorder Polyneuropathy Epilepsy Autoimmune myocarditis Chronic TTP Lymphoma Recurrent miscarriage Unexplained subfertility |
| Symptoms and signs . | Associated conditions . | . |
|---|---|---|
Chronic/intermittent diarrhoea (50%) Failure to thrive/faltering growth in children Recurrent abdominal pain/cramping/bloating Other persistent unexplained GI symptoms, e.g. nausea/vomiting Sudden or unexpected weight ↓ Unexplained anaemia (iron deficiency or other) Genetic predisposition First-degree relative (parent, sibling, child) Down’s/Turner syndrome | GI Dental enamel defects Mouth ulcers Irritable bowel syndrome Microscopic colitis Persistent/unexplained constipation Unexplained, persistent ↑ in liver enzymes (usually normalize in <6mo on gluten-free diet) Autoimmune liver disease Musculoskeletal ↓ bone mineral density Low trauma fracture Metabolic bone disease (e.g. rickets, osteomalacia) Sjögren’s syndrome Sarcoidosis | Endocrine Type 1 DM Autoimmune thyroid disease Addison’s disease Amenorrhoea Other Unexplained alopecia Dermatitis herpetiformis Depression or bipolar disorder Polyneuropathy Epilepsy Autoimmune myocarditis Chronic TTP Lymphoma Recurrent miscarriage Unexplained subfertility |
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