Table 2: Open in new tab Hazard ratios...

	Standard Cox model	Time-dependent analyses
AVR procedure (sB-AVR versus TAVR)	1.552 (1.469–1.640)	<0.001	1.510 (1.403–1.625)	<0.001
Year 1					1.073 (0.977–1.178)	0.14	1.044 (0.905–1.203)	0.56
Year 2					1.902 (1.662–2.176)	<0.001	2.006 (1.615–2.492)	<0.001
Year 3					1.746 (1.520–2.005)	<0.001	1.971 (1.589–2.445)	<0.001
Year 4					1.796 (1.563–2.064)	<0.001	1.704 (1.393–2.083)	<0.001
Year >5					1.750 (1.611–1.901)	<0.001	1.574 (1.397–1.774)	<0.001
Age (per 1 year increase)	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001
Sex (male versus female)	0.865 (0.826–0.906)	<0.001	0.872 (0.812–0.937)	<0.001	0.863 (0.824–0.904)	<0.001	0.872 (0.812–0.937)	<0.001
Heart failure^a	1.420 (1.343–1.502)	<0.001	1.373 (1.248–1.511)	<0.001	1.424 (1.346–1.506)	<0.001	1.375 (1.250–1.513)	<0.001
Myocardial Infarction^a	1.166 (1.032–1.317)	0.01	1.427 (1.075–1.894)	0.01	1.158 (1.025–1.308)	0.02	1.425 (1.074–1.891)	0.01
Stroke^a	1.214 (1.031–1.428)	0.02	0.952 (0.573–1.583)	0.85	1.210 (1.029–1.424)	0.02	0.951 (0.572–1.581)	0.85
Diabetes mellitus^a	1.379 (1.303–1.460)	<0.001	1.299 (1.177–1.434)	<0.001	1.381 (1.305–1.461)	<0.001	1.299 (1.177–1.434)	<0.001
Adiposity^a	1.118 (1.021–1.225)	0.02	1.118 (0.936–1.336)	0.22	1.116 (1.019–1.222)	0.02	1.118 (0.936–1.335)	0.22
Hyperlipidemia^a	0.825 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001	0.824 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001
Hyperuricaemia/gout^a	1.089 (0.972–1.219)	0.14	1.121 (0.841–1.496)	0.44	1.091 (0.974–1.222)	0.13	1.120 (0.839–1.493)	0.44
Valvular, rhythmological, other cardiomyopathies^a	0.865 (0.804–0.931)	<0.001	0.837 (0.748–0.937)	0.002	0.866 (0.804–0.932)	<0.001	0.838 (0.748–0.938)	0.002
Ischaemic cardiomyopathy^a	1.079 (1.029–1.132)	0.002	1.122 (1.040–1.209)	0.003	1.079 (1.029–1.132)	0.002	1.121 (1.040–1.208)	0.003
Atherosclerosis^a	1.205 (1.109–1.308)	<0.001	1.229 (1.043–1.448)	0.01	1.204 (1.109–1.307)	<0.001	1.227 (1.042–1.446)	0.01
Pulmonary diseases^a	1.310 (1.167–1.470)	<0.001	1.263 (0.970–1.645)	0.08	1.330 (1.186–1.493)	<0.001	1.267 (0.972–1.650)	0.08
Kidney diseases^a	1.406 (1.322–1.496)	<0.001	1.508 (1.352–1.681)	<0.001	1.410 (1.325–1.500)	<0.001	1.508 (1.353–1.682)	<0.001
Malignant diseases^a	1.424 (1.306–1.553)	<0.001	1.354 (1.136–1.614)	<0.001	1.428 (1.310–1.557)	<0.001	1.359 (1.140–1.620)	<0.001

Standard Cox model

Time-dependent analyses

All patients

Propensity score–matched

All patients

Propensity score–matched

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

AVR procedure (sB-AVR versus TAVR)

1.552 (1.469–1.640)

