Table 2

Baseline clinical characteristics of the cohorts from enrolled studies

Author, yearAgeMaleIschaemic aetiologyNYHA III-IVAtrial fibrillationDiabetesQRS durationLVEF (%)ACE inhibitor or ARBBeta-blockerMRAdiuretics
CRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-PCRT-DCRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)
Auricchio, 20073164.0 ± 10.064.0 ± 9.066.083.027.055.095.093.018.017.025.0 ± 7.025.0 ± 7.0
Gold, 20153263.6 ± 10.662.7 ± 10.771.679.445.958.616.222.9157.0 ± 20.0152.0 ± 21.030.0 ± 6.526.1 ± 7.098.695.991.996.5
Moriani, 20133474.0 ± 9.067.0 ± 9.068.085.041.062.080.075.031.030.0175.0 + 29.0165.0 + 32.027.0 ± 5.027.0 ± 5.079.088.070.075.0212970.076.0
Kutyifa, 20141466.3 ± 10.563.9 ± 10.971.084.034.051.028.022.035.031.0165.5 ± 27.8158.2 ± 27.128.2 ± 7.427.6 ± 6.484.086.084.088.0536175.077.0
Looi, 20141770 ± 9.967 ± 9.372.691.148.365.894.187.72014.416.113.7159 ± 25.4161.0 ± 30.025.3 ± 7.723.9 ± 7.190.191.269.576.9635692.289.3
Marijon, 20153375.9 ± 9.065.6 ± 10.469.580.840.749.387.980.738.722.1160.8 + 29.0155.0 + 26.225.5 ± 10.025.5 ± 10.053.972.943.367.3153159.669.2
Reitan, 20152572.1 ± 9.765.3 ± 9.883.084.460.051.685.565.050.042.234.227.6170.0 ± 27.9164.0 ± 27.525 0.0 ± 7.025.0 ± 7.089.993.178.789.189.183.9
Munir, 20162883.0 (79.0–86.0)81.0 (78.0–83.0)63.672.829.957.329.027.7154.0 (132.0–178.0)154.0. (140.0–172.0)28.0 (23.0–33.0)23.0 (20.0–28.0)48.685.477.676.8111572.078.3
Witt, 20162075.085.537.671.584.467.843.136.426249089757855528579
Laish-Farkas, 20173784.5 ± 3.082.3 ± 2.465.086.071.087.045.038.032.044.0134.0 ± 32.4133.8 ± 30.470.074.079.077.0
Barra, 20173873.0 10.165.2 10.757.684.646.351.983.169.935.035.718.922.427.1 9.125.5 7.777.584.562.081.240.140.3
Martens, 20171675.7 ± 9.168.6 ± 10.558.677.335.752.862.458.941.532.526.426.4155.0 ± 30.0153.0 ± 29.032.9 ± 10.426.7 ± 7.880.590.175.592.6507547.551.2
Yokoshiki, 20172777.0 ± 10.266.8 ± 11.260.876.821.627.975.272.212.413.228.931.5157.9 ± 24.7153.5 ± 30.733.0 ± 11.126.5 ± 9.056.766.661.976.9304576.380.5
Drozd, 20163075.1 10.369.3 10.074.093.054.090.063.060.035.023.024.027.0156.4 ± 27.0150.0 ± 24.484.092.074.088.0
Wang, 20192681.6 ± 5.380.7 ± 3.50085.776.31926.9152.0 ± 34.8159.0 ± 24.928.0 ± 5.5024.1 ± 6.4252.487.173.878.5514
Leyva, 20182273.1 ± 1170.1 ± 970.879.743.775.391.380.936.228.020.125.4155.1 ± 21150.8 ± 2187.492.960.777.3395195.198.3
Döring 20182182.6 ± 4.577.8 ± 1.956.375.550.053.183.783.523.820.4150.0 ± 19158.0 ± 1829.6 ± 5.927.4 ± 6.086.393.880.090.7295992.586.8
Barra, 201915,4069.8 ± 10.263.8 ± 10.469.780.447.852.582.068.342.747.128.126.726.8 ± 7.625.5 ± 6.391.483.574.279.14332
