Table 1 Open in new tab Existing public...

Name

Data

Description

Ref

AbDb

Sequence Structure

Extract Fv regions from antibody structures using the SACS database, which provides a summary of antibody PDB structures.

[37]

AB-Bind

Structure

Includes 1101 mutants with experimentally determined |$\Delta \Delta $|G changes in 32 complexes.

[38]

AbDiver

Sequences

Collects data from 900M immunoglobulin sequences (81 studies) for diversity exploration via positional profiling, V-region searches and clonotype examination.

[39]

abYsis

Sequence Structure

Bioinformatic tool perform various operations, including antibody sequence management, 3D structure integration, automated antibody numbering, canonical class annotation, unusual residue identification, humanization, germline view and user input.

[36]

Cov-AbDab

Sequence

Catalogs 12 916 entries of published/patented antibodies and nanobodies that bind to coronaviruses, such as SARS-CoV2 and SARS-CoV1.

[40]

INDI

Sequence Structure

Integrates nanobody sequences, structures and the metadata associated with them from all the major data repositories in the public domain (e.g. PDB, patent and scientific publications).

[41]

NanoLAS

Sequence Structure

User-friendly nanobody information database that provides extensive and diverse data sources. It also offers intuitive 3D visualization of nanobody structures and a comparative analysis feature, making scientific research and understanding easier.

[42]

OAS

Sequence

Houses over 2 billion immune repertoires from 90 studies, including diverse immune states, organisms and individuals, with unpaired and paired antibody sequences.

[43]

PAD

Sequence

Contains around 267 722 antibody chains sourced from primary patent documents and third-party patent documents.

[44]

PLAbDab

Sequence

Contains over 150 000 paired antibody sequences and 3D structural models from patent and academic papers.

[45]

SAbDab

Structure

Houses annotated antibody structures from the PDB, offering a consistent presentation alongside experimental details, affinity data and sequence annotations.

[46]

sdAb-DB

Sequences

Compiles single-domain antibody sequences from literature, online repositories (PDB and NCBI) and user contributions.

[47]

SKEMPI

Structure

Comprises thermodynamic and kinetic changes upon mutation in solved PPI complexes in the PDB.

[48, 49]

Thera-SAbDab

Sequence Structure

Includes World Health Organization-recognized antibody and nanobody therapeutics, matching structures in SAbDab with nearly identical sequences or identical variable domain sequences.

[50]

Name

Data

Description

Ref

AbDb

Sequence Structure

Extract Fv regions from antibody structures using the SACS database, which provides a summary of antibody PDB structures.

[37]

AB-Bind

Structure

Includes 1101 mutants with experimentally determined |$\Delta \Delta $|G changes in 32 complexes.

[38]

AbDiver

Sequences

Collects data from 900M immunoglobulin sequences (81 studies) for diversity exploration via positional profiling, V-region searches and clonotype examination.

[39]

abYsis

Sequence Structure

[36]

Cov-AbDab

Sequence

Catalogs 12 916 entries of published/patented antibodies and nanobodies that bind to coronaviruses, such as SARS-CoV2 and SARS-CoV1.

[40]

INDI

Sequence Structure

Integrates nanobody sequences, structures and the metadata associated with them from all the major data repositories in the public domain (e.g. PDB, patent and scientific publications).

[41]

NanoLAS

Sequence Structure

[42]

OAS

Sequence

Houses over 2 billion immune repertoires from 90 studies, including diverse immune states, organisms and individuals, with unpaired and paired antibody sequences.

[43]

PAD

Sequence

Contains around 267 722 antibody chains sourced from primary patent documents and third-party patent documents.

[44]

PLAbDab

Sequence

Contains over 150 000 paired antibody sequences and 3D structural models from patent and academic papers.

[45]

SAbDab

Structure

Houses annotated antibody structures from the PDB, offering a consistent presentation alongside experimental details, affinity data and sequence annotations.

[46]

sdAb-DB

Sequences

Compiles single-domain antibody sequences from literature, online repositories (PDB and NCBI) and user contributions.

[47]

SKEMPI

Structure

Comprises thermodynamic and kinetic changes upon mutation in solved PPI complexes in the PDB.

[48, 49]

Thera-SAbDab

Sequence Structure

Includes World Health Organization-recognized antibody and nanobody therapeutics, matching structures in SAbDab with nearly identical sequences or identical variable domain sequences.

[50]

Table 1

Open in new tab

Existing public databases with antibody sequences, structures and properties (data from May 2024).