<0.001

1.510 (1.403–1.625)

<0.001

Year 1

1.073 (0.977–1.178)

0.14

1.044 (0.905–1.203)

0.56

Year 2

1.902 (1.662–2.176)

<0.001

2.006 (1.615–2.492)

<0.001

Year 3

1.746 (1.520–2.005)

<0.001

1.971 (1.589–2.445)

<0.001

Year 4

1.796 (1.563–2.064)

<0.001

1.704 (1.393–2.083)

<0.001

Year >5

1.750 (1.611–1.901)

<0.001

1.574 (1.397–1.774)

<0.001

Age (per 1 year increase)

1.053 (1.049–1.058)

<0.001

1.036 (1.028–1.044)

<0.001

1.053 (1.049–1.058)

<0.001

1.036 (1.028–1.044)

<0.001

Sex (male versus female)

0.865 (0.826–0.906)

<0.001

0.872 (0.812–0.937)

<0.001

0.863 (0.824–0.904)

<0.001

0.872 (0.812–0.937)

<0.001

Heart failure^a

1.420 (1.343–1.502)

<0.001

1.373 (1.248–1.511)

<0.001

1.424 (1.346–1.506)

<0.001

1.375 (1.250–1.513)

<0.001

Myocardial Infarction^a

1.166 (1.032–1.317)

0.01

1.427 (1.075–1.894)

0.01

1.158 (1.025–1.308)

0.02

1.425 (1.074–1.891)

0.01

Stroke^a

1.214 (1.031–1.428)

0.02

0.952 (0.573–1.583)

0.85

1.210 (1.029–1.424)

0.02

0.951 (0.572–1.581)

0.85

Diabetes mellitus^a

1.379 (1.303–1.460)

<0.001

1.299 (1.177–1.434)

<0.001

1.381 (1.305–1.461)

<0.001

1.299 (1.177–1.434)

<0.001

Adiposity^a

1.118 (1.021–1.225)

0.02

1.118 (0.936–1.336)

0.22

1.116 (1.019–1.222)

0.02

1.118 (0.936–1.335)

0.22

Hyperlipidemia^a

0.825 (0.781–0.871)

<0.001

0.822 (0.750–0.900)

<0.001

0.824 (0.781–0.871)

<0.001

0.822 (0.750–0.900)

<0.001

Hyperuricaemia/gout^a

1.089 (0.972–1.219)

0.14

1.121 (0.841–1.496)

0.44

1.091 (0.974–1.222)

0.13

1.120 (0.839–1.493)

0.44

Valvular, rhythmological, other cardiomyopathies^a

0.865 (0.804–0.931)

<0.001

0.837 (0.748–0.937)

0.002

0.866 (0.804–0.932)

<0.001

0.838 (0.748–0.938)

0.002

Ischaemic cardiomyopathy^a

1.079 (1.029–1.132)

0.002

1.122 (1.040–1.209)

0.003

1.079 (1.029–1.132)

0.002

1.121 (1.040–1.208)

0.003

Atherosclerosis^a

1.205 (1.109–1.308)

<0.001

1.229 (1.043–1.448)

0.01

1.204 (1.109–1.307)

<0.001

1.227 (1.042–1.446)

0.01

Pulmonary diseases^a

1.310 (1.167–1.470)

<0.001

1.263 (0.970–1.645)

0.08

1.330 (1.186–1.493)

<0.001

1.267 (0.972–1.650)

0.08

Kidney diseases^a

1.406 (1.322–1.496)

<0.001

1.508 (1.352–1.681)

<0.001

1.410 (1.325–1.500)

<0.001

1.508 (1.353–1.682)

<0.001

Malignant diseases^a

1.424 (1.306–1.553)

<0.001

1.354 (1.136–1.614)

<0.001

1.428 (1.310–1.557)

<0.001

1.359 (1.140–1.620)

