Table 1
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Results of multivariable Cox regression analysis for the overall study cohort

Hazard ratio [95% confidence interval], P value
New-onset heart failureaCardiovascular mortalitybMyocardial infarctionc
Mean LDL-C1.00 [0.91, 1.10], P = 0.9461.37 [1.20, 1.55], P < 0.0010.94 [0.83, 1.07], P = 0.368
SD of LDL-C1.03 [0.85, 1.25], P = 0.7450.94 [0.72, 1.24], P = 0.6771.46 [1.15, 1.85], P = 0.002
CV of LDL-C0.63 [0.36, 1.11], P = 0.1090.19 [0.08, 0.42], P < 0.0013.64 [1.81, 7.33], P < 0.001
Mean HDL-C0.60 [0.50, 0.72], P < 0.0010.54 [0.41, 0.71], P < 0.0010.46 [0.36, 0.60], P < 0.001
SD of HDL-C4.40 [2.72, 7.13], P < 0.0011.05 [0.46, 2.39], P = 0.9012.82 [1.42, 5.59], P = 0.003
CV of HDL-C48.68 [21.37, 110.90], P < 0.0011.63 [0.45, 5.97], P = 0.46039.87 [13.77, 115.47], P < 0.001
Mean total cholesterol0.89 [0.82, 0.96], P = 0.0041.21 [1.08, 1.36], P = 0.0010.87 [0.78, 0.98], P = 0.017
SD of total cholesterol1.38 [1.18, 1.62], P < 0.0011.18 [0.93, 1.51], P = 0.1691.69 [1.39, 2.06], P < 0.001
CV of total cholesterol5.49 [2.29, 13.15], P < 0.0010.58 [0.16, 2.11], P = 0.40629.94 [9.83, 91.19], P < 0.001
Hazard ratio [95% confidence interval], P value
New-onset heart failureaCardiovascular mortalitybMyocardial infarctionc
Mean LDL-C1.00 [0.91, 1.10], P = 0.9461.37 [1.20, 1.55], P < 0.0010.94 [0.83, 1.07], P = 0.368
SD of LDL-C1.03 [0.85, 1.25], P = 0.7450.94 [0.72, 1.24], P = 0.6771.46 [1.15, 1.85], P = 0.002
CV of LDL-C0.63 [0.36, 1.11], P = 0.1090.19 [0.08, 0.42], P < 0.0013.64 [1.81, 7.33], P < 0.001
Mean HDL-C0.60 [0.50, 0.72], P < 0.0010.54 [0.41, 0.71], P < 0.0010.46 [0.36, 0.60], P < 0.001
SD of HDL-C4.40 [2.72, 7.13], P < 0.0011.05 [0.46, 2.39], P = 0.9012.82 [1.42, 5.59], P = 0.003
CV of HDL-C48.68 [21.37, 110.90], P < 0.0011.63 [0.45, 5.97], P = 0.46039.87 [13.77, 115.47], P < 0.001
Mean total cholesterol0.89 [0.82, 0.96], P = 0.0041.21 [1.08, 1.36], P = 0.0010.87 [0.78, 0.98], P = 0.017
SD of total cholesterol1.38 [1.18, 1.62], P < 0.0011.18 [0.93, 1.51], P = 0.1691.69 [1.39, 2.06], P < 0.001
CV of total cholesterol5.49 [2.29, 13.15], P < 0.0010.58 [0.16, 2.11], P = 0.40629.94 [9.83, 91.19], P < 0.001

CV, coefficient of variation; SD, standard deviation.

a

Adjusted for age, hypertension, diabetes mellitus, atrial fibrillation, chronic obstructive pulmonary disease, ischaemic heart disease, peripheral vascular disease, stroke or transient ischaemic attack, dementia or Alzheimer’s disease, and use of lipid-lowering medication(s).

b

Adjusted for age, sex, hypertension, diabetes mellitus, atrial fibrillation, ischaemic heart disease, peripheral vascular disease, stroke or transient ischaemic attack, dementia or Alzheimer’s disease, and use of lipid-lowering medication(s).

c

Adjusted for age, sex, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, ischaemic heart disease, peripheral vascular disease, stroke or transient ischaemic attack, and use of lipid-lowering medication(s).

