Risk of thoracic aortic aneurysms in the GCA cohort compared with the reference cohort stratified by baseline characteristics
| . | . | 10 years following index . | 15 years following index . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Number . | Crude . | Adjusteda . | Crude . | Adjusteda . | ||||||
| . | . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . |
| Overall | 9908 | 1.1 (0.9, 1.4) | 1.0 (0.7, 1.2) | 6.52 (4.90, 8.67) | 1.0 (0.7, 1.2) | 7.39 (5.23, 10.5) | 1.9 (1.5, 2.2) | 1.6 (1.2, 2.0) | 7.53 (5.81, 9.76) | 1.6 (1.2, 2.0) | 11.2 (7.41, 16.9) |
| Sex | |||||||||||
| Male | 3307 | 0.9 (0.5, 1.4) | 0.7 (0.3, 1.1) | 3.73 (2.23, 6.26) | 0.7 (0.3, 1.1) | 3.86 (2.26, 6.60) | 1.3 (0.7, 1.8) | 1.0 (0.4, 1.5) | 4.06 (2.49, 6.62) | 1.0 (0.4, 1.5) | 5.18 (2.56, 10.5) |
| Female | 6601 | 1.2 (0.9, 1.5) | 1.1 (0.8, 1.4) | 8.87 (6.23, 12.6) | 1.1 (0.7, 1.4) | 9.77 (6.69, 14.3) | 2.1 (1.6, 2.6) | 1.9 (1.4, 2.4) | 9.83 (7.17, 13.5) | 1.9 (1.4, 2.4) | 13.2 (8.53, 20.5) |
| Age | |||||||||||
| <70 years | 3448 | 1.7 (1.2, 2.3) | 1.6 (1.0, 2.1) | 11.1 (7.11, 17.4) | 1.6 (1.0, 2.1) | 12.6 (7.16, 22.3) | 3.4 (2.5, 4.3) | 3.2 (2.3, 4.1) | 14.7 (9.86, 21.8) | 3.2 (2.3, 4.1) | 17.7 (10.6, 29.7) |
| ≥70 years | 6460 | 0.8 (0.6, 1.1) | 0.6 (0.4, 0.9) | 4.43 (3.01, 6.53) | 0.6 (0.4, 0.9) | 4.68 (2.99, 7.33) | 1.0 (0.7, 1.3) | 0.8 (0.5, 1.1) | 4.08 (2.83, 5.88) | 0.8 (0.5, 1.1) | 4.54 (2.89, 7.13) |
| CCI | |||||||||||
| 0 | 6563 | 1.2 (0.9, 1.6) | 1.1 (0.7, 1.4) | 7.04 (5.00, 9.12) | 1.1 (0.7, 1.4) | 7.60 (5.06, 11.4) | 2.3 (1.8, 2.8) | 2.0 (1.5, 2.5) | 8.55 (6.30, 11.6) | 2.0 (1.5, 2.5) | 12.0 (7.67, 18.8) |
| 1 | 1613 | 1.2 (0.6, 1.9) | 1.0 (0.4, 1.7) | 7.30 (3.64, 14.6) | 1.0 (0.4, 1.7) | 8.45 (3.98, 17.9) | 1.4 (0.7, 2.1) | 1.2 (0.5, 1.9) | 6.65 (3.42, 12.9) | 1.2 (0.5, 1.9) | 8.43 (3.92, 18.1) |
| ≥2 | 1732 | 0.7 (0.2, 1.2) | 0.5 (0.0, 1.0) | 3.86 (1.69, 8.80) | 0.5 (0.0, 1.0) | 4.45 (1.50, 13.2) | 0.7 (0.2, 1.2) | 0.5 (−0.0, 1.0) | 3.36 (1.52, 7.40) | 0.5 (−0.0, 1.0) | 3.85 (1.43, 10.3) |
| TAB | |||||||||||
| Positive | 3406 | 1.8 (1.3, 2.3) | 1.7 (1.1, 2.2) | 12.9 (8.38, 19.8) | 1.7 (1.1, 2.2) | 13.1 (8.43, 20.2) | 2.9 (2.1, 3.6) | 2.7 (1.9, 3.4) | 14.4 (9.76, 21.1) | 2.7 (1.9, 3.4) | 14.4 (9.64, 21.6) |
| Negative | 3368 | 0.6 (0.3, 0.9) | 0.5 (0.1, 0.8) | 3.85 (2.14, 6.91) | 0.5 (0.1, 0.8) | 4.07 (2.22, 7.48) | 1.1 (0.6, 1.6) | 0.9 (0.4, 1.3) | 4.67 (2.77, 7.88) | 0.9 (0.4, 1.4) | 5.25 (2.96, 9.32) |
| None | 3134 | 0.9 (0.4, 1.3) | 0.6 (0.2, 1.1) | 3.57 (1.99, 6.39) | 0.6 (0.2, 1.1) | 3.89 (2.04, 7.43) | 1.3 (0.7, 2.0) | 1.0 (0.4, 1.6) | 4.00 (2.31, 6.92) | 1.0 (0.4, 1.6) | 4.43 (2.42, 8.11) |
| Combinations | |||||||||||
| Female, <70 years | 2228 | 2.0 (1.3, 2.7) | 1.9 (1.2, 2.6) | 18.1 (10.1, 32.4) | 1.9 (1.2, 2.6) | 18.0 (9.87, 32.7) | 4.1 (2.9, 5.3) | 3.9 (2.7, 5.1) | 20.5 (12.3, 34.3) | 3.9 (2.7, 5.1) | 20.3 (12.0, 34.5) |
| Female, positive TAB | 2330 | 1.8 (1.2, 2.4) | 1.7 (1.0, 2.3) | 12.6 (7.58, 21.0) | 1.7 (1.0, 2.3) | 12.9 (7.64, 21.8) | 3.2 (2.2, 4.1) | 2.9 (2.0, 3.9) | 14.9 (9.51, 23.4) | 2.9 (2.0, 3.9) | 15.0 (9.35, 24.0) |
| <70 years, positive TAB | 1018 | 3.0 (1.7, 4.2) | 2.9 (1.6, 4.1) | 30.1 (13.5, 67.3) | 2.9 (1.6, 4.1) | 29.6 (12.9, 67.9) | 5.3 (3.5, 7.2) | 5.2 (3.3, 7.0) | 37.8 (18.2, 78.5) | 5.2 (3.3, 7.0) | 38.6 (17.9, 83.3) |
| Female, <70 years, positive TAB | 667 | 3.2 (1.7, 4.8) | 3.1 (1.6, 4.7) | 34.9 (12.9, 94.6) | 3.1 (1.6, 4.7) | 41.0 (12.2, 138) | 6.2 (3.8, 8.7) | 6.1 (3.6, 8.5) | 39.7 (16.7, 94.6) | 6.1 (3.6, 8.5) | 39.9 (16.2, 98.3) |
| . | . | 10 years following index . | 15 years following index . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Number . | Crude . | Adjusteda . | Crude . | Adjusteda . | ||||||
| . | . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . |
| Overall | 9908 | 1.1 (0.9, 1.4) | 1.0 (0.7, 1.2) | 6.52 (4.90, 8.67) | 1.0 (0.7, 1.2) | 7.39 (5.23, 10.5) | 1.9 (1.5, 2.2) | 1.6 (1.2, 2.0) | 7.53 (5.81, 9.76) | 1.6 (1.2, 2.0) | 11.2 (7.41, 16.9) |
| Sex | |||||||||||
| Male | 3307 | 0.9 (0.5, 1.4) | 0.7 (0.3, 1.1) | 3.73 (2.23, 6.26) | 0.7 (0.3, 1.1) | 3.86 (2.26, 6.60) | 1.3 (0.7, 1.8) | 1.0 (0.4, 1.5) | 4.06 (2.49, 6.62) | 1.0 (0.4, 1.5) | 5.18 (2.56, 10.5) |
| Female | 6601 | 1.2 (0.9, 1.5) | 1.1 (0.8, 1.4) | 8.87 (6.23, 12.6) | 1.1 (0.7, 1.4) | 9.77 (6.69, 14.3) | 2.1 (1.6, 2.6) | 1.9 (1.4, 2.4) | 9.83 (7.17, 13.5) | 1.9 (1.4, 2.4) | 13.2 (8.53, 20.5) |
| Age | |||||||||||
| <70 years | 3448 | 1.7 (1.2, 2.3) | 1.6 (1.0, 2.1) | 11.1 (7.11, 17.4) | 1.6 (1.0, 2.1) | 12.6 (7.16, 22.3) | 3.4 (2.5, 4.3) | 3.2 (2.3, 4.1) | 14.7 (9.86, 21.8) | 3.2 (2.3, 4.1) | 17.7 (10.6, 29.7) |
| ≥70 years | 6460 | 0.8 (0.6, 1.1) | 0.6 (0.4, 0.9) | 4.43 (3.01, 6.53) | 0.6 (0.4, 0.9) | 4.68 (2.99, 7.33) | 1.0 (0.7, 1.3) | 0.8 (0.5, 1.1) | 4.08 (2.83, 5.88) | 0.8 (0.5, 1.1) | 4.54 (2.89, 7.13) |
| CCI | |||||||||||
| 0 | 6563 | 1.2 (0.9, 1.6) | 1.1 (0.7, 1.4) | 7.04 (5.00, 9.12) | 1.1 (0.7, 1.4) | 7.60 (5.06, 11.4) | 2.3 (1.8, 2.8) | 2.0 (1.5, 2.5) | 8.55 (6.30, 11.6) | 2.0 (1.5, 2.5) | 12.0 (7.67, 18.8) |
| 1 | 1613 | 1.2 (0.6, 1.9) | 1.0 (0.4, 1.7) | 7.30 (3.64, 14.6) | 1.0 (0.4, 1.7) | 8.45 (3.98, 17.9) | 1.4 (0.7, 2.1) | 1.2 (0.5, 1.9) | 6.65 (3.42, 12.9) | 1.2 (0.5, 1.9) | 8.43 (3.92, 18.1) |
| ≥2 | 1732 | 0.7 (0.2, 1.2) | 0.5 (0.0, 1.0) | 3.86 (1.69, 8.80) | 0.5 (0.0, 1.0) | 4.45 (1.50, 13.2) | 0.7 (0.2, 1.2) | 0.5 (−0.0, 1.0) | 3.36 (1.52, 7.40) | 0.5 (−0.0, 1.0) | 3.85 (1.43, 10.3) |
| TAB | |||||||||||
| Positive | 3406 | 1.8 (1.3, 2.3) | 1.7 (1.1, 2.2) | 12.9 (8.38, 19.8) | 1.7 (1.1, 2.2) | 13.1 (8.43, 20.2) | 2.9 (2.1, 3.6) | 2.7 (1.9, 3.4) | 14.4 (9.76, 21.1) | 2.7 (1.9, 3.4) | 14.4 (9.64, 21.6) |
| Negative | 3368 | 0.6 (0.3, 0.9) | 0.5 (0.1, 0.8) | 3.85 (2.14, 6.91) | 0.5 (0.1, 0.8) | 4.07 (2.22, 7.48) | 1.1 (0.6, 1.6) | 0.9 (0.4, 1.3) | 4.67 (2.77, 7.88) | 0.9 (0.4, 1.4) | 5.25 (2.96, 9.32) |
| None | 3134 | 0.9 (0.4, 1.3) | 0.6 (0.2, 1.1) | 3.57 (1.99, 6.39) | 0.6 (0.2, 1.1) | 3.89 (2.04, 7.43) | 1.3 (0.7, 2.0) | 1.0 (0.4, 1.6) | 4.00 (2.31, 6.92) | 1.0 (0.4, 1.6) | 4.43 (2.42, 8.11) |
| Combinations | |||||||||||
| Female, <70 years | 2228 | 2.0 (1.3, 2.7) | 1.9 (1.2, 2.6) | 18.1 (10.1, 32.4) | 1.9 (1.2, 2.6) | 18.0 (9.87, 32.7) | 4.1 (2.9, 5.3) | 3.9 (2.7, 5.1) | 20.5 (12.3, 34.3) | 3.9 (2.7, 5.1) | 20.3 (12.0, 34.5) |
| Female, positive TAB | 2330 | 1.8 (1.2, 2.4) | 1.7 (1.0, 2.3) | 12.6 (7.58, 21.0) | 1.7 (1.0, 2.3) | 12.9 (7.64, 21.8) | 3.2 (2.2, 4.1) | 2.9 (2.0, 3.9) | 14.9 (9.51, 23.4) | 2.9 (2.0, 3.9) | 15.0 (9.35, 24.0) |
| <70 years, positive TAB | 1018 | 3.0 (1.7, 4.2) | 2.9 (1.6, 4.1) | 30.1 (13.5, 67.3) | 2.9 (1.6, 4.1) | 29.6 (12.9, 67.9) | 5.3 (3.5, 7.2) | 5.2 (3.3, 7.0) | 37.8 (18.2, 78.5) | 5.2 (3.3, 7.0) | 38.6 (17.9, 83.3) |
| Female, <70 years, positive TAB | 667 | 3.2 (1.7, 4.8) | 3.1 (1.6, 4.7) | 34.9 (12.9, 94.6) | 3.1 (1.6, 4.7) | 41.0 (12.2, 138) | 6.2 (3.8, 8.7) | 6.1 (3.6, 8.5) | 39.7 (16.7, 94.6) | 6.1 (3.6, 8.5) | 39.9 (16.2, 98.3) |
Values are expressed as cumulative incidence proportions (CIP), risk differences (RDs) and as relative risks (RRs), 10 and 15 years after start of follow-up with 95% CIs. Index date was defined as the date of redeeming the third prednisolone prescription. Values were calculated among 9908 patients with GCA compared with 98 204 individuals from the general population. aAdjusted for Charlson Comorbidity Index. In this stratification matching was broken. CCI: Charlson Comorbidity Index; TAB: temporal artery biopsy.
Risk of thoracic aortic aneurysms in the GCA cohort compared with the reference cohort stratified by baseline characteristics
| . | . | 10 years following index . | 15 years following index . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Number . | Crude . | Adjusteda . | Crude . | Adjusteda . | ||||||
| . | . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . |
| Overall | 9908 | 1.1 (0.9, 1.4) | 1.0 (0.7, 1.2) | 6.52 (4.90, 8.67) | 1.0 (0.7, 1.2) | 7.39 (5.23, 10.5) | 1.9 (1.5, 2.2) | 1.6 (1.2, 2.0) | 7.53 (5.81, 9.76) | 1.6 (1.2, 2.0) | 11.2 (7.41, 16.9) |
| Sex | |||||||||||
| Male | 3307 | 0.9 (0.5, 1.4) | 0.7 (0.3, 1.1) | 3.73 (2.23, 6.26) | 0.7 (0.3, 1.1) | 3.86 (2.26, 6.60) | 1.3 (0.7, 1.8) | 1.0 (0.4, 1.5) | 4.06 (2.49, 6.62) | 1.0 (0.4, 1.5) | 5.18 (2.56, 10.5) |
| Female | 6601 | 1.2 (0.9, 1.5) | 1.1 (0.8, 1.4) | 8.87 (6.23, 12.6) | 1.1 (0.7, 1.4) | 9.77 (6.69, 14.3) | 2.1 (1.6, 2.6) | 1.9 (1.4, 2.4) | 9.83 (7.17, 13.5) | 1.9 (1.4, 2.4) | 13.2 (8.53, 20.5) |
| Age | |||||||||||
| <70 years | 3448 | 1.7 (1.2, 2.3) | 1.6 (1.0, 2.1) | 11.1 (7.11, 17.4) | 1.6 (1.0, 2.1) | 12.6 (7.16, 22.3) | 3.4 (2.5, 4.3) | 3.2 (2.3, 4.1) | 14.7 (9.86, 21.8) | 3.2 (2.3, 4.1) | 17.7 (10.6, 29.7) |
| ≥70 years | 6460 | 0.8 (0.6, 1.1) | 0.6 (0.4, 0.9) | 4.43 (3.01, 6.53) | 0.6 (0.4, 0.9) | 4.68 (2.99, 7.33) | 1.0 (0.7, 1.3) | 0.8 (0.5, 1.1) | 4.08 (2.83, 5.88) | 0.8 (0.5, 1.1) | 4.54 (2.89, 7.13) |
| CCI | |||||||||||
| 0 | 6563 | 1.2 (0.9, 1.6) | 1.1 (0.7, 1.4) | 7.04 (5.00, 9.12) | 1.1 (0.7, 1.4) | 7.60 (5.06, 11.4) | 2.3 (1.8, 2.8) | 2.0 (1.5, 2.5) | 8.55 (6.30, 11.6) | 2.0 (1.5, 2.5) | 12.0 (7.67, 18.8) |
| 1 | 1613 | 1.2 (0.6, 1.9) | 1.0 (0.4, 1.7) | 7.30 (3.64, 14.6) | 1.0 (0.4, 1.7) | 8.45 (3.98, 17.9) | 1.4 (0.7, 2.1) | 1.2 (0.5, 1.9) | 6.65 (3.42, 12.9) | 1.2 (0.5, 1.9) | 8.43 (3.92, 18.1) |
| ≥2 | 1732 | 0.7 (0.2, 1.2) | 0.5 (0.0, 1.0) | 3.86 (1.69, 8.80) | 0.5 (0.0, 1.0) | 4.45 (1.50, 13.2) | 0.7 (0.2, 1.2) | 0.5 (−0.0, 1.0) | 3.36 (1.52, 7.40) | 0.5 (−0.0, 1.0) | 3.85 (1.43, 10.3) |
| TAB | |||||||||||
| Positive | 3406 | 1.8 (1.3, 2.3) | 1.7 (1.1, 2.2) | 12.9 (8.38, 19.8) | 1.7 (1.1, 2.2) | 13.1 (8.43, 20.2) | 2.9 (2.1, 3.6) | 2.7 (1.9, 3.4) | 14.4 (9.76, 21.1) | 2.7 (1.9, 3.4) | 14.4 (9.64, 21.6) |
| Negative | 3368 | 0.6 (0.3, 0.9) | 0.5 (0.1, 0.8) | 3.85 (2.14, 6.91) | 0.5 (0.1, 0.8) | 4.07 (2.22, 7.48) | 1.1 (0.6, 1.6) | 0.9 (0.4, 1.3) | 4.67 (2.77, 7.88) | 0.9 (0.4, 1.4) | 5.25 (2.96, 9.32) |
| None | 3134 | 0.9 (0.4, 1.3) | 0.6 (0.2, 1.1) | 3.57 (1.99, 6.39) | 0.6 (0.2, 1.1) | 3.89 (2.04, 7.43) | 1.3 (0.7, 2.0) | 1.0 (0.4, 1.6) | 4.00 (2.31, 6.92) | 1.0 (0.4, 1.6) | 4.43 (2.42, 8.11) |
| Combinations | |||||||||||
| Female, <70 years | 2228 | 2.0 (1.3, 2.7) | 1.9 (1.2, 2.6) | 18.1 (10.1, 32.4) | 1.9 (1.2, 2.6) | 18.0 (9.87, 32.7) | 4.1 (2.9, 5.3) | 3.9 (2.7, 5.1) | 20.5 (12.3, 34.3) | 3.9 (2.7, 5.1) | 20.3 (12.0, 34.5) |
| Female, positive TAB | 2330 | 1.8 (1.2, 2.4) | 1.7 (1.0, 2.3) | 12.6 (7.58, 21.0) | 1.7 (1.0, 2.3) | 12.9 (7.64, 21.8) | 3.2 (2.2, 4.1) | 2.9 (2.0, 3.9) | 14.9 (9.51, 23.4) | 2.9 (2.0, 3.9) | 15.0 (9.35, 24.0) |
| <70 years, positive TAB | 1018 | 3.0 (1.7, 4.2) | 2.9 (1.6, 4.1) | 30.1 (13.5, 67.3) | 2.9 (1.6, 4.1) | 29.6 (12.9, 67.9) | 5.3 (3.5, 7.2) | 5.2 (3.3, 7.0) | 37.8 (18.2, 78.5) | 5.2 (3.3, 7.0) | 38.6 (17.9, 83.3) |
| Female, <70 years, positive TAB | 667 | 3.2 (1.7, 4.8) | 3.1 (1.6, 4.7) | 34.9 (12.9, 94.6) | 3.1 (1.6, 4.7) | 41.0 (12.2, 138) | 6.2 (3.8, 8.7) | 6.1 (3.6, 8.5) | 39.7 (16.7, 94.6) | 6.1 (3.6, 8.5) | 39.9 (16.2, 98.3) |
| . | . | 10 years following index . | 15 years following index . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Number . | Crude . | Adjusteda . | Crude . | Adjusteda . | ||||||
| . | . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . | CIP (95% CI) . | RD (95% CI) . | RR (95% CI) . | RD (95% CI) . | RR (95% CI) . |
| Overall | 9908 | 1.1 (0.9, 1.4) | 1.0 (0.7, 1.2) | 6.52 (4.90, 8.67) | 1.0 (0.7, 1.2) | 7.39 (5.23, 10.5) | 1.9 (1.5, 2.2) | 1.6 (1.2, 2.0) | 7.53 (5.81, 9.76) | 1.6 (1.2, 2.0) | 11.2 (7.41, 16.9) |
| Sex | |||||||||||
| Male | 3307 | 0.9 (0.5, 1.4) | 0.7 (0.3, 1.1) | 3.73 (2.23, 6.26) | 0.7 (0.3, 1.1) | 3.86 (2.26, 6.60) | 1.3 (0.7, 1.8) | 1.0 (0.4, 1.5) | 4.06 (2.49, 6.62) | 1.0 (0.4, 1.5) | 5.18 (2.56, 10.5) |
| Female | 6601 | 1.2 (0.9, 1.5) | 1.1 (0.8, 1.4) | 8.87 (6.23, 12.6) | 1.1 (0.7, 1.4) | 9.77 (6.69, 14.3) | 2.1 (1.6, 2.6) | 1.9 (1.4, 2.4) | 9.83 (7.17, 13.5) | 1.9 (1.4, 2.4) | 13.2 (8.53, 20.5) |
| Age | |||||||||||
| <70 years | 3448 | 1.7 (1.2, 2.3) | 1.6 (1.0, 2.1) | 11.1 (7.11, 17.4) | 1.6 (1.0, 2.1) | 12.6 (7.16, 22.3) | 3.4 (2.5, 4.3) | 3.2 (2.3, 4.1) | 14.7 (9.86, 21.8) | 3.2 (2.3, 4.1) | 17.7 (10.6, 29.7) |
| ≥70 years | 6460 | 0.8 (0.6, 1.1) | 0.6 (0.4, 0.9) | 4.43 (3.01, 6.53) | 0.6 (0.4, 0.9) | 4.68 (2.99, 7.33) | 1.0 (0.7, 1.3) | 0.8 (0.5, 1.1) | 4.08 (2.83, 5.88) | 0.8 (0.5, 1.1) | 4.54 (2.89, 7.13) |
| CCI | |||||||||||
| 0 | 6563 | 1.2 (0.9, 1.6) | 1.1 (0.7, 1.4) | 7.04 (5.00, 9.12) | 1.1 (0.7, 1.4) | 7.60 (5.06, 11.4) | 2.3 (1.8, 2.8) | 2.0 (1.5, 2.5) | 8.55 (6.30, 11.6) | 2.0 (1.5, 2.5) | 12.0 (7.67, 18.8) |
| 1 | 1613 | 1.2 (0.6, 1.9) | 1.0 (0.4, 1.7) | 7.30 (3.64, 14.6) | 1.0 (0.4, 1.7) | 8.45 (3.98, 17.9) | 1.4 (0.7, 2.1) | 1.2 (0.5, 1.9) | 6.65 (3.42, 12.9) | 1.2 (0.5, 1.9) | 8.43 (3.92, 18.1) |
| ≥2 | 1732 | 0.7 (0.2, 1.2) | 0.5 (0.0, 1.0) | 3.86 (1.69, 8.80) | 0.5 (0.0, 1.0) | 4.45 (1.50, 13.2) | 0.7 (0.2, 1.2) | 0.5 (−0.0, 1.0) | 3.36 (1.52, 7.40) | 0.5 (−0.0, 1.0) | 3.85 (1.43, 10.3) |
| TAB | |||||||||||
| Positive | 3406 | 1.8 (1.3, 2.3) | 1.7 (1.1, 2.2) | 12.9 (8.38, 19.8) | 1.7 (1.1, 2.2) | 13.1 (8.43, 20.2) | 2.9 (2.1, 3.6) | 2.7 (1.9, 3.4) | 14.4 (9.76, 21.1) | 2.7 (1.9, 3.4) | 14.4 (9.64, 21.6) |
| Negative | 3368 | 0.6 (0.3, 0.9) | 0.5 (0.1, 0.8) | 3.85 (2.14, 6.91) | 0.5 (0.1, 0.8) | 4.07 (2.22, 7.48) | 1.1 (0.6, 1.6) | 0.9 (0.4, 1.3) | 4.67 (2.77, 7.88) | 0.9 (0.4, 1.4) | 5.25 (2.96, 9.32) |
| None | 3134 | 0.9 (0.4, 1.3) | 0.6 (0.2, 1.1) | 3.57 (1.99, 6.39) | 0.6 (0.2, 1.1) | 3.89 (2.04, 7.43) | 1.3 (0.7, 2.0) | 1.0 (0.4, 1.6) | 4.00 (2.31, 6.92) | 1.0 (0.4, 1.6) | 4.43 (2.42, 8.11) |
| Combinations | |||||||||||
| Female, <70 years | 2228 | 2.0 (1.3, 2.7) | 1.9 (1.2, 2.6) | 18.1 (10.1, 32.4) | 1.9 (1.2, 2.6) | 18.0 (9.87, 32.7) | 4.1 (2.9, 5.3) | 3.9 (2.7, 5.1) | 20.5 (12.3, 34.3) | 3.9 (2.7, 5.1) | 20.3 (12.0, 34.5) |
| Female, positive TAB | 2330 | 1.8 (1.2, 2.4) | 1.7 (1.0, 2.3) | 12.6 (7.58, 21.0) | 1.7 (1.0, 2.3) | 12.9 (7.64, 21.8) | 3.2 (2.2, 4.1) | 2.9 (2.0, 3.9) | 14.9 (9.51, 23.4) | 2.9 (2.0, 3.9) | 15.0 (9.35, 24.0) |
| <70 years, positive TAB | 1018 | 3.0 (1.7, 4.2) | 2.9 (1.6, 4.1) | 30.1 (13.5, 67.3) | 2.9 (1.6, 4.1) | 29.6 (12.9, 67.9) | 5.3 (3.5, 7.2) | 5.2 (3.3, 7.0) | 37.8 (18.2, 78.5) | 5.2 (3.3, 7.0) | 38.6 (17.9, 83.3) |
| Female, <70 years, positive TAB | 667 | 3.2 (1.7, 4.8) | 3.1 (1.6, 4.7) | 34.9 (12.9, 94.6) | 3.1 (1.6, 4.7) | 41.0 (12.2, 138) | 6.2 (3.8, 8.7) | 6.1 (3.6, 8.5) | 39.7 (16.7, 94.6) | 6.1 (3.6, 8.5) | 39.9 (16.2, 98.3) |
Values are expressed as cumulative incidence proportions (CIP), risk differences (RDs) and as relative risks (RRs), 10 and 15 years after start of follow-up with 95% CIs. Index date was defined as the date of redeeming the third prednisolone prescription. Values were calculated among 9908 patients with GCA compared with 98 204 individuals from the general population. aAdjusted for Charlson Comorbidity Index. In this stratification matching was broken. CCI: Charlson Comorbidity Index; TAB: temporal artery biopsy.
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