Validated indices for assessment of histological disease activity in ulcerative colitis.
| Robarts Histopathology Index (RHI) . | Nancy Index . |
|---|---|
| Chronic inflammatory infiltrate (Multiply the score by 1) 0 = No increase 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Lamina propria neutrophils (multiply the score by 2) 0 = None 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Neutrophils in epithelium (Multiply the score by 3) 0 = None 1=<5% crypts involved 2=<50% crypts involved 3=>50% crypts involved Erosion or ulceration (multiply the score by 5) 0 = No erosion, ulceration or granulation tissue 1 = Recovering epithelium + adjacent inflammation 1 = Probable erosion—focally stripped 2 = Unequivocal erosion 3 = Ulcer or granulation tissue | Grade 0 No or mild increase in chronic inflammatory cells Grade 1 No acute inflammatory cell infiltrate and presence of a moderate-to-severe increase in chronic inflammatory cells Grade 2 Few or rare neutrophils in lamina propria or in the epithelium that are difficult to see Grade 3 Presence of multiple clusters of neutrophils in lamina propria and/or in epithelium that are easily apparent (moderate to severe) Grade 4 Presence of ulcers |
| The total score of RHI ranges from 0-33. RHI ≤ 3 defines histologic remission. | Nancy index 0 defines histologic remission. |
| Robarts Histopathology Index (RHI) . | Nancy Index . |
|---|---|
| Chronic inflammatory infiltrate (Multiply the score by 1) 0 = No increase 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Lamina propria neutrophils (multiply the score by 2) 0 = None 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Neutrophils in epithelium (Multiply the score by 3) 0 = None 1=<5% crypts involved 2=<50% crypts involved 3=>50% crypts involved Erosion or ulceration (multiply the score by 5) 0 = No erosion, ulceration or granulation tissue 1 = Recovering epithelium + adjacent inflammation 1 = Probable erosion—focally stripped 2 = Unequivocal erosion 3 = Ulcer or granulation tissue | Grade 0 No or mild increase in chronic inflammatory cells Grade 1 No acute inflammatory cell infiltrate and presence of a moderate-to-severe increase in chronic inflammatory cells Grade 2 Few or rare neutrophils in lamina propria or in the epithelium that are difficult to see Grade 3 Presence of multiple clusters of neutrophils in lamina propria and/or in epithelium that are easily apparent (moderate to severe) Grade 4 Presence of ulcers |
| The total score of RHI ranges from 0-33. RHI ≤ 3 defines histologic remission. | Nancy index 0 defines histologic remission. |
Validated indices for assessment of histological disease activity in ulcerative colitis.
| Robarts Histopathology Index (RHI) . | Nancy Index . |
|---|---|
| Chronic inflammatory infiltrate (Multiply the score by 1) 0 = No increase 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Lamina propria neutrophils (multiply the score by 2) 0 = None 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Neutrophils in epithelium (Multiply the score by 3) 0 = None 1=<5% crypts involved 2=<50% crypts involved 3=>50% crypts involved Erosion or ulceration (multiply the score by 5) 0 = No erosion, ulceration or granulation tissue 1 = Recovering epithelium + adjacent inflammation 1 = Probable erosion—focally stripped 2 = Unequivocal erosion 3 = Ulcer or granulation tissue | Grade 0 No or mild increase in chronic inflammatory cells Grade 1 No acute inflammatory cell infiltrate and presence of a moderate-to-severe increase in chronic inflammatory cells Grade 2 Few or rare neutrophils in lamina propria or in the epithelium that are difficult to see Grade 3 Presence of multiple clusters of neutrophils in lamina propria and/or in epithelium that are easily apparent (moderate to severe) Grade 4 Presence of ulcers |
| The total score of RHI ranges from 0-33. RHI ≤ 3 defines histologic remission. | Nancy index 0 defines histologic remission. |
| Robarts Histopathology Index (RHI) . | Nancy Index . |
|---|---|
| Chronic inflammatory infiltrate (Multiply the score by 1) 0 = No increase 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Lamina propria neutrophils (multiply the score by 2) 0 = None 1 = Mild but unequivocal increase 2 = Moderate increase 3 = Marked increase Neutrophils in epithelium (Multiply the score by 3) 0 = None 1=<5% crypts involved 2=<50% crypts involved 3=>50% crypts involved Erosion or ulceration (multiply the score by 5) 0 = No erosion, ulceration or granulation tissue 1 = Recovering epithelium + adjacent inflammation 1 = Probable erosion—focally stripped 2 = Unequivocal erosion 3 = Ulcer or granulation tissue | Grade 0 No or mild increase in chronic inflammatory cells Grade 1 No acute inflammatory cell infiltrate and presence of a moderate-to-severe increase in chronic inflammatory cells Grade 2 Few or rare neutrophils in lamina propria or in the epithelium that are difficult to see Grade 3 Presence of multiple clusters of neutrophils in lamina propria and/or in epithelium that are easily apparent (moderate to severe) Grade 4 Presence of ulcers |
| The total score of RHI ranges from 0-33. RHI ≤ 3 defines histologic remission. | Nancy index 0 defines histologic remission. |
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