Liang, 20202362.4 ± 10.459.8 ± 12.064.375.37.17.815.115.119.816.9161.28 ± 30.91157.96 ± 31.53;;91.394.584.990142191.389.5
Saba, 20192477.9 ± 8.472.6 ± 9.260.164.922.729.668.445.153.854.5
Leyva, 20191974.3 ± 11.368.1 ± 11.168.980.856.067.224.427.3
Huang, 20213660.3 ± 11.560.0 ± 12.155.374.619.828.277.684.212.710.216.913.8163.6 ± 24.9157.8 ± 27.028.1 ± 5.427.3 ± 5.282.880.7.487.387.3797783.583.7
Gras, 20201878.4 ± 967.5 ± 1064.677.457.665.568.852.131.736.9
Doran, 20213967.066.067.067.054.055.039.041.0160.0160.0­—89.090.068.068.0535594.097.0
Schrage, 20223574.3 ± 9.367.6 ± 9.878.684.273.273.464.760.567.761.591.294.093.396.9516087.084.5
Hadwiger, 20222976.7 (8.89)69.9 (9.57)52.065.073.075.085.085.059.041.032.036.0
Author, yearAgeMaleIschaemic aetiologyNYHA III-IVAtrial fibrillationDiabetesQRS durationLVEF (%)ACE inhibitor or ARBBeta-blockerMRAdiuretics
CRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-PCRT-DCRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)
Auricchio, 20073164.0 ± 10.064.0 ± 9.066.083.027.055.095.093.018.017.025.0 ± 7.025.0 ± 7.0
Gold, 20153263.6 ± 10.662.7 ± 10.771.679.445.958.616.222.9157.0 ± 20.0152.0 ± 21.030.0 ± 6.526.1 ± 7.098.695.991.996.5
Moriani, 20133474.0 ± 9.067.0 ± 9.068.085.041.062.080.075.031.030.0175.0 + 29.0165.0 + 32.027.0 ± 5.027.0 ± 5.079.088.070.075.0212970.076.0
Kutyifa, 20141466.3 ± 10.563.9 ± 10.971.084.034.051.028.022.035.031.0165.5 ± 27.8158.2 ± 27.128.2 ± 7.427.6 ± 6.484.086.084.088.0536175.077.0
Looi, 20141770 ± 9.967 ± 9.372.691.148.365.894.187.72014.416.113.7159 ± 25.4161.0 ± 30.025.3 ± 7.723.9 ± 7.190.191.269.576.9635692.289.3
Marijon, 20153375.9 ± 9.065.6 ± 10.469.580.840.749.387.980.738.722.1160.8 + 29.0155.0 + 26.225.5 ± 10.025.5 ± 10.053.972.943.367.3153159.669.2
Reitan, 20152572.1 ± 9.765.3 ± 9.883.084.460.051.685.565.050.042.234.227.6170.0 ± 27.9164.0 ± 27.525 0.0 ± 7.025.0 ± 7.089.993.178.789.189.183.9
Munir, 20162883.0 (79.0–86.0)81.0 (78.0–83.0)63.672.829.957.329.027.7154.0 (132.0–178.0)154.0. (140.0–172.0)28.0 (23.0–33.0)23.0 (20.0–28.0)48.685.477.676.8111572.078.3
Witt, 20162075.085.537.671.584.467.843.136.426249089757855528579
Laish-Farkas, 20173784.5 ± 3.082.3 ± 2.465.086.071.087.045.038.032.044.0134.0 ± 32.4133.8 ± 30.470.074.079.077.0
Barra, 20173873.0 10.165.2 10.757.684.646.351.983.169.935.035.718.922.427.1 9.125.5 7.777.584.562.081.240.140.3
Martens, 20171675.7 ± 9.168.6 ± 10.558.677.335.752.862.458.941.532.526.426.4155.0 ± 30.0153.0 ± 29.032.9 ± 10.426.7 ± 7.880.590.175.592.6507547.551.2
Yokoshiki, 20172777.0 ± 10.266.8 ± 11.260.876.821.627.975.272.212.413.228.931.5157.9 ± 24.7153.5 ± 30.733.0 ± 11.126.5 ± 9.056.766.661.976.9304576.380.5
