Table 1.
Open in new tab

Summary of the effect of parameter changes on equilibrium cell counts.

Increased parameterNiche-bound NHInactive IHActive AHProgenitors iDH
Niche capacity, K↑↑↑↑
Detachment from niche, u0↑↑↑
Division rate, r↑↑*↑
Differentiation of active, dA↓↓↓↓
Differentiation of inactive, dI↓↓↓↓
Attachment to the niche, b↑↑↑↑
Increased parameterNiche-bound NHInactive IHActive AHProgenitors iDH
Niche capacity, K↑↑↑↑
Detachment from niche, u0↑↑↑
Division rate, r↑↑*↑
Differentiation of active, dA↓↓↓↓
Differentiation of inactive, dI↓↓↓↓
Attachment to the niche, b↑↑↑↑

↑ indicates that the value of the respective variable increases if the value of the respective parameter is increased, ↓ indicates that the value of the respective variable decreases if the value of the respective parameter is increased. *Increasing only if division rate of active stem cells, r, is close to the differentiation rate of active stem cells, dA, otherwise decreasing, see Supplementary Fig. S8.

Table 1.
Open in new tab

Summary of the effect of parameter changes on equilibrium cell counts.

Increased parameterNiche-bound NHInactive IHActive AHProgenitors iDH
Niche capacity, K↑↑↑↑
Detachment from niche, u0↑↑↑
Division rate, r↑↑*↑
Differentiation of active, dA↓↓↓↓
Differentiation of inactive, dI↓↓↓↓
Attachment to the niche, b↑↑↑↑
Increased parameterNiche-bound NHInactive IHActive AHProgenitors iDH
Niche capacity, K↑↑↑↑
Detachment from niche, u0↑↑↑
Division rate, r↑↑*↑
Differentiation of active, dA↓↓↓↓
Differentiation of inactive, dI↓↓↓↓
Attachment to the niche, b↑↑↑↑

↑ indicates that the value of the respective variable increases if the value of the respective parameter is increased, ↓ indicates that the value of the respective variable decreases if the value of the respective parameter is increased. *Increasing only if division rate of active stem cells, r, is close to the differentiation rate of active stem cells, dA, otherwise decreasing, see Supplementary Fig. S8.

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