Additional drug therapy may be not required if seizure stops and the cause of status epilepticus is treated

or

midazolam IV 0.2 mg/kg as bolus, continuous venous infusion of 0.1–0.6 mg/kg/h. Midazolam is well absorbed also IM and SC, and can be given at the same doses when venous access in not feasible;

midazolam as oral or atomized nasal preparations is also an alternative, at dose of 0.5 mg/kg, 2.5 mg for children, 6–12 months old; 5 mg 1–4 years; 7.5 mg 5–9 years; 10 mg for children 10 years or older,

or

IV diazepam 0.15–0.25 mg/kg, at rate of 5 mg/min, until a total of 20 mg in adults; may repeat once after 5min; rectal diazepam, 0.5 mg/kg or 2.5 mg for children 6–12 months old; 5 mg for 1–4 years; 7.5 mg 5–9 years; 10 mg for children 10 years, or more.

then

IV valproic acid 20–30 mg/kg infused over 15 minutes. However, higher doses, up to 25–60 mg/kg, at 3 mg/kg/min, have been used without serious side effects. This bolus must be followed by continuous infusion of 1–2 mg/kg/h*,

or

IV levetiracetam: 20–30 mg/kg in 100 mL of NaCl 0.9% or 5% glucose infused in 30 minutes: then, after 12 hours, the same in two divided doses.

If status epilepticus does not respond, consider

IV phenytoin 15 (in the elderly)–20 mg/kg, at infusion rate of no more than 50 mg/min in adults or 1 mg/kg/min in children (monitor for hypotension and electrocardigraphic QT prolongation), in normal saline, followed by a dose of 4–8 mg/kg/daily oral or IV.

If ineffective, give supplemental IV phenytoin 5 mg/kg, which can be repeated up to a total dose of 30 mg/kg.

* In some guidelines, phenytoin is suggested before valproic acid, but a number of papers have documented the successful use of IV valproate in status epilepticus, without serious cardiovascular side effects; fosphenytoin is better tolerated than phenytoin, but is not available in all countries.

and

phenobarbital IV, 20 mg/kg, infusion rate of 60 mg/min; caution with respiratory depression, mostly in patients treated before with benzodiazepines; if ineffective, supplemental IV phenobarbital 5–10 mg/kg

Otherwise refractory status epilepticus to be treated in intensive care unit, where the patient can be treated with general anaesthesia, propofol, pentobarbital, or others drugs (Fernandez and Claassen, 2012)