Table 2. Open in new tab Performance...

Assay

Thresholds (ng/L)

Absolute (SD) (ng/L)

Relative (%)

Sensitivity (%)

NPV (%)

Less than threshold (%)

Specificity (%)

PPV (%)

Greater than threshold (%)

Roche
hs-cTnT

99.29

99.65

30.18

35.37

21.33

69.83

0.5

99.30

99.65

30.14

35.34

21.32

69.86

99.28

99.64

29.88

35.03

21.24

70.12

1.5

99.25

99.62

29.44

34.50

21.10

70.56

99.19

99.58

29.05

34.03

20.97

70.95

2.5

99.09

99.53

29.04

34.01

20.95

70.96

98.99

99.48

29.12

34.08

20.95

70.88

92.84

98.48

70.88

82.12

47.82

29.12

0.28

92.85

98.49

70.87

82.12

47.81

29.13

0.7

92.87

98.49

70.86

82.10

47.80

29.14

1.4

92.88

98.49

70.69

81.91

47.53

29.31

2.1

92.80

98.46

70.32

81.46

46.90

29.68

2.8

92.82

98.45

69.68

80.71

45.92

30.32

3.5

92.74

98.42

68.92

79.80

44.76

31.08

Abbott
hs-cTnI

98.70

99.63

53.01

62.14

31.51

46.99

0.5

98.68

99.62

52.39

61.40

31.09

47.61

98.63

99.60

51.08

59.85

30.24

48.92

1.5

98.60

99.57

49.17

57.60

29.10

50.83

98.58

99.55

47.17

55.24

27.99

52.83

2.5

98.50

99.51

45.63

53.42

27.18

54.37

98.49

99.49

44.37

51.93

26.55

55.63

85.32

97.35

83.05

95.11

75.49

16.95

0.52

85.37

97.36

83.04

95.11

75.51

16.96

1.3

85.43

97.37

83.02

95.10

75.47

16.98

2.6

85.47

97.37

82.98

95.06

75.32

17.02

3.9

85.47

97.37

82.90

94.96

74.96

17.10

5.2

85.41

97.36

82.77

94.80

74.36

17.23

6.5

85.39

97.34

82.53

94.52

73.32

17.47

Table 2.

Open in new tab

Performance metrics as a function of the analytical variation (absolute or relative) applied.

Assay	Thresholds (ng/L)	Absolute (SD) (ng/L)	Relative (%)	Sensitivity (%)	NPV (%)	Less than threshold (%)	Specificity (%)	PPV (%)	Greater than threshold (%)
Roche hs-cTnT	5	0	0	99.29	99.65	30.18	35.37	21.33	69.83
	5	0.5	10	99.30	99.65	30.14	35.34	21.32	69.86
	5	1	20	99.28	99.64	29.88	35.03	21.24	70.12
	5	1.5	30	99.25	99.62	29.44	34.50	21.10	70.56
	5	2	40	99.19	99.58	29.05	34.03	20.97	70.95
	5	2.5	50	99.09	99.53	29.04	34.01	20.95	70.96
	5	3	60	98.99	99.48	29.12	34.08	20.95	70.88

	14	0	0	92.84	98.48	70.88	82.12	47.82	29.12
	14	0.28	2	92.85	98.49	70.87	82.12	47.81	29.13
	14	0.7	5	92.87	98.49	70.86	82.10	47.80	29.14
	14	1.4	10	92.88	98.49	70.69	81.91	47.53	29.31
	14	2.1	15	92.80	98.46	70.32	81.46	46.90	29.68
	14	2.8	20	92.82	98.45	69.68	80.71	45.92	30.32
	14	3.5	25	92.74	98.42	68.92	79.80	44.76	31.08
Abbott hs-cTnI	5	0	0	98.70	99.63	53.01	62.14	31.51	46.99
	5	0.5	10	98.68	99.62	52.39	61.40	31.09	47.61
	5	1	20	98.63	99.60	51.08	59.85	30.24	48.92
	5	1.5	30	98.60	99.57	49.17	57.60	29.10	50.83
	5	2	40	98.58	99.55	47.17	55.24	27.99	52.83
	5	2.5	50	98.50	99.51	45.63	53.42	27.18	54.37
	5	3	60	98.49	99.49	44.37	51.93	26.55	55.63

	26	0	0	85.32	97.35	83.05	95.11	75.49	16.95
	26	0.52	2	85.37	97.36	83.04	95.11	75.51	16.96
	26	1.3	5	85.43	97.37	83.02	95.10	75.47	16.98
	26	2.6	10	85.47	97.37	82.98	95.06	75.32	17.02
	26	3.9	15	85.47	97.37	82.90	94.96	74.96	17.10
	26	5.2	20	85.41	97.36	82.77	94.80	74.36	17.23
	26	6.5	25	85.39	97.34	82.53	94.52	73.32	17.47

Assay	Thresholds (ng/L)	Absolute (SD) (ng/L)	Relative (%)	Sensitivity (%)	NPV (%)	Less than threshold (%)	Specificity (%)	PPV (%)	Greater than threshold (%)
Roche hs-cTnT	5	0	0	99.29	99.65	30.18	35.37	21.33	69.83
	5	0.5	10	99.30	99.65	30.14	35.34	21.32	69.86
	5	1	20	99.28	99.64	29.88	35.03	21.24	70.12
	5	1.5	30	99.25	99.62	29.44	34.50	21.10	70.56
	5	2	40	99.19	99.58	29.05	34.03	20.97	70.95
	5	2.5	50	99.09	99.53	29.04	34.01	20.95	70.96
	5	3	60	98.99	99.48	29.12	34.08	20.95	70.88

	14	0	0	92.84	98.48	70.88	82.12	47.82	29.12
	14	0.28	2	92.85	98.49	70.87	82.12	47.81	29.13
	14	0.7	5	92.87	98.49	70.86	82.10	47.80	29.14
	14	1.4	10	92.88	98.49	70.69	81.91	47.53	29.31
	14	2.1	15	92.80	98.46	70.32	81.46	46.90	29.68
	14	2.8	20	92.82	98.45	69.68	80.71	45.92	30.32
	14	3.5	25	92.74	98.42	68.92	79.80	44.76	31.08
Abbott hs-cTnI	5	0	0	98.70	99.63	53.01	62.14	31.51	46.99
	5	0.5	10	98.68	99.62	52.39	61.40	31.09	47.61
	5	1	20	98.63	99.60	51.08	59.85	30.24	48.92
	5	1.5	30	98.60	99.57	49.17	57.60	29.10	50.83
	5	2	40	98.58	99.55	47.17	55.24	27.99	52.83
	5	2.5	50	98.50	99.51	45.63	53.42	27.18	54.37
	5	3	60	98.49	99.49	44.37	51.93	26.55	55.63

	26	0	0	85.32	97.35	83.05	95.11	75.49	16.95
	26	0.52	2	85.37	97.36	83.04	95.11	75.51	16.96
	26	1.3	5	85.43	97.37	83.02	95.10	75.47	16.98
	26	2.6	10	85.47	97.37	82.98	95.06	75.32	17.02
	26	3.9	15	85.47	97.37	82.90	94.96	74.96	17.10
	26	5.2	20	85.41	97.36	82.77	94.80	74.36	17.23
	26	6.5	25	85.39	97.34	82.53	94.52	73.32	17.47

Abbreviations: NPV, negative predictive value; PPV, positive predictive value.

Bolded metrics are the most relevant to the threshold, sensitivity, and proportion less than threshold for the low-risk stratification threshold (5 ng/L) and PPV at the URL.

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