Selected factors and estimated covariate effects for the ANDI study based on five groups.
| Risk factors . | Groups . | BAR . | Group BAR . | Group LASSO . | Group ALASSO . | Group MCP . | Group SCAD . | Group SELO . | Group SICA . |
|---|---|---|---|---|---|---|---|---|---|
| Gender | 1 | - | - | - | - | - | - | - | - |
| MaritalStatus | 1 | - | - | - | - | - | - | - | - |
| Age | 2 | −0.259(0.191) | −0.343(0.085) | −0.24(0.085) | −0.295(0.115) | −0.3(0.118) | −0.3(0.117) | −0.352(0.125) | −0.352(0.124) |
| PTEDUCAT | 3 | - | -0.025(0.056) | 0.008(0.056) | −0.005(0.087) | - | - | −0.031(0.108) | −0.031(0.107) |
| MMSE | 3 | - | −0.149(0.07) | −0.071(0.07) | −0.091(0.115) | - | - | -0.159(0.142) | −0.16(0.145) |
| APOEε4 | 2 | 0.245(0.162) | 0.262(0.083) | 0.223(0.083) | 0.252(0.098) | 0.277(0.102) | 0.277(0.101) | 0.262(0.107) | 0.262(0.106) |
| ADAS11 | 4 | - | - | 0.068(0.065) | 0.046(0.279) | - | - | - | - |
| ADAS13 | 4 | 0.208(0.201) | - | 0.086(0.059) | 0.097(0.4) | - | - | - | - |
| ADASQ4 | 4 | - | - | 0.054(0.053) | 0.042(0.144) | - | - | - | - |
| RAVLT.i | 5 | −0.603(0.184) | −0.6(0.109) | −0.444(0.109) | −0.526(0.15) | −0.619(0.232) | −0.619(0.206) | −0.602(0.174) | −0.602(0.17) |
| RAVLT.l | 5 | - | 0.234(0.087) | 0.113(0.087) | 0.206(0.134) | 0.206(0.133) | 0.207(0.13) | 0.254(0.151) | 0.255(0.153) |
| RAVLT.f | 5 | - | −0.199(0.076) | −0.106(0.076) | −0.172(0.16) | −0.201(0.196) | −0.201(0.201) | −0.221(0.228) | −0.223(0.229) |
| RAVLT.perc.f | 5 | - | 0.302(0.097) | 0.201(0.097) | 0.267(0.199) | 0.32(0.238) | 0.32(0.238) | 0.32(0.274) | 0.321(0.273) |
| DIGITSCOR | 3 | - | −0.128(0.068) | −0.064(0.068) | −0.067(0.126) | - | - | −0.142(0.165) | −0.143(0.163) |
| TRABSCOR | 3 | - | 0.005(0.057) | 0.039(0.057) | 0.02(0.099) | - | - | −0.008(0.121) | −0.009(0.121) |
| CDRSB | 3 | - | 0.077(0.055) | 0.058(0.055) | 0.061(0.101) | - | - | 0.078(0.135) | 0.078(0.133) |
| FAQ | 2 | 0.298(0.158) | 0.251(0.093) | 0.237(0.093) | 0.25(0.122) | 0.331(0.101) | 0.331(0.105) | 0.25(0.135) | 0.25(0.136) |
| Hippocampus | 3 | - | −0.193(0.067) | −0.065(0.067) | −0.088(0.134) | - | - | −0.224(0.185) | −0.227(0.185) |
| Entorhinal | 2 | −0.268(0.235) | −0.275(0.123) | −0.226(0.123) | −0.252(0.179) | −0.352(0.175) | −0.352(0.179) | −0.267(0.202) | −0.266(0.201) |
| Fusiform | 3 | - | −0.018(0.076) | −0.035(0.076) | −0.031(0.156) | - | - | −0.018(0.198) | −0.018(0.197) |
| MidTemp | 2 | −0.625(0.343) | −0.537(0.127) | −0.433(0.127) | −0.515(0.182) | −0.652(0.158) | −0.652(0.164) | −0.544(0.215) | −0.544(0.21) |
| WholeBrain | 3 | - | 0.014(0.044) | −0.001(0.044) | −0.006(0.153) | - | - | 0.024(0.306) | 0.025(0.304) |
| Ventricles | 3 | - | −0.00007(0.051) | 0.04(0.051) | 0.031(0.103) | - | - | −0.009(0.149) | −0.009(0.15) |
| ICV | 2 | 0.308(0.234) | 0.32(0.092) | 0.199(0.092) | 0.278(0.172) | 0.326(0.126) | 0.326(0.134) | 0.331(0.277) | 0.331(0.275) |