Drozd, 20163075.1 10.369.3 10.074.093.054.090.063.060.035.023.024.027.0156.4 ± 27.0150.0 ± 24.484.092.074.088.0
Wang, 20192681.6 ± 5.380.7 ± 3.50085.776.31926.9152.0 ± 34.8159.0 ± 24.928.0 ± 5.5024.1 ± 6.4252.487.173.878.5514
Leyva, 20182273.1 ± 1170.1 ± 970.879.743.775.391.380.936.228.020.125.4155.1 ± 21150.8 ± 2187.492.960.777.3395195.198.3
Döring 20182182.6 ± 4.577.8 ± 1.956.375.550.053.183.783.523.820.4150.0 ± 19158.0 ± 1829.6 ± 5.927.4 ± 6.086.393.880.090.7295992.586.8
Barra, 201915,4069.8 ± 10.263.8 ± 10.469.780.447.852.582.068.342.747.128.126.726.8 ± 7.625.5 ± 6.391.483.574.279.14332
Liang, 20202362.4 ± 10.459.8 ± 12.064.375.37.17.815.115.119.816.9161.28 ± 30.91157.96 ± 31.53;;91.394.584.990142191.389.5
Saba, 20192477.9 ± 8.472.6 ± 9.260.164.922.729.668.445.153.854.5
Leyva, 20191974.3 ± 11.368.1 ± 11.168.980.856.067.224.427.3
Huang, 20213660.3 ± 11.560.0 ± 12.155.374.619.828.277.684.212.710.216.913.8163.6 ± 24.9157.8 ± 27.028.1 ± 5.427.3 ± 5.282.880.7.487.387.3797783.583.7
Gras, 20201878.4 ± 967.5 ± 1064.677.457.665.568.852.131.736.9
Doran, 20213967.066.067.067.054.055.039.041.0160.0160.0­—89.090.068.068.0535594.097.0
Schrage, 20223574.3 ± 9.367.6 ± 9.878.684.273.273.464.760.567.761.591.294.093.396.9516087.084.5
Hadwiger, 20222976.7 (8.89)69.9 (9.57)52.065.073.075.085.085.059.041.032.036.0
Table 2

Baseline clinical characteristics of the cohorts from enrolled studies

Author, yearAgeMaleIschaemic aetiologyNYHA III-IVAtrial fibrillationDiabetesQRS durationLVEF (%)ACE inhibitor or ARBBeta-blockerMRAdiuretics
CRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-PCRT-DCRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)
Auricchio, 20073164.0 ± 10.064.0 ± 9.066.083.027.055.095.093.018.017.025.0 ± 7.025.0 ± 7.0
Gold, 20153263.6 ± 10.662.7 ± 10.771.679.445.958.616.222.9157.0 ± 20.0152.0 ± 21.030.0 ± 6.526.1 ± 7.098.695.991.996.5
Moriani, 20133474.0 ± 9.067.0 ± 9.068.085.041.062.080.075.031.030.0175.0 + 29.0165.0 + 32.027.0 ± 5.027.0 ± 5.079.088.070.075.0212970.076.0
Kutyifa, 20141466.3 ± 10.563.9 ± 10.971.084.034.051.028.022.035.031.0165.5 ± 27.8158.2 ± 27.128.2 ± 7.427.6 ± 6.484.086.084.088.0536175.077.0
Looi, 20141770 ± 9.967 ± 9.372.691.148.365.894.187.72014.416.113.7159 ± 25.4161.0 ± 30.025.3 ± 7.723.9 ± 7.190.191.269.576.9635692.289.3
Marijon, 20153375.9 ± 9.065.6 ± 10.469.580.840.749.387.980.738.722.1160.8 + 29.0155.0 + 26.225.5 ± 10.025.5 ± 10.053.972.943.367.3153159.669.2
Reitan, 20152572.1 ± 9.765.3 ± 9.883.084.460.051.685.565.050.042.234.227.6170.0 ± 27.9164.0 ± 27.525 0.0 ± 7.025.0 ± 7.089.993.178.789.189.183.9
Munir, 20162883.0 (79.0–86.0)81.0 (78.0–83.0)63.672.829.957.329.027.7154.0 (132.0–178.0)154.0. (140.0–172.0)28.0 (23.0–33.0)23.0 (20.0–28.0)48.685.477.676.8111572.078.3
