Univariable- and Multivariable- Associations Between CTX and Outcome Measures
| . | . | . | Univariable Regression . | . | Multivariable Regression . | . |
|---|---|---|---|---|---|---|
| Variable . | n . | Median (IQR), Mean ± SD, n (%) . | β-Coefficient (95% CI) . | p Value . | β-Coefficient (95% CI) . | p Value . |
| ALM/BMI* | 288 | 0.57 (0.50, 0.69) | 1.04 (1.00, 1.08) | .033 | 1.00 (0.96, 1.05) | .884 |
| Handgrip strength (kg) | 285 | 22.82 ± 8.34 | 0.65 (0.49, 0.87) | .003 | 0.80 (0.59, 1.10) | .173 |
| Total SPPB (points) | 283 | 6.99 ± 2.84 | 0.94 (0.91, 0.96) | <.001 | 0.95 (0.92, 0.98) | .002 |
| SPPB—gait speed (m/s) | 280 | 0.74 ± 0.29 | 1.00 (0.99, 1.01) | .927 | 0.99 (0.98, 1.01) | .381 |
| SPPB—balance (points) | 282 | 4 (2, 4) | 0.87 (0.81, 0.93) | <.001 | 0.92 (0.86, 0.99) | .035 |
| SPPB—sit-to-stand (s)* | 177 | 16.62 (14.12, 21.30) | 1.03 (1.00, 1.05) | .030 | 1.02 (1.00, 1.05) | .080 |
| SPPB—sit-to-stand | 282 | |||||
| Unable | 102 (36.2%) | Reference | Reference | |||
| Able | 180 (63.8%) | 0.75 (0.63, 0.89) | .001 | 0.80 (0.67, 0.95) | .013 | |
| TUG (s)* | 267 | 15.77 (11.69, 21.21) | 1.04 (1.02, 1.06) | <.001 | 1.03 (1.00, 1.05) | .016 |
| . | . | . | Univariable Regression . | . | Multivariable Regression . | . |
|---|---|---|---|---|---|---|
| Variable . | n . | Median (IQR), Mean ± SD, n (%) . | β-Coefficient (95% CI) . | p Value . | β-Coefficient (95% CI) . | p Value . |
| ALM/BMI* | 288 | 0.57 (0.50, 0.69) | 1.04 (1.00, 1.08) | .033 | 1.00 (0.96, 1.05) | .884 |
| Handgrip strength (kg) | 285 | 22.82 ± 8.34 | 0.65 (0.49, 0.87) | .003 | 0.80 (0.59, 1.10) | .173 |
| Total SPPB (points) | 283 | 6.99 ± 2.84 | 0.94 (0.91, 0.96) | <.001 | 0.95 (0.92, 0.98) | .002 |
| SPPB—gait speed (m/s) | 280 | 0.74 ± 0.29 | 1.00 (0.99, 1.01) | .927 | 0.99 (0.98, 1.01) | .381 |
| SPPB—balance (points) | 282 | 4 (2, 4) | 0.87 (0.81, 0.93) | <.001 | 0.92 (0.86, 0.99) | .035 |
| SPPB—sit-to-stand (s)* | 177 | 16.62 (14.12, 21.30) | 1.03 (1.00, 1.05) | .030 | 1.02 (1.00, 1.05) | .080 |
| SPPB—sit-to-stand | 282 | |||||
| Unable | 102 (36.2%) | Reference | Reference | |||
| Able | 180 (63.8%) | 0.75 (0.63, 0.89) | .001 | 0.80 (0.67, 0.95) | .013 | |
| TUG (s)* | 267 | 15.77 (11.69, 21.21) | 1.04 (1.02, 1.06) | <.001 | 1.03 (1.00, 1.05) | .016 |
Notes: Multivariable linear regression adjusted for age, sex, smoking, malnutrition status, CCI, GDS, eGFR, and PTH levels. β-Coefficients with 95% CI represent the fold change in CTX when variable increases in 1 unit. In cases where variable was transformed (marked by asterisk*), the β-coefficient with 95% CI represents the fold change in CTX with 10% increase in variable. ALM = appendicular lean mass; BMI = body mass index; CCI = Charlson Comorbidity Index; CI = confidence interval; CTX = serum cross-linked C-telopeptides of type I collagen; eGFR = estimated glomerular filtration rate; GDS = Geriatric Depression Scale; IQR = interquartile range; PTH = parathyroid hormone; SD = standard deviation; SPPB = short physical performance battery; TUG = Timed Up and Go.
