Table 2: Open in new tab Absolute T-CEUS...

Parameter

PRAE

UCP

P-value (UCP vs PRAE)

POST

P-value (POST vs PRAE)

PE (a.u.)

22 452 ± 27 812

17 621 ± 24 223

0.92

23 999 ± 27 603

0.99

10 057 ± 8989

6864 ± 4286

0.58

4953 ± 4504

0.32

8171 ± 9120

6996.8 ± 4496

0.75

3661 ± 3065

0.31

P-value (R vs L)

0.88

0.97

0.90

0.88

WiAUC (a.u.)

122 139 ± 149 278

96 098 ± 151 991

0.94

102 015 ± 103 909

0.95

36 982 ± 41 498

35 889 ± 32 623

0.99

14 952 ± 14 885

0.28

27 821 ± 37 336

24 154 ± 9049

0.86

9547 ± 7874

0.26

P-value (R vs L)

0.97

0.70

>0.99

RT (s)

7 ± 5

10 ± 4

0.97

7 ± 3

<0.05

5 ± 3

9 ± 6

0.03

5 ± 2

0.87

5 ± 2

6 ± 2

0.06

5 ± 2

0.87

P-value (R vs L)

0.81

0.76

0.89

mTT (s)

35 ± 16

44 ± 30

0.60

31 ± 12

0.84

26 ± 17

78 ± 63

0.06

36 ± 31

0.68

58 ± 53

43 ± 39

0.62

401 ± 37

0.61

P-value (R vs L)

0.07

0.51

0.68

TTP (s)

18 ± 9

20 ± 10

0.50

18 ± 6

0.99

6 ± 3

12 ± 8

0.04

6 ± 3

0.85

6 ± 2

8 ± 2

0.03

6 ± 2

0.71

P-value (R vs L)

0.87

0.69

0.96

WiR (a.u.)

4026 ± 5777

2908 ± 3489

0.84

4978 ± 6505

0.95

3528 ± 2468

2008 ± 1814

0.18

2044 ± 2232

0.28

2849 ± 2589

2205 ± 2002

0.45

1586 ± 1315

0.34

P-value (R vs L)

0.18

0.45

0.84

WiPI (a.u.)

13 933 ± 17 258

11 002 ± 15 144

0.93

14 776 ± 16 958

0.99

6625 ± 5932

4615 ± 2849

0.61

3262 ± 2956

0.32

5382 ± 5948

4590 ± 2890

0.75

2415 ± 2032

0.31

P-value (R vs L)

0.88

0.95

0.92

WoAUC (a.u.)

188 740 ± 234 088

198 334 ± 309 316

>0.99

145 279 ± 146 466

0.90

92 378 ± 105 754

44 989 ± 19 176

0.59

39 155 ± 38 826

0.38

77 226 ± 97 795

59 158 ± 16 852

0.54

25 765 ± 21 320

0.34

P-value (R vs L)

>0.99

0.61

>0.99

WiWoAUC(a.u.)

310 879 ± 383 283

307 529 ± 468 308

>0.99

247 294 ± 250 357

0.92

129 359 ± 147 234

64 381 ± 26 814

0.59

55 360 ± 54 167

0.38

108 330 ± 1 357 514

84 180 ± 26 242

0.56

36 168 ± 29 545

0.35

P-value (R vs L)

>0.99

0.64

0.99

FT (s)

11 ± 8

15 ± 6

0.05

10 ± 5

0.89

14 ± 7

21 ± 17

0.35

12 ± 7

0.48

12 ± 5

16 ± 8

0.23

10 ± 4

0.62

P-value (R vs L)

0.89

0.99

0.94

WoR (a.u.)

2198 ± 3187

1644 ± 1725

0.87

2899 ± 3899

0.92

964 ± 679

658 ± 806

0.46

643 ± 656

0.38

912 ± 801

693 ± 694

0.68

526 ± 352

0.48

P-value (R vs L)

0.82

0.98

0.76

Parameter

PRAE

UCP

P-value (UCP vs PRAE)

POST

P-value (POST vs PRAE)

PE (a.u.)

