Table 2.
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Differential Diagnosis for Pathologic Nipple Dischargea

Differential DiagnosisIncidence of Pathologic Nipple Discharge Cases
Papilloma35%–70%
Duct ectasia17%–36%
Carcinoma (DCIS > invasive)5%–21%, age dependent
Nipple adenoma<1%
Paget disease of the nipple<1%
Ductal hyperplasia +/- atypia<10%
Fibrocystic changes<10%
Differential DiagnosisIncidence of Pathologic Nipple Discharge Cases
Papilloma35%–70%
Duct ectasia17%–36%
Carcinoma (DCIS > invasive)5%–21%, age dependent
Nipple adenoma<1%
Paget disease of the nipple<1%
Ductal hyperplasia +/- atypia<10%
Fibrocystic changes<10%

Abbreviation: DCIS, ductal carcinoma in-situ.

aAdapted from (3, 12, 15).

Table 2.
Open in new tab

Differential Diagnosis for Pathologic Nipple Dischargea

Differential DiagnosisIncidence of Pathologic Nipple Discharge Cases
Papilloma35%–70%
Duct ectasia17%–36%
Carcinoma (DCIS > invasive)5%–21%, age dependent
Nipple adenoma<1%
Paget disease of the nipple<1%
Ductal hyperplasia +/- atypia<10%
Fibrocystic changes<10%
Differential DiagnosisIncidence of Pathologic Nipple Discharge Cases
Papilloma35%–70%
Duct ectasia17%–36%
Carcinoma (DCIS > invasive)5%–21%, age dependent
Nipple adenoma<1%
Paget disease of the nipple<1%
Ductal hyperplasia +/- atypia<10%
Fibrocystic changes<10%

Abbreviation: DCIS, ductal carcinoma in-situ.

aAdapted from (3, 12, 15).

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