| Risk factors . | Groups . | BAR . | Group BAR . | Group LASSO . | Group ALASSO . | Group MCP . | Group SCAD . | Group SELO . | Group SICA . |
|---|---|---|---|---|---|---|---|---|---|
| Gender | 1 | - | - | - | - | - | - | - | - |
| MaritalStatus | 1 | - | - | - | - | - | - | - | - |
| Age | 2 | −0.259(0.191) | −0.343(0.085) | −0.24(0.085) | −0.295(0.115) | −0.3(0.118) | −0.3(0.117) | −0.352(0.125) | −0.352(0.124) |
| PTEDUCAT | 3 | - | -0.025(0.056) | 0.008(0.056) | −0.005(0.087) | - | - | −0.031(0.108) | −0.031(0.107) |
| MMSE | 3 | - | −0.149(0.07) | −0.071(0.07) | −0.091(0.115) | - | - | -0.159(0.142) | −0.16(0.145) |
| APOEε4 | 2 | 0.245(0.162) | 0.262(0.083) | 0.223(0.083) | 0.252(0.098) | 0.277(0.102) | 0.277(0.101) | 0.262(0.107) | 0.262(0.106) |
| ADAS11 | 4 | - | - | 0.068(0.065) | 0.046(0.279) | - | - | - | - |
| ADAS13 | 4 | 0.208(0.201) | - | 0.086(0.059) | 0.097(0.4) | - | - | - | - |
| ADASQ4 | 4 | - | - | 0.054(0.053) | 0.042(0.144) | - | - | - | - |
| RAVLT.i | 5 | −0.603(0.184) | −0.6(0.109) | −0.444(0.109) | −0.526(0.15) | −0.619(0.232) | −0.619(0.206) | −0.602(0.174) | −0.602(0.17) |
| RAVLT.l | 5 | - | 0.234(0.087) | 0.113(0.087) | 0.206(0.134) | 0.206(0.133) | 0.207(0.13) | 0.254(0.151) | 0.255(0.153) |
| RAVLT.f | 5 | - | −0.199(0.076) | −0.106(0.076) | −0.172(0.16) | −0.201(0.196) | −0.201(0.201) | −0.221(0.228) | −0.223(0.229) |
| RAVLT.perc.f | 5 | - | 0.302(0.097) | 0.201(0.097) | 0.267(0.199) | 0.32(0.238) | 0.32(0.238) | 0.32(0.274) | 0.321(0.273) |
| DIGITSCOR | 3 | - | −0.128(0.068) | −0.064(0.068) | −0.067(0.126) | - | - | −0.142(0.165) | −0.143(0.163) |
| TRABSCOR | 3 | - | 0.005(0.057) | 0.039(0.057) | 0.02(0.099) | - | - | −0.008(0.121) | −0.009(0.121) |
| CDRSB | 3 | - | 0.077(0.055) | 0.058(0.055) | 0.061(0.101) | - | - | 0.078(0.135) | 0.078(0.133) |
| FAQ | 2 | 0.298(0.158) | 0.251(0.093) | 0.237(0.093) | 0.25(0.122) | 0.331(0.101) | 0.331(0.105) | 0.25(0.135) | 0.25(0.136) |
| Hippocampus | 3 | - | −0.193(0.067) | −0.065(0.067) | −0.088(0.134) | - | - | −0.224(0.185) | −0.227(0.185) |
| Entorhinal | 2 | −0.268(0.235) | −0.275(0.123) | −0.226(0.123) | −0.252(0.179) | −0.352(0.175) | −0.352(0.179) | −0.267(0.202) | −0.266(0.201) |
| Fusiform | 3 | - | −0.018(0.076) | −0.035(0.076) | −0.031(0.156) | - | - | −0.018(0.198) | −0.018(0.197) |
| MidTemp | 2 | −0.625(0.343) | −0.537(0.127) | −0.433(0.127) | −0.515(0.182) | −0.652(0.158) | −0.652(0.164) | −0.544(0.215) | −0.544(0.21) |
| WholeBrain | 3 | - | 0.014(0.044) | −0.001(0.044) | −0.006(0.153) | - | - | 0.024(0.306) | 0.025(0.304) |
| Ventricles | 3 | - | −0.00007(0.051) | 0.04(0.051) | 0.031(0.103) | - | - | −0.009(0.149) | −0.009(0.15) |
| ICV | 2 | 0.308(0.234) | 0.32(0.092) | 0.199(0.092) | 0.278(0.172) | 0.326(0.126) | 0.326(0.134) | 0.331(0.277) | 0.331(0.275) |
Selected factors and estimated covariate effects for the ANDI study based on five groups.