Witt, 20162075.085.537.671.584.467.843.136.426249089757855528579
Laish-Farkas, 20173784.5 ± 3.082.3 ± 2.465.086.071.087.045.038.032.044.0134.0 ± 32.4133.8 ± 30.470.074.079.077.0
Barra, 20173873.0 10.165.2 10.757.684.646.351.983.169.935.035.718.922.427.1 9.125.5 7.777.584.562.081.240.140.3
Martens, 20171675.7 ± 9.168.6 ± 10.558.677.335.752.862.458.941.532.526.426.4155.0 ± 30.0153.0 ± 29.032.9 ± 10.426.7 ± 7.880.590.175.592.6507547.551.2
Yokoshiki, 20172777.0 ± 10.266.8 ± 11.260.876.821.627.975.272.212.413.228.931.5157.9 ± 24.7153.5 ± 30.733.0 ± 11.126.5 ± 9.056.766.661.976.9304576.380.5
Drozd, 20163075.1 10.369.3 10.074.093.054.090.063.060.035.023.024.027.0156.4 ± 27.0150.0 ± 24.484.092.074.088.0
Wang, 20192681.6 ± 5.380.7 ± 3.50085.776.31926.9152.0 ± 34.8159.0 ± 24.928.0 ± 5.5024.1 ± 6.4252.487.173.878.5514
Leyva, 20182273.1 ± 1170.1 ± 970.879.743.775.391.380.936.228.020.125.4155.1 ± 21150.8 ± 2187.492.960.777.3395195.198.3
Döring 20182182.6 ± 4.577.8 ± 1.956.375.550.053.183.783.523.820.4150.0 ± 19158.0 ± 1829.6 ± 5.927.4 ± 6.086.393.880.090.7295992.586.8
Barra, 201915,4069.8 ± 10.263.8 ± 10.469.780.447.852.582.068.342.747.128.126.726.8 ± 7.625.5 ± 6.391.483.574.279.14332
Liang, 20202362.4 ± 10.459.8 ± 12.064.375.37.17.815.115.119.816.9161.28 ± 30.91157.96 ± 31.53;;91.394.584.990142191.389.5
Saba, 20192477.9 ± 8.472.6 ± 9.260.164.922.729.668.445.153.854.5
Leyva, 20191974.3 ± 11.368.1 ± 11.168.980.856.067.224.427.3
Huang, 20213660.3 ± 11.560.0 ± 12.155.374.619.828.277.684.212.710.216.913.8163.6 ± 24.9157.8 ± 27.028.1 ± 5.427.3 ± 5.282.880.7.487.387.3797783.583.7
Gras, 20201878.4 ± 967.5 ± 1064.677.457.665.568.852.131.736.9
Doran, 20213967.066.067.067.054.055.039.041.0160.0160.0­—89.090.068.068.0535594.097.0
Schrage, 20223574.3 ± 9.367.6 ± 9.878.684.273.273.464.760.567.761.591.294.093.396.9516087.084.5
Hadwiger, 20222976.7 (8.89)69.9 (9.57)52.065.073.075.085.085.059.041.032.036.0
Author, yearAgeMaleIschaemic aetiologyNYHA III-IVAtrial fibrillationDiabetesQRS durationLVEF (%)ACE inhibitor or ARBBeta-blockerMRAdiuretics
CRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-PCRT-DCRT-PCRT-DCRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)CRT-P (%)CRT-D (%)
Auricchio, 20073164.0 ± 10.064.0 ± 9.066.083.027.055.095.093.018.017.025.0 ± 7.025.0 ± 7.0
Gold, 20153263.6 ± 10.662.7 ± 10.771.679.445.958.616.222.9157.0 ± 20.0152.0 ± 21.030.0 ± 6.526.1 ± 7.098.695.991.996.5
Moriani, 20133474.0 ± 9.067.0 ± 9.068.085.041.062.080.075.031.030.0175.0 + 29.0165.0 + 32.027.0 ± 5.027.0 ± 5.079.088.070.075.0212970.076.0