22 452 ± 27 812

17 621 ± 24 223

0.92

23 999 ± 27 603

0.99

10 057 ± 8989

6864 ± 4286

0.58

4953 ± 4504

0.32

8171 ± 9120

6996.8 ± 4496

0.75

3661 ± 3065

0.31

P-value (R vs L)

0.88

0.97

0.90

0.88

WiAUC (a.u.)

122 139 ± 149 278

96 098 ± 151 991

0.94

102 015 ± 103 909

0.95

36 982 ± 41 498

35 889 ± 32 623

0.99

14 952 ± 14 885

0.28

27 821 ± 37 336

24 154 ± 9049

0.86

9547 ± 7874

0.26

P-value (R vs L)

0.97

0.70

>0.99

RT (s)

7 ± 5

10 ± 4

0.97

7 ± 3

<0.05

5 ± 3

9 ± 6

0.03

5 ± 2

0.87

5 ± 2

6 ± 2

0.06

5 ± 2

0.87

P-value (R vs L)

0.81

0.76

0.89

mTT (s)

35 ± 16

44 ± 30

0.60

31 ± 12

0.84

26 ± 17

78 ± 63

0.06

36 ± 31

0.68

58 ± 53

43 ± 39

0.62

401 ± 37

0.61

P-value (R vs L)

0.07

0.51

0.68

TTP (s)

18 ± 9

20 ± 10

0.50

18 ± 6

0.99

6 ± 3

12 ± 8

0.04

6 ± 3

0.85

6 ± 2

8 ± 2

0.03

6 ± 2

0.71

P-value (R vs L)

0.87

0.69

0.96

WiR (a.u.)

4026 ± 5777

2908 ± 3489

0.84

4978 ± 6505

0.95

3528 ± 2468

2008 ± 1814

0.18

2044 ± 2232

0.28

2849 ± 2589

2205 ± 2002

0.45

1586 ± 1315

0.34

P-value (R vs L)

0.18

0.45

0.84

WiPI (a.u.)

13 933 ± 17 258

11 002 ± 15 144

0.93

14 776 ± 16 958

0.99

6625 ± 5932

4615 ± 2849

0.61

3262 ± 2956

0.32

5382 ± 5948

4590 ± 2890

0.75

2415 ± 2032

0.31

P-value (R vs L)

0.88

0.95

0.92

WoAUC (a.u.)

188 740 ± 234 088

198 334 ± 309 316

>0.99

145 279 ± 146 466

0.90

92 378 ± 105 754

44 989 ± 19 176

0.59

39 155 ± 38 826

0.38

77 226 ± 97 795

59 158 ± 16 852

0.54

25 765 ± 21 320

0.34

P-value (R vs L)

>0.99

0.61

>0.99

WiWoAUC(a.u.)

310 879 ± 383 283

307 529 ± 468 308

>0.99

247 294 ± 250 357

0.92

129 359 ± 147 234

64 381 ± 26 814

0.59

55 360 ± 54 167

0.38

108 330 ± 1 357 514

84 180 ± 26 242

0.56

36 168 ± 29 545

0.35

P-value (R vs L)

>0.99

0.64

0.99

FT (s)

11 ± 8

15 ± 6

0.05

10 ± 5

0.89

14 ± 7

21 ± 17

0.35

12 ± 7

0.48

12 ± 5

16 ± 8

0.23

10 ± 4

0.62

P-value (R vs L)

0.89

0.99

0.94

WoR (a.u.)

2198 ± 3187

1644 ± 1725

0.87

2899 ± 3899

0.92

964 ± 679

658 ± 806

0.46

643 ± 656

0.38

912 ± 801

693 ± 694

0.68

526 ± 352

0.48

P-value (R vs L)

0.82

0.98

0.76

Table 2:

Open in new tab

Absolute T-CEUS parameters

Parameter	PRAE	UCP	P-value (UCP vs PRAE)	POST	P-value (POST vs PRAE)
PE (a.u.)
V	22 452 ± 27 812	17 621 ± 24 223	0.92	23 999 ± 27 603	0.99
R	10 057 ± 8989	6864 ± 4286	0.58	4953 ± 4504	0.32
L	8171 ± 9120	6996.8 ± 4496	0.75	3661 ± 3065	0.31
P-value (R vs L)	0.88	0.97		0.90	0.88
WiAUC (a.u.)
V	122 139 ± 149 278	96 098 ± 151 991	0.94	102 015 ± 103 909	0.95
R	36 982 ± 41 498	35 889 ± 32 623	0.99	14 952 ± 14 885	0.28
L	27 821 ± 37 336	24 154 ± 9049	0.86	9547 ± 7874	0.26
P-value (R vs L)	0.97	0.70		>0.99
RT (s)
V	7 ± 5	10 ± 4	0.97	7 ± 3	<0.05
R	5 ± 3	9 ± 6	0.03	5 ± 2	0.87
L	5 ± 2	6 ± 2	0.06	5 ± 2	0.87
P-value (R vs L)	0.81	0.76		0.89
mTT (s)
V	35 ± 16	44 ± 30	0.60	31 ± 12	0.84
R	26 ± 17	78 ± 63	0.06	36 ± 31	0.68
L	58 ± 53	43 ± 39	0.62	401 ± 37	0.61
P-value (R vs L)	0.07	0.51		0.68
TTP (s)
V	18 ± 9	20 ± 10	0.50	18 ± 6	0.99
R	6 ± 3	12 ± 8	0.04	6 ± 3	0.85
L	6 ± 2	8 ± 2	0.03	6 ± 2	0.71
P-value (R vs L)	0.87	0.69		0.96
WiR (a.u.)
V	4026 ± 5777	2908 ± 3489	0.84	4978 ± 6505	0.95
R	3528 ± 2468	2008 ± 1814	0.18	2044 ± 2232	0.28
L	2849 ± 2589	2205 ± 2002	0.45	1586 ± 1315	0.34
P-value (R vs L)	0.18	0.45		0.84
WiPI (a.u.)
V	13 933 ± 17 258	11 002 ± 15 144	0.93	14 776 ± 16 958	0.99
R	6625 ± 5932	4615 ± 2849	0.61	3262 ± 2956	0.32
L	5382 ± 5948	4590 ± 2890	0.75	2415 ± 2032	0.31
P-value (R vs L)	0.88	0.95		0.92
WoAUC (a.u.)
V	188 740 ± 234 088	198 334 ± 309 316	>0.99	145 279 ± 146 466	0.90
R	92 378 ± 105 754	44 989 ± 19 176	0.59	39 155 ± 38 826	0.38
L	77 226 ± 97 795	59 158 ± 16 852	0.54	25 765 ± 21 320	0.34
P-value (R vs L)	>0.99	0.61		>0.99
WiWoAUC(a.u.)
V	310 879 ± 383 283	307 529 ± 468 308	>0.99	247 294 ± 250 357	0.92
R	129 359 ± 147 234	64 381 ± 26 814	0.59	55 360 ± 54 167	0.38
L	108 330 ± 1 357 514	84 180 ± 26 242	0.56	36 168 ± 29 545	0.35
P-value (R vs L)	>0.99	0.64		0.99
FT (s)
V	11 ± 8	15 ± 6	0.05	10 ± 5	0.89
R	14 ± 7	21 ± 17	0.35	12 ± 7	0.48
L	12 ± 5	16 ± 8	0.23	10 ± 4	0.62
P-value (R vs L)	0.89	0.99		0.94
WoR (a.u.)
V	2198 ± 3187	1644 ± 1725	0.87	2899 ± 3899	0.92
R	964 ± 679	658 ± 806	0.46	643 ± 656	0.38
L	912 ± 801	693 ± 694	0.68	526 ± 352	0.48
P-value (R vs L)	0.82	0.98		0.76