| Risk factors . | Groups . | BAR . | Group BAR . | Group LASSO . | Group ALASSO . | Group MCP . | Group SCAD . | Group SELO . | Group SICA . |
|---|---|---|---|---|---|---|---|---|---|
| Gender | 1 | - | - | - | - | - | - | - | - |
| MaritalStatus | 1 | - | - | - | - | - | - | - | - |
| Age | 2 | −0.259(0.191) | −0.343(0.085) | −0.24(0.085) | −0.295(0.115) | −0.3(0.118) | −0.3(0.117) | −0.352(0.125) | −0.352(0.124) |
| PTEDUCAT | 3 | - | -0.025(0.056) | 0.008(0.056) | −0.005(0.087) | - | - | −0.031(0.108) | −0.031(0.107) |
| MMSE | 3 | - | −0.149(0.07) | −0.071(0.07) | −0.091(0.115) | - | - | -0.159(0.142) | −0.16(0.145) |
| APOEε4 | 2 | 0.245(0.162) | 0.262(0.083) | 0.223(0.083) | 0.252(0.098) | 0.277(0.102) | 0.277(0.101) | 0.262(0.107) | 0.262(0.106) |
| ADAS11 | 4 | - | - | 0.068(0.065) | 0.046(0.279) | - | - | - | - |
| ADAS13 | 4 | 0.208(0.201) | - | 0.086(0.059) | 0.097(0.4) | - | - | - | - |
| ADASQ4 | 4 | - | - | 0.054(0.053) | 0.042(0.144) | - | - | - | - |
| RAVLT.i | 5 | −0.603(0.184) | −0.6(0.109) | −0.444(0.109) | −0.526(0.15) | −0.619(0.232) | −0.619(0.206) | −0.602(0.174) | −0.602(0.17) |
| RAVLT.l | 5 | - | 0.234(0.087) | 0.113(0.087) | 0.206(0.134) | 0.206(0.133) | 0.207(0.13) | 0.254(0.151) | 0.255(0.153) |
| RAVLT.f | 5 | - | −0.199(0.076) | −0.106(0.076) | −0.172(0.16) | −0.201(0.196) | −0.201(0.201) | −0.221(0.228) | −0.223(0.229) |
| RAVLT.perc.f | 5 | - | 0.302(0.097) | 0.201(0.097) | 0.267(0.199) | 0.32(0.238) | 0.32(0.238) | 0.32(0.274) | 0.321(0.273) |
| DIGITSCOR | 3 | - | −0.128(0.068) | −0.064(0.068) | −0.067(0.126) | - | - | −0.142(0.165) | −0.143(0.163) |
| TRABSCOR | 3 | - | 0.005(0.057) | 0.039(0.057) | 0.02(0.099) | - | - | −0.008(0.121) | −0.009(0.121) |
| CDRSB | 3 | - | 0.077(0.055) | 0.058(0.055) | 0.061(0.101) | - | - | 0.078(0.135) | 0.078(0.133) |
| FAQ | 2 | 0.298(0.158) | 0.251(0.093) | 0.237(0.093) | 0.25(0.122) | 0.331(0.101) | 0.331(0.105) | 0.25(0.135) | 0.25(0.136) |
| Hippocampus | 3 | - | −0.193(0.067) | −0.065(0.067) | −0.088(0.134) | - | - | −0.224(0.185) | −0.227(0.185) |
| Entorhinal | 2 | −0.268(0.235) | −0.275(0.123) | −0.226(0.123) | −0.252(0.179) | −0.352(0.175) | −0.352(0.179) | −0.267(0.202) | −0.266(0.201) |
| Fusiform | 3 | - | −0.018(0.076) | −0.035(0.076) | −0.031(0.156) | - | - | −0.018(0.198) | −0.018(0.197) |
| MidTemp | 2 | −0.625(0.343) | −0.537(0.127) | −0.433(0.127) | −0.515(0.182) | −0.652(0.158) | −0.652(0.164) | −0.544(0.215) | −0.544(0.21) |
| WholeBrain | 3 | - | 0.014(0.044) | −0.001(0.044) | −0.006(0.153) | - | - | 0.024(0.306) | 0.025(0.304) |
| Ventricles | 3 | - | −0.00007(0.051) | 0.04(0.051) | 0.031(0.103) | - | - | −0.009(0.149) | −0.009(0.15) |
| ICV | 2 | 0.308(0.234) | 0.32(0.092) | 0.199(0.092) | 0.278(0.172) | 0.326(0.126) | 0.326(0.134) | 0.331(0.277) | 0.331(0.275) |