<0.001

	Standard Cox model	Time-dependent analyses
AVR procedure (sB-AVR versus TAVR)	1.552 (1.469–1.640)	<0.001	1.510 (1.403–1.625)	<0.001
Year 1					1.073 (0.977–1.178)	0.14	1.044 (0.905–1.203)	0.56
Year 2					1.902 (1.662–2.176)	<0.001	2.006 (1.615–2.492)	<0.001
Year 3					1.746 (1.520–2.005)	<0.001	1.971 (1.589–2.445)	<0.001
Year 4					1.796 (1.563–2.064)	<0.001	1.704 (1.393–2.083)	<0.001
Year >5					1.750 (1.611–1.901)	<0.001	1.574 (1.397–1.774)	<0.001
Age (per 1 year increase)	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001
Sex (male versus female)	0.865 (0.826–0.906)	<0.001	0.872 (0.812–0.937)	<0.001	0.863 (0.824–0.904)	<0.001	0.872 (0.812–0.937)	<0.001
Heart failure^a	1.420 (1.343–1.502)	<0.001	1.373 (1.248–1.511)	<0.001	1.424 (1.346–1.506)	<0.001	1.375 (1.250–1.513)	<0.001
Myocardial Infarction^a	1.166 (1.032–1.317)	0.01	1.427 (1.075–1.894)	0.01	1.158 (1.025–1.308)	0.02	1.425 (1.074–1.891)	0.01
Stroke^a	1.214 (1.031–1.428)	0.02	0.952 (0.573–1.583)	0.85	1.210 (1.029–1.424)	0.02	0.951 (0.572–1.581)	0.85
Diabetes mellitus^a	1.379 (1.303–1.460)	<0.001	1.299 (1.177–1.434)	<0.001	1.381 (1.305–1.461)	<0.001	1.299 (1.177–1.434)	<0.001
Adiposity^a	1.118 (1.021–1.225)	0.02	1.118 (0.936–1.336)	0.22	1.116 (1.019–1.222)	0.02	1.118 (0.936–1.335)	0.22
Hyperlipidemia^a	0.825 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001	0.824 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001
Hyperuricaemia/gout^a	1.089 (0.972–1.219)	0.14	1.121 (0.841–1.496)	0.44	1.091 (0.974–1.222)	0.13	1.120 (0.839–1.493)	0.44
Valvular, rhythmological, other cardiomyopathies^a	0.865 (0.804–0.931)	<0.001	0.837 (0.748–0.937)	0.002	0.866 (0.804–0.932)	<0.001	0.838 (0.748–0.938)	0.002
Ischaemic cardiomyopathy^a	1.079 (1.029–1.132)	0.002	1.122 (1.040–1.209)	0.003	1.079 (1.029–1.132)	0.002	1.121 (1.040–1.208)	0.003
Atherosclerosis^a	1.205 (1.109–1.308)	<0.001	1.229 (1.043–1.448)	0.01	1.204 (1.109–1.307)	<0.001	1.227 (1.042–1.446)	0.01
Pulmonary diseases^a	1.310 (1.167–1.470)	<0.001	1.263 (0.970–1.645)	0.08	1.330 (1.186–1.493)	<0.001	1.267 (0.972–1.650)	0.08
Kidney diseases^a	1.406 (1.322–1.496)	<0.001	1.508 (1.352–1.681)	<0.001	1.410 (1.325–1.500)	<0.001	1.508 (1.353–1.682)	<0.001
Malignant diseases^a	1.424 (1.306–1.553)	<0.001	1.354 (1.136–1.614)	<0.001	1.428 (1.310–1.557)	<0.001	1.359 (1.140–1.620)	<0.001

Standard Cox model

Time-dependent analyses

All patients

Propensity score–matched

All patients

Propensity score–matched

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

AVR procedure (sB-AVR versus TAVR)

1.552 (1.469–1.640)

<0.001

1.510 (1.403–1.625)