Kutyifa, 20141466.3 ± 10.563.9 ± 10.971.084.034.051.028.022.035.031.0165.5 ± 27.8158.2 ± 27.128.2 ± 7.427.6 ± 6.484.086.084.088.0536175.077.0
Looi, 20141770 ± 9.967 ± 9.372.691.148.365.894.187.72014.416.113.7159 ± 25.4161.0 ± 30.025.3 ± 7.723.9 ± 7.190.191.269.576.9635692.289.3
Marijon, 20153375.9 ± 9.065.6 ± 10.469.580.840.749.387.980.738.722.1160.8 + 29.0155.0 + 26.225.5 ± 10.025.5 ± 10.053.972.943.367.3153159.669.2
Reitan, 20152572.1 ± 9.765.3 ± 9.883.084.460.051.685.565.050.042.234.227.6170.0 ± 27.9164.0 ± 27.525 0.0 ± 7.025.0 ± 7.089.993.178.789.189.183.9
Munir, 20162883.0 (79.0–86.0)81.0 (78.0–83.0)63.672.829.957.329.027.7154.0 (132.0–178.0)154.0. (140.0–172.0)28.0 (23.0–33.0)23.0 (20.0–28.0)48.685.477.676.8111572.078.3
Witt, 20162075.085.537.671.584.467.843.136.426249089757855528579
Laish-Farkas, 20173784.5 ± 3.082.3 ± 2.465.086.071.087.045.038.032.044.0134.0 ± 32.4133.8 ± 30.470.074.079.077.0
Barra, 20173873.0 10.165.2 10.757.684.646.351.983.169.935.035.718.922.427.1 9.125.5 7.777.584.562.081.240.140.3
Martens, 20171675.7 ± 9.168.6 ± 10.558.677.335.752.862.458.941.532.526.426.4155.0 ± 30.0153.0 ± 29.032.9 ± 10.426.7 ± 7.880.590.175.592.6507547.551.2
Yokoshiki, 20172777.0 ± 10.266.8 ± 11.260.876.821.627.975.272.212.413.228.931.5157.9 ± 24.7153.5 ± 30.733.0 ± 11.126.5 ± 9.056.766.661.976.9304576.380.5
Drozd, 20163075.1 10.369.3 10.074.093.054.090.063.060.035.023.024.027.0156.4 ± 27.0150.0 ± 24.484.092.074.088.0
Wang, 20192681.6 ± 5.380.7 ± 3.50085.776.31926.9152.0 ± 34.8159.0 ± 24.928.0 ± 5.5024.1 ± 6.4252.487.173.878.5514
Leyva, 20182273.1 ± 1170.1 ± 970.879.743.775.391.380.936.228.020.125.4155.1 ± 21150.8 ± 2187.492.960.777.3395195.198.3
Döring 20182182.6 ± 4.577.8 ± 1.956.375.550.053.183.783.523.820.4150.0 ± 19158.0 ± 1829.6 ± 5.927.4 ± 6.086.393.880.090.7295992.586.8
Barra, 201915,4069.8 ± 10.263.8 ± 10.469.780.447.852.582.068.342.747.128.126.726.8 ± 7.625.5 ± 6.391.483.574.279.14332
Liang, 20202362.4 ± 10.459.8 ± 12.064.375.37.17.815.115.119.816.9161.28 ± 30.91157.96 ± 31.53;;91.394.584.990142191.389.5
Saba, 20192477.9 ± 8.472.6 ± 9.260.164.922.729.668.445.153.854.5
Leyva, 20191974.3 ± 11.368.1 ± 11.168.980.856.067.224.427.3
Huang, 20213660.3 ± 11.560.0 ± 12.155.374.619.828.277.684.212.710.216.913.8163.6 ± 24.9157.8 ± 27.028.1 ± 5.427.3 ± 5.282.880.7.487.387.3797783.583.7
Gras, 20201878.4 ± 967.5 ± 1064.677.457.665.568.852.131.736.9
Doran, 20213967.066.067.067.054.055.039.041.0160.0160.0­—89.090.068.068.0535594.097.0
Schrage, 20223574.3 ± 9.367.6 ± 9.878.684.273.273.464.760.567.761.591.294.093.396.9516087.084.5
Hadwiger, 20222976.7 (8.89)69.9 (9.57)52.065.073.075.085.085.059.041.032.036.0
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