Table 1
Open in new tab

Results of multivariable Cox regression analysis for the overall study cohort

Hazard ratio [95% confidence interval], P value
New-onset heart failureaCardiovascular mortalitybMyocardial infarctionc
Mean LDL-C1.00 [0.91, 1.10], P = 0.9461.37 [1.20, 1.55], P < 0.0010.94 [0.83, 1.07], P = 0.368
SD of LDL-C1.03 [0.85, 1.25], P = 0.7450.94 [0.72, 1.24], P = 0.6771.46 [1.15, 1.85], P = 0.002
CV of LDL-C0.63 [0.36, 1.11], P = 0.1090.19 [0.08, 0.42], P < 0.0013.64 [1.81, 7.33], P < 0.001
Mean HDL-C0.60 [0.50, 0.72], P < 0.0010.54 [0.41, 0.71], P < 0.0010.46 [0.36, 0.60], P < 0.001
SD of HDL-C4.40 [2.72, 7.13], P < 0.0011.05 [0.46, 2.39], P = 0.9012.82 [1.42, 5.59], P = 0.003
CV of HDL-C48.68 [21.37, 110.90], P < 0.0011.63 [0.45, 5.97], P = 0.46039.87 [13.77, 115.47], P < 0.001
Mean total cholesterol0.89 [0.82, 0.96], P = 0.0041.21 [1.08, 1.36], P = 0.0010.87 [0.78, 0.98], P = 0.017
SD of total cholesterol1.38 [1.18, 1.62], P < 0.0011.18 [0.93, 1.51], P = 0.1691.69 [1.39, 2.06], P < 0.001
CV of total cholesterol5.49 [2.29, 13.15], P < 0.0010.58 [0.16, 2.11], P = 0.40629.94 [9.83, 91.19], P < 0.001
Hazard ratio [95% confidence interval], P value
New-onset heart failureaCardiovascular mortalitybMyocardial infarctionc
Mean LDL-C1.00 [0.91, 1.10], P = 0.9461.37 [1.20, 1.55], P < 0.0010.94 [0.83, 1.07], P = 0.368
SD of LDL-C1.03 [0.85, 1.25], P = 0.7450.94 [0.72, 1.24], P = 0.6771.46 [1.15, 1.85], P = 0.002
CV of LDL-C0.63 [0.36, 1.11], P = 0.1090.19 [0.08, 0.42], P < 0.0013.64 [1.81, 7.33], P < 0.001
Mean HDL-C0.60 [0.50, 0.72], P < 0.0010.54 [0.41, 0.71], P < 0.0010.46 [0.36, 0.60], P < 0.001
SD of HDL-C4.40 [2.72, 7.13], P < 0.0011.05 [0.46, 2.39], P = 0.9012.82 [1.42, 5.59], P = 0.003
CV of HDL-C48.68 [21.37, 110.90], P < 0.0011.63 [0.45, 5.97], P = 0.46039.87 [13.77, 115.47], P < 0.001
Mean total cholesterol0.89 [0.82, 0.96], P = 0.0041.21 [1.08, 1.36], P = 0.0010.87 [0.78, 0.98], P = 0.017
SD of total cholesterol1.38 [1.18, 1.62], P < 0.0011.18 [0.93, 1.51], P = 0.1691.69 [1.39, 2.06], P < 0.001
CV of total cholesterol5.49 [2.29, 13.15], P < 0.0010.58 [0.16, 2.11], P = 0.40629.94 [9.83, 91.19], P < 0.001

CV, coefficient of variation; SD, standard deviation.

a

Adjusted for age, hypertension, diabetes mellitus, atrial fibrillation, chronic obstructive pulmonary disease, ischaemic heart disease, peripheral vascular disease, stroke or transient ischaemic attack, dementia or Alzheimer’s disease, and use of lipid-lowering medication(s).

b

Adjusted for age, sex, hypertension, diabetes mellitus, atrial fibrillation, ischaemic heart disease, peripheral vascular disease, stroke or transient ischaemic attack, dementia or Alzheimer’s disease, and use of lipid-lowering medication(s).

c

Adjusted for age, sex, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, ischaemic heart disease, peripheral vascular disease, stroke or transient ischaemic attack, and use of lipid-lowering medication(s).

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