Table 1:
Open in new tab

Patient characteristics for the paediatric DAH cohort and the total ARISE Registry cohort (all DAH)

Paediatric AVR, n = 143All DAH n = 358
Implantation period2008–20232008–2023
Age at implantation (years)10.8 [6.6–14.6]23.9 [12.5–44.8]
Follow-up (years)5.3 [3.3–7.2]5.0 [3.1–6.5]
Total follow-up (years)7561748
Sex (male)106 (74%)250 (70 %)
Number of previous operations
 059200
 14790
 22446
 >21322
Type of previous procedures
 1 × aortic valve replacement1949
 2 × aortic valve replacement411
 3 × aortic valve replacement12
 Catheter-based intervention6892
 Aortic valve repair2840
Allograft diameter (mm), median [IQR]21 [19–23]23 [21–25]
 10–182628
 19–2276127
 23–2941203
Implantation time (min)
 Total operation348 [227–439]303 [244–400]
 Cardiopulmonary bypass212 [171–257]168 [132–220]
 Cross clamp135 [113–164]120 [97–146]
Latest echocardiography
 Aortic annulus (mm)20.5 (3.7)22.1 (3.8)
 Aortic annulus, z-score0.02(1.50)0.18 (1.47)
 Effective orifice area (cm2)2.36 (0.84)2.95 (0.83)
 Peak gradient (mmHg)14 [9–28]11.6 [7.8–19.4]
 Regurgitation (grade 0–3)0.5 [0–1]0.5 [0–1]
 LV ejection fraction (%)64.7 [58.5–68.5]64.0 [59.5–68.0]
Paediatric AVR, n = 143All DAH n = 358
Implantation period2008–20232008–2023
Age at implantation (years)10.8 [6.6–14.6]23.9 [12.5–44.8]
Follow-up (years)5.3 [3.3–7.2]5.0 [3.1–6.5]
Total follow-up (years)7561748
Sex (male)106 (74%)250 (70 %)
Number of previous operations
 059200
 14790
 22446
 >21322
Type of previous procedures
 1 × aortic valve replacement1949
 2 × aortic valve replacement411
 3 × aortic valve replacement12
 Catheter-based intervention6892
 Aortic valve repair2840
Allograft diameter (mm), median [IQR]21 [19–23]23 [21–25]
 10–182628
 19–2276127
 23–2941203
Implantation time (min)
 Total operation348 [227–439]303 [244–400]
 Cardiopulmonary bypass212 [171–257]168 [132–220]
 Cross clamp135 [113–164]120 [97–146]
Latest echocardiography
 Aortic annulus (mm)20.5 (3.7)22.1 (3.8)
 Aortic annulus, z-score0.02(1.50)0.18 (1.47)
 Effective orifice area (cm2)2.36 (0.84)2.95 (0.83)
 Peak gradient (mmHg)14 [9–28]11.6 [7.8–19.4]
 Regurgitation (grade 0–3)0.5 [0–1]0.5 [0–1]
 LV ejection fraction (%)64.7 [58.5–68.5]64.0 [59.5–68.0]

Mean and standard deviation are shown in round brackets for normally distributed factors, median and IQR are shown in square brackets for factors with no normal distribution.

AVR: aortic valve replacement; DAH: decellularized aortic homografts; IQR: interquartile range; LV: left ventricular.

Table 1:
Open in new tab

Patient characteristics for the paediatric DAH cohort and the total ARISE Registry cohort (all DAH)

Paediatric AVR, n = 143All DAH n = 358
Implantation period2008–20232008–2023
Age at implantation (years)10.8 [6.6–14.6]23.9 [12.5–44.8]
Follow-up (years)5.3 [3.3–7.2]5.0 [3.1–6.5]
Total follow-up (years)7561748
Sex (male)106 (74%)250 (70 %)
Number of previous operations
 059200
 14790
 22446
 >21322
Type of previous procedures
 1 × aortic valve replacement1949
 2 × aortic valve replacement411
 3 × aortic valve replacement12
 Catheter-based intervention6892
 Aortic valve repair2840
Allograft diameter (mm), median [IQR]21 [19–23]23 [21–25]
 10–182628
 19–2276127
 23–2941203
Implantation time (min)
 Total operation348 [227–439]303 [244–400]
 Cardiopulmonary bypass212 [171–257]168 [132–220]
 Cross clamp135 [113–164]120 [97–146]
Latest echocardiography
 Aortic annulus (mm)20.5 (3.7)22.1 (3.8)
 Aortic annulus, z-score0.02(1.50)0.18 (1.47)
 Effective orifice area (cm2)2.36 (0.84)2.95 (0.83)
 Peak gradient (mmHg)14 [9–28]11.6 [7.8–19.4]
 Regurgitation (grade 0–3)0.5 [0–1]0.5 [0–1]
 LV ejection fraction (%)64.7 [58.5–68.5]64.0 [59.5–68.0]
Paediatric AVR, n = 143All DAH n = 358
Implantation period2008–20232008–2023
Age at implantation (years)10.8 [6.6–14.6]23.9 [12.5–44.8]
Follow-up (years)5.3 [3.3–7.2]5.0 [3.1–6.5]
Total follow-up (years)7561748
Sex (male)106 (74%)250 (70 %)
Number of previous operations
 059200
 14790
 22446
 >21322
Type of previous procedures
 1 × aortic valve replacement1949
 2 × aortic valve replacement411
 3 × aortic valve replacement12
 Catheter-based intervention6892
 Aortic valve repair2840
Allograft diameter (mm), median [IQR]21 [19–23]23 [21–25]
 10–182628
 19–2276127
 23–2941203
Implantation time (min)
 Total operation348 [227–439]303 [244–400]
 Cardiopulmonary bypass212 [171–257]168 [132–220]
 Cross clamp135 [113–164]120 [97–146]
Latest echocardiography
 Aortic annulus (mm)20.5 (3.7)22.1 (3.8)
 Aortic annulus, z-score0.02(1.50)0.18 (1.47)
 Effective orifice area (cm2)2.36 (0.84)2.95 (0.83)
 Peak gradient (mmHg)14 [9–28]11.6 [7.8–19.4]
 Regurgitation (grade 0–3)0.5 [0–1]0.5 [0–1]
 LV ejection fraction (%)64.7 [58.5–68.5]64.0 [59.5–68.0]

Mean and standard deviation are shown in round brackets for normally distributed factors, median and IQR are shown in square brackets for factors with no normal distribution.

AVR: aortic valve replacement; DAH: decellularized aortic homografts; IQR: interquartile range; LV: left ventricular.

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