Open in new tab Disorder . Platelet...

Disorder	Platelet count	INR	APTT	TT	Fibrinogen	Other
Haemophilia A	Normal	Normal	↑	Normal	Normal	↓ VIII
Haemophilia B	Normal	Normal	↑	Normal	Normal	↓ IX
von Willebrand's disease	Normal (usually)	Normal	↑	Normal	Normal	↓ VIII, vWF, ↑ bleeding time
Liver disease	Normal or d	↑	↑	Normal	Normal or ↓	↓ V
Vitamin K deficiency	Normal	↑	↑	Normal	Normal	↓ II, VII, IX, X
DIC	Normal or ↓	↑	↑	↑	Normal or ↓	↑ FDPs, D-dimers, ↓ II, V, VIII
Massive transfusion	↓	↑	↑	Normalor ↑	Normal or ↓	Normal FDPs
Heparin (unfractionated)	Normal (rarely ↓)	Normal or i	↑	↑	Normal	↑ anti-Xa
Heparin (LMWH)	Normal (rarely ↓)	Normal	Normal	Normal	Normal	↑ anti-Xa
Warfarin	Normal	↑	↑	Normal	Normal	↓ II, VII, IX, X
Lupus anticoagulant	Normal	Normal or i	↑	Normal	Normal	DRVVT +ve, cardiolipin antibody

Disorder	Platelet count	INR	APTT	TT	Fibrinogen	Other
Haemophilia A	Normal	Normal	↑	Normal	Normal	↓ VIII
Haemophilia B	Normal	Normal	↑	Normal	Normal	↓ IX
von Willebrand's disease	Normal (usually)	Normal	↑	Normal	Normal	↓ VIII, vWF, ↑ bleeding time
Liver disease	Normal or d	↑	↑	Normal	Normal or ↓	↓ V
Vitamin K deficiency	Normal	↑	↑	Normal	Normal	↓ II, VII, IX, X
DIC	Normal or ↓	↑	↑	↑	Normal or ↓	↑ FDPs, D-dimers, ↓ II, V, VIII
Massive transfusion	↓	↑	↑	Normalor ↑	Normal or ↓	Normal FDPs
Heparin (unfractionated)	Normal (rarely ↓)	Normal or i	↑	↑	Normal	↑ anti-Xa
Heparin (LMWH)	Normal (rarely ↓)	Normal	Normal	Normal	Normal	↑ anti-Xa
Warfarin	Normal	↑	↑	Normal	Normal	↓ II, VII, IX, X
Lupus anticoagulant	Normal	Normal or i	↑	Normal	Normal	DRVVT +ve, cardiolipin antibody

vWF = von Willebrand's factor; FDPs = fibrin degradation products; DRVVT = dilute Russell's viper venom test.