Name	Data	Description	Ref
AbDb	Sequence Structure	Extract Fv regions from antibody structures using the SACS database, which provides a summary of antibody PDB structures.	[37]
AB-Bind	Structure	Includes 1101 mutants with experimentally determined \|$\Delta \Delta $\|G changes in 32 complexes.	[38]
AbDiver	Sequences	Collects data from 900M immunoglobulin sequences (81 studies) for diversity exploration via positional profiling, V-region searches and clonotype examination.	[39]
abYsis	Sequence Structure	Bioinformatic tool perform various operations, including antibody sequence management, 3D structure integration, automated antibody numbering, canonical class annotation, unusual residue identification, humanization, germline view and user input.	[36]
Cov-AbDab	Sequence	Catalogs 12 916 entries of published/patented antibodies and nanobodies that bind to coronaviruses, such as SARS-CoV2 and SARS-CoV1.	[40]
INDI	Sequence Structure	Integrates nanobody sequences, structures and the metadata associated with them from all the major data repositories in the public domain (e.g. PDB, patent and scientific publications).	[41]
NanoLAS	Sequence Structure	User-friendly nanobody information database that provides extensive and diverse data sources. It also offers intuitive 3D visualization of nanobody structures and a comparative analysis feature, making scientific research and understanding easier.	[42]
OAS	Sequence	Houses over 2 billion immune repertoires from 90 studies, including diverse immune states, organisms and individuals, with unpaired and paired antibody sequences.	[43]
PAD	Sequence	Contains around 267 722 antibody chains sourced from primary patent documents and third-party patent documents.	[44]
PLAbDab	Sequence	Contains over 150 000 paired antibody sequences and 3D structural models from patent and academic papers.	[45]
SAbDab	Structure	Houses annotated antibody structures from the PDB, offering a consistent presentation alongside experimental details, affinity data and sequence annotations.	[46]
sdAb-DB	Sequences	Compiles single-domain antibody sequences from literature, online repositories (PDB and NCBI) and user contributions.	[47]
SKEMPI	Structure	Comprises thermodynamic and kinetic changes upon mutation in solved PPI complexes in the PDB.	[48, 49]
Thera-SAbDab	Sequence Structure	Includes World Health Organization-recognized antibody and nanobody therapeutics, matching structures in SAbDab with nearly identical sequences or identical variable domain sequences.	[50]

Name	Data	Description	Ref
AbDb	Sequence Structure	Extract Fv regions from antibody structures using the SACS database, which provides a summary of antibody PDB structures.	[37]
AB-Bind	Structure	Includes 1101 mutants with experimentally determined \|$\Delta \Delta $\|G changes in 32 complexes.	[38]
AbDiver	Sequences	Collects data from 900M immunoglobulin sequences (81 studies) for diversity exploration via positional profiling, V-region searches and clonotype examination.	[39]
abYsis	Sequence Structure	Bioinformatic tool perform various operations, including antibody sequence management, 3D structure integration, automated antibody numbering, canonical class annotation, unusual residue identification, humanization, germline view and user input.	[36]
Cov-AbDab	Sequence	Catalogs 12 916 entries of published/patented antibodies and nanobodies that bind to coronaviruses, such as SARS-CoV2 and SARS-CoV1.	[40]
INDI	Sequence Structure	Integrates nanobody sequences, structures and the metadata associated with them from all the major data repositories in the public domain (e.g. PDB, patent and scientific publications).	[41]
NanoLAS	Sequence Structure	User-friendly nanobody information database that provides extensive and diverse data sources. It also offers intuitive 3D visualization of nanobody structures and a comparative analysis feature, making scientific research and understanding easier.	[42]
OAS	Sequence	Houses over 2 billion immune repertoires from 90 studies, including diverse immune states, organisms and individuals, with unpaired and paired antibody sequences.	[43]
PAD	Sequence	Contains around 267 722 antibody chains sourced from primary patent documents and third-party patent documents.	[44]
PLAbDab	Sequence	Contains over 150 000 paired antibody sequences and 3D structural models from patent and academic papers.	[45]
SAbDab	Structure	Houses annotated antibody structures from the PDB, offering a consistent presentation alongside experimental details, affinity data and sequence annotations.	[46]
sdAb-DB	Sequences	Compiles single-domain antibody sequences from literature, online repositories (PDB and NCBI) and user contributions.	[47]
SKEMPI	Structure	Comprises thermodynamic and kinetic changes upon mutation in solved PPI complexes in the PDB.	[48, 49]
Thera-SAbDab	Sequence Structure	Includes World Health Organization-recognized antibody and nanobody therapeutics, matching structures in SAbDab with nearly identical sequences or identical variable domain sequences.	[50]

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