<0.001

Year 1

1.073 (0.977–1.178)

0.14

1.044 (0.905–1.203)

0.56

Year 2

1.902 (1.662–2.176)

<0.001

2.006 (1.615–2.492)

<0.001

Year 3

1.746 (1.520–2.005)

<0.001

1.971 (1.589–2.445)

<0.001

Year 4

1.796 (1.563–2.064)

<0.001

1.704 (1.393–2.083)

<0.001

Year >5

1.750 (1.611–1.901)

<0.001

1.574 (1.397–1.774)

<0.001

Age (per 1 year increase)

1.053 (1.049–1.058)

<0.001

1.036 (1.028–1.044)

<0.001

1.053 (1.049–1.058)

<0.001

1.036 (1.028–1.044)

<0.001

Sex (male versus female)

0.865 (0.826–0.906)

<0.001

0.872 (0.812–0.937)

<0.001

0.863 (0.824–0.904)

<0.001

0.872 (0.812–0.937)

<0.001

Heart failure^a

1.420 (1.343–1.502)

<0.001

1.373 (1.248–1.511)

<0.001

1.424 (1.346–1.506)

<0.001

1.375 (1.250–1.513)

<0.001

Myocardial Infarction^a

1.166 (1.032–1.317)

0.01

1.427 (1.075–1.894)

0.01

1.158 (1.025–1.308)

0.02

1.425 (1.074–1.891)

0.01

Stroke^a

1.214 (1.031–1.428)

0.02

0.952 (0.573–1.583)

0.85

1.210 (1.029–1.424)

0.02

0.951 (0.572–1.581)

0.85

Diabetes mellitus^a

1.379 (1.303–1.460)

<0.001

1.299 (1.177–1.434)

<0.001

1.381 (1.305–1.461)

<0.001

1.299 (1.177–1.434)

<0.001

Adiposity^a

1.118 (1.021–1.225)

0.02

1.118 (0.936–1.336)

0.22

1.116 (1.019–1.222)

0.02

1.118 (0.936–1.335)

0.22

Hyperlipidemia^a

0.825 (0.781–0.871)

<0.001

0.822 (0.750–0.900)

<0.001

0.824 (0.781–0.871)

<0.001

0.822 (0.750–0.900)

<0.001

Hyperuricaemia/gout^a

1.089 (0.972–1.219)

0.14

1.121 (0.841–1.496)

0.44

1.091 (0.974–1.222)

0.13

1.120 (0.839–1.493)

0.44

Valvular, rhythmological, other cardiomyopathies^a

0.865 (0.804–0.931)

<0.001

0.837 (0.748–0.937)

0.002

0.866 (0.804–0.932)

<0.001

0.838 (0.748–0.938)

0.002

Ischaemic cardiomyopathy^a

1.079 (1.029–1.132)

0.002

1.122 (1.040–1.209)

0.003

1.079 (1.029–1.132)

0.002

1.121 (1.040–1.208)

0.003

Atherosclerosis^a

1.205 (1.109–1.308)

<0.001

1.229 (1.043–1.448)

0.01

1.204 (1.109–1.307)

<0.001

1.227 (1.042–1.446)

0.01

Pulmonary diseases^a

1.310 (1.167–1.470)

<0.001

1.263 (0.970–1.645)

0.08

1.330 (1.186–1.493)

<0.001

1.267 (0.972–1.650)

0.08

Kidney diseases^a

1.406 (1.322–1.496)

<0.001

1.508 (1.352–1.681)

<0.001

1.410 (1.325–1.500)

<0.001

1.508 (1.353–1.682)

<0.001

Malignant diseases^a

1.424 (1.306–1.553)

<0.001

1.354 (1.136–1.614)

<0.001

1.428 (1.310–1.557)

<0.001

1.359 (1.140–1.620)

<0.001

Table 2:

Open in new tab

Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) from multivariable Cox regression accounting for all listed confounder for all-cause mortality in all patients and the propensity score-matched patients for the standard and time-dependent models (see statistical methods section)

	Standard Cox model				Time-dependent analyses
	All patients		Propensity score–matched		All patients		Propensity score–matched
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
AVR procedure (sB-AVR versus TAVR)	1.552 (1.469–1.640)	<0.001	1.510 (1.403–1.625)	<0.001
Year 1					1.073 (0.977–1.178)	0.14	1.044 (0.905–1.203)	0.56
Year 2					1.902 (1.662–2.176)	<0.001	2.006 (1.615–2.492)	<0.001
Year 3					1.746 (1.520–2.005)	<0.001	1.971 (1.589–2.445)	<0.001
Year 4					1.796 (1.563–2.064)	<0.001	1.704 (1.393–2.083)	<0.001
Year >5					1.750 (1.611–1.901)	<0.001	1.574 (1.397–1.774)	<0.001
Age (per 1 year increase)	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001
Sex (male versus female)	0.865 (0.826–0.906)	<0.001	0.872 (0.812–0.937)	<0.001	0.863 (0.824–0.904)	<0.001	0.872 (0.812–0.937)	<0.001
Heart failure^a	1.420 (1.343–1.502)	<0.001	1.373 (1.248–1.511)	<0.001	1.424 (1.346–1.506)	<0.001	1.375 (1.250–1.513)	<0.001
Myocardial Infarction^a	1.166 (1.032–1.317)	0.01	1.427 (1.075–1.894)	0.01	1.158 (1.025–1.308)	0.02	1.425 (1.074–1.891)	0.01
Stroke^a	1.214 (1.031–1.428)	0.02	0.952 (0.573–1.583)	0.85	1.210 (1.029–1.424)	0.02	0.951 (0.572–1.581)	0.85
Diabetes mellitus^a	1.379 (1.303–1.460)	<0.001	1.299 (1.177–1.434)	<0.001	1.381 (1.305–1.461)	<0.001	1.299 (1.177–1.434)	<0.001
Adiposity^a	1.118 (1.021–1.225)	0.02	1.118 (0.936–1.336)	0.22	1.116 (1.019–1.222)	0.02	1.118 (0.936–1.335)	0.22
Hyperlipidemia^a	0.825 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001	0.824 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001
Hyperuricaemia/gout^a	1.089 (0.972–1.219)	0.14	1.121 (0.841–1.496)	0.44	1.091 (0.974–1.222)	0.13	1.120 (0.839–1.493)	0.44
Valvular, rhythmological, other cardiomyopathies^a	0.865 (0.804–0.931)	<0.001	0.837 (0.748–0.937)	0.002	0.866 (0.804–0.932)	<0.001	0.838 (0.748–0.938)	0.002
Ischaemic cardiomyopathy^a	1.079 (1.029–1.132)	0.002	1.122 (1.040–1.209)	0.003	1.079 (1.029–1.132)	0.002	1.121 (1.040–1.208)	0.003
Atherosclerosis^a	1.205 (1.109–1.308)	<0.001	1.229 (1.043–1.448)	0.01	1.204 (1.109–1.307)	<0.001	1.227 (1.042–1.446)	0.01
Pulmonary diseases^a	1.310 (1.167–1.470)	<0.001	1.263 (0.970–1.645)	0.08	1.330 (1.186–1.493)	<0.001	1.267 (0.972–1.650)	0.08
Kidney diseases^a	1.406 (1.322–1.496)	<0.001	1.508 (1.352–1.681)	<0.001	1.410 (1.325–1.500)	<0.001	1.508 (1.353–1.682)	<0.001
Malignant diseases^a	1.424 (1.306–1.553)	<0.001	1.354 (1.136–1.614)	<0.001	1.428 (1.310–1.557)	<0.001	1.359 (1.140–1.620)	<0.001