| Risk factors . | Groups . | BAR . | Group BAR . | Group LASSO . | Group ALASSO . | Group MCP . | Group SCAD . | Group SELO . | Group SICA . |
|---|---|---|---|---|---|---|---|---|---|
| Gender | 1 | - | - | - | - | - | - | - | - |
| MaritalStatus | 1 | - | - | - | - | - | - | - | - |
| Age | 2 | −0.259(0.191) | −0.343(0.085) | −0.24(0.085) | −0.295(0.115) | −0.3(0.118) | −0.3(0.117) | −0.352(0.125) | −0.352(0.124) |
| PTEDUCAT | 3 | - | -0.025(0.056) | 0.008(0.056) | −0.005(0.087) | - | - | −0.031(0.108) | −0.031(0.107) |
| MMSE | 3 | - | −0.149(0.07) | −0.071(0.07) | −0.091(0.115) | - | - | -0.159(0.142) | −0.16(0.145) |
| APOEε4 | 2 | 0.245(0.162) | 0.262(0.083) | 0.223(0.083) | 0.252(0.098) | 0.277(0.102) | 0.277(0.101) | 0.262(0.107) | 0.262(0.106) |
| ADAS11 | 4 | - | - | 0.068(0.065) | 0.046(0.279) | - | - | - | - |
| ADAS13 | 4 | 0.208(0.201) | - | 0.086(0.059) | 0.097(0.4) | - | - | - | - |
| ADASQ4 | 4 | - | - | 0.054(0.053) | 0.042(0.144) | - | - | - | - |
| RAVLT.i | 5 | −0.603(0.184) | −0.6(0.109) | −0.444(0.109) | −0.526(0.15) | −0.619(0.232) | −0.619(0.206) | −0.602(0.174) | −0.602(0.17) |
| RAVLT.l | 5 | - | 0.234(0.087) | 0.113(0.087) | 0.206(0.134) | 0.206(0.133) | 0.207(0.13) | 0.254(0.151) | 0.255(0.153) |
| RAVLT.f | 5 | - | −0.199(0.076) | −0.106(0.076) | −0.172(0.16) | −0.201(0.196) | −0.201(0.201) | −0.221(0.228) | −0.223(0.229) |
| RAVLT.perc.f | 5 | - | 0.302(0.097) | 0.201(0.097) | 0.267(0.199) | 0.32(0.238) | 0.32(0.238) | 0.32(0.274) | 0.321(0.273) |
| DIGITSCOR | 3 | - | −0.128(0.068) | −0.064(0.068) | −0.067(0.126) | - | - | −0.142(0.165) | −0.143(0.163) |
| TRABSCOR | 3 | - | 0.005(0.057) | 0.039(0.057) | 0.02(0.099) | - | - | −0.008(0.121) | −0.009(0.121) |
| CDRSB | 3 | - | 0.077(0.055) | 0.058(0.055) | 0.061(0.101) | - | - | 0.078(0.135) | 0.078(0.133) |
| FAQ | 2 | 0.298(0.158) | 0.251(0.093) | 0.237(0.093) | 0.25(0.122) | 0.331(0.101) | 0.331(0.105) | 0.25(0.135) | 0.25(0.136) |
| Hippocampus | 3 | - | −0.193(0.067) | −0.065(0.067) | −0.088(0.134) | - | - | −0.224(0.185) | −0.227(0.185) |
| Entorhinal | 2 | −0.268(0.235) | −0.275(0.123) | −0.226(0.123) | −0.252(0.179) | −0.352(0.175) | −0.352(0.179) | −0.267(0.202) | −0.266(0.201) |
| Fusiform | 3 | - | −0.018(0.076) | −0.035(0.076) | −0.031(0.156) | - | - | −0.018(0.198) | −0.018(0.197) |
| MidTemp | 2 | −0.625(0.343) | −0.537(0.127) | −0.433(0.127) | −0.515(0.182) | −0.652(0.158) | −0.652(0.164) | −0.544(0.215) | −0.544(0.21) |
| WholeBrain | 3 | - | 0.014(0.044) | −0.001(0.044) | −0.006(0.153) | - | - | 0.024(0.306) | 0.025(0.304) |
| Ventricles | 3 | - | −0.00007(0.051) | 0.04(0.051) | 0.031(0.103) | - | - | −0.009(0.149) | −0.009(0.15) |
| ICV | 2 | 0.308(0.234) | 0.32(0.092) | 0.199(0.092) | 0.278(0.172) | 0.326(0.126) | 0.326(0.134) | 0.331(0.277) | 0.331(0.275) |
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