Parameter	PRAE	UCP	P-value (UCP vs PRAE)	POST	P-value (POST vs PRAE)
PE (a.u.)
V	22 452 ± 27 812	17 621 ± 24 223	0.92	23 999 ± 27 603	0.99
R	10 057 ± 8989	6864 ± 4286	0.58	4953 ± 4504	0.32
L	8171 ± 9120	6996.8 ± 4496	0.75	3661 ± 3065	0.31
P-value (R vs L)	0.88	0.97		0.90	0.88
WiAUC (a.u.)
V	122 139 ± 149 278	96 098 ± 151 991	0.94	102 015 ± 103 909	0.95
R	36 982 ± 41 498	35 889 ± 32 623	0.99	14 952 ± 14 885	0.28
L	27 821 ± 37 336	24 154 ± 9049	0.86	9547 ± 7874	0.26
P-value (R vs L)	0.97	0.70		>0.99
RT (s)
V	7 ± 5	10 ± 4	0.97	7 ± 3	<0.05
R	5 ± 3	9 ± 6	0.03	5 ± 2	0.87
L	5 ± 2	6 ± 2	0.06	5 ± 2	0.87
P-value (R vs L)	0.81	0.76		0.89
mTT (s)
V	35 ± 16	44 ± 30	0.60	31 ± 12	0.84
R	26 ± 17	78 ± 63	0.06	36 ± 31	0.68
L	58 ± 53	43 ± 39	0.62	401 ± 37	0.61
P-value (R vs L)	0.07	0.51		0.68
TTP (s)
V	18 ± 9	20 ± 10	0.50	18 ± 6	0.99
R	6 ± 3	12 ± 8	0.04	6 ± 3	0.85
L	6 ± 2	8 ± 2	0.03	6 ± 2	0.71
P-value (R vs L)	0.87	0.69		0.96
WiR (a.u.)
V	4026 ± 5777	2908 ± 3489	0.84	4978 ± 6505	0.95
R	3528 ± 2468	2008 ± 1814	0.18	2044 ± 2232	0.28
L	2849 ± 2589	2205 ± 2002	0.45	1586 ± 1315	0.34
P-value (R vs L)	0.18	0.45		0.84
WiPI (a.u.)
V	13 933 ± 17 258	11 002 ± 15 144	0.93	14 776 ± 16 958	0.99
R	6625 ± 5932	4615 ± 2849	0.61	3262 ± 2956	0.32
L	5382 ± 5948	4590 ± 2890	0.75	2415 ± 2032	0.31
P-value (R vs L)	0.88	0.95		0.92
WoAUC (a.u.)
V	188 740 ± 234 088	198 334 ± 309 316	>0.99	145 279 ± 146 466	0.90
R	92 378 ± 105 754	44 989 ± 19 176	0.59	39 155 ± 38 826	0.38
L	77 226 ± 97 795	59 158 ± 16 852	0.54	25 765 ± 21 320	0.34
P-value (R vs L)	>0.99	0.61		>0.99
WiWoAUC(a.u.)
V	310 879 ± 383 283	307 529 ± 468 308	>0.99	247 294 ± 250 357	0.92
R	129 359 ± 147 234	64 381 ± 26 814	0.59	55 360 ± 54 167	0.38
L	108 330 ± 1 357 514	84 180 ± 26 242	0.56	36 168 ± 29 545	0.35
P-value (R vs L)	>0.99	0.64		0.99
FT (s)
V	11 ± 8	15 ± 6	0.05	10 ± 5	0.89
R	14 ± 7	21 ± 17	0.35	12 ± 7	0.48
L	12 ± 5	16 ± 8	0.23	10 ± 4	0.62
P-value (R vs L)	0.89	0.99		0.94
WoR (a.u.)
V	2198 ± 3187	1644 ± 1725	0.87	2899 ± 3899	0.92
R	964 ± 679	658 ± 806	0.46	643 ± 656	0.38
L	912 ± 801	693 ± 694	0.68	526 ± 352	0.48
P-value (R vs L)	0.82	0.98		0.76

Absolute T-CEUS parameters: P-values are given for absolute side differences (column, P-value proportion) and absolute changes over time-points (P-value time-point, row).

FT: fall time; L: left hemisphere; mTT: mean-transit-time; PE: peak enhancement; POST: after skin suture; PRAE: before skin incision; R: right hemisphere; RT: rise time; T-CEUS: transfontanellar contrast-enhanced ultrasound; TTP: time-to-peak; V: superior sagittal venous sinus; UCP: unilateral cerebral perfusion; WiAUC: wash-in-area-under-the-curve; WiPI: wash-in perfusion index; WiR: wash-in rate; WiWoAUC: wash-in-wash-out-area-under-the-curve; WoAUC: wash-out-area-under-the-curve; WoR: wash-out rate.

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