	Standard Cox model				Time-dependent analyses
	All patients		Propensity score–matched		All patients		Propensity score–matched
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
AVR procedure (sB-AVR versus TAVR)	1.552 (1.469–1.640)	<0.001	1.510 (1.403–1.625)	<0.001
Year 1					1.073 (0.977–1.178)	0.14	1.044 (0.905–1.203)	0.56
Year 2					1.902 (1.662–2.176)	<0.001	2.006 (1.615–2.492)	<0.001
Year 3					1.746 (1.520–2.005)	<0.001	1.971 (1.589–2.445)	<0.001
Year 4					1.796 (1.563–2.064)	<0.001	1.704 (1.393–2.083)	<0.001
Year >5					1.750 (1.611–1.901)	<0.001	1.574 (1.397–1.774)	<0.001
Age (per 1 year increase)	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001	1.053 (1.049–1.058)	<0.001	1.036 (1.028–1.044)	<0.001
Sex (male versus female)	0.865 (0.826–0.906)	<0.001	0.872 (0.812–0.937)	<0.001	0.863 (0.824–0.904)	<0.001	0.872 (0.812–0.937)	<0.001
Heart failure^a	1.420 (1.343–1.502)	<0.001	1.373 (1.248–1.511)	<0.001	1.424 (1.346–1.506)	<0.001	1.375 (1.250–1.513)	<0.001
Myocardial Infarction^a	1.166 (1.032–1.317)	0.01	1.427 (1.075–1.894)	0.01	1.158 (1.025–1.308)	0.02	1.425 (1.074–1.891)	0.01
Stroke^a	1.214 (1.031–1.428)	0.02	0.952 (0.573–1.583)	0.85	1.210 (1.029–1.424)	0.02	0.951 (0.572–1.581)	0.85
Diabetes mellitus^a	1.379 (1.303–1.460)	<0.001	1.299 (1.177–1.434)	<0.001	1.381 (1.305–1.461)	<0.001	1.299 (1.177–1.434)	<0.001
Adiposity^a	1.118 (1.021–1.225)	0.02	1.118 (0.936–1.336)	0.22	1.116 (1.019–1.222)	0.02	1.118 (0.936–1.335)	0.22
Hyperlipidemia^a	0.825 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001	0.824 (0.781–0.871)	<0.001	0.822 (0.750–0.900)	<0.001
Hyperuricaemia/gout^a	1.089 (0.972–1.219)	0.14	1.121 (0.841–1.496)	0.44	1.091 (0.974–1.222)	0.13	1.120 (0.839–1.493)	0.44
Valvular, rhythmological, other cardiomyopathies^a	0.865 (0.804–0.931)	<0.001	0.837 (0.748–0.937)	0.002	0.866 (0.804–0.932)	<0.001	0.838 (0.748–0.938)	0.002
Ischaemic cardiomyopathy^a	1.079 (1.029–1.132)	0.002	1.122 (1.040–1.209)	0.003	1.079 (1.029–1.132)	0.002	1.121 (1.040–1.208)	0.003
Atherosclerosis^a	1.205 (1.109–1.308)	<0.001	1.229 (1.043–1.448)	0.01	1.204 (1.109–1.307)	<0.001	1.227 (1.042–1.446)	0.01
Pulmonary diseases^a	1.310 (1.167–1.470)	<0.001	1.263 (0.970–1.645)	0.08	1.330 (1.186–1.493)	<0.001	1.267 (0.972–1.650)	0.08
Kidney diseases^a	1.406 (1.322–1.496)	<0.001	1.508 (1.352–1.681)	<0.001	1.410 (1.325–1.500)	<0.001	1.508 (1.353–1.682)	<0.001
Malignant diseases^a	1.424 (1.306–1.553)	<0.001	1.354 (1.136–1.614)	<0.001	1.428 (1.310–1.557)	<0.001	1.359 (1.140–1.620)	<0.001

Present before operation.

sB-AVR: surgical/biological aortic