Univariable- and Multivariable- Associations Between CTX and Outcome Measures
| . | . | . | Univariable Regression . | . | Multivariable Regression . | . |
|---|---|---|---|---|---|---|
| Variable . | n . | Median (IQR), Mean ± SD, n (%) . | β-Coefficient (95% CI) . | p Value . | β-Coefficient (95% CI) . | p Value . |
| ALM/BMI* | 288 | 0.57 (0.50, 0.69) | 1.04 (1.00, 1.08) | .033 | 1.00 (0.96, 1.05) | .884 |
| Handgrip strength (kg) | 285 | 22.82 ± 8.34 | 0.65 (0.49, 0.87) | .003 | 0.80 (0.59, 1.10) | .173 |
| Total SPPB (points) | 283 | 6.99 ± 2.84 | 0.94 (0.91, 0.96) | <.001 | 0.95 (0.92, 0.98) | .002 |
| SPPB—gait speed (m/s) | 280 | 0.74 ± 0.29 | 1.00 (0.99, 1.01) | .927 | 0.99 (0.98, 1.01) | .381 |
| SPPB—balance (points) | 282 | 4 (2, 4) | 0.87 (0.81, 0.93) | <.001 | 0.92 (0.86, 0.99) | .035 |
| SPPB—sit-to-stand (s)* | 177 | 16.62 (14.12, 21.30) | 1.03 (1.00, 1.05) | .030 | 1.02 (1.00, 1.05) | .080 |
| SPPB—sit-to-stand | 282 | |||||
| Unable | 102 (36.2%) | Reference | Reference | |||
| Able | 180 (63.8%) | 0.75 (0.63, 0.89) | .001 | 0.80 (0.67, 0.95) | .013 | |
| TUG (s)* | 267 | 15.77 (11.69, 21.21) | 1.04 (1.02, 1.06) | <.001 | 1.03 (1.00, 1.05) | .016 |
| . | . | . | Univariable Regression . | . | Multivariable Regression . | . |
|---|---|---|---|---|---|---|
| Variable . | n . | Median (IQR), Mean ± SD, n (%) . | β-Coefficient (95% CI) . | p Value . | β-Coefficient (95% CI) . | p Value . |
| ALM/BMI* | 288 | 0.57 (0.50, 0.69) | 1.04 (1.00, 1.08) | .033 | 1.00 (0.96, 1.05) | .884 |
| Handgrip strength (kg) | 285 | 22.82 ± 8.34 | 0.65 (0.49, 0.87) | .003 | 0.80 (0.59, 1.10) | .173 |
| Total SPPB (points) | 283 | 6.99 ± 2.84 | 0.94 (0.91, 0.96) | <.001 | 0.95 (0.92, 0.98) | .002 |
| SPPB—gait speed (m/s) | 280 | 0.74 ± 0.29 | 1.00 (0.99, 1.01) | .927 | 0.99 (0.98, 1.01) | .381 |
| SPPB—balance (points) | 282 | 4 (2, 4) | 0.87 (0.81, 0.93) | <.001 | 0.92 (0.86, 0.99) | .035 |
| SPPB—sit-to-stand (s)* | 177 | 16.62 (14.12, 21.30) | 1.03 (1.00, 1.05) | .030 | 1.02 (1.00, 1.05) | .080 |
| SPPB—sit-to-stand | 282 | |||||
| Unable | 102 (36.2%) | Reference | Reference | |||
| Able | 180 (63.8%) | 0.75 (0.63, 0.89) | .001 | 0.80 (0.67, 0.95) | .013 | |
| TUG (s)* | 267 | 15.77 (11.69, 21.21) | 1.04 (1.02, 1.06) | <.001 | 1.03 (1.00, 1.05) | .016 |
Notes: Multivariable linear regression adjusted for age, sex, smoking, malnutrition status, CCI, GDS, eGFR, and PTH levels. β-Coefficients with 95% CI represent the fold change in CTX when variable increases in 1 unit. In cases where variable was transformed (marked by asterisk*), the β-coefficient with 95% CI represents the fold change in CTX with 10% increase in variable. ALM = appendicular lean mass; BMI = body mass index; CCI = Charlson Comorbidity Index; CI = confidence interval; CTX = serum cross-linked C-telopeptides of type I collagen; eGFR = estimated glomerular filtration rate; GDS = Geriatric Depression Scale; IQR = interquartile range; PTH = parathyroid hormone; SD = standard deviation; SPPB = short physical performance battery; TUG = Timed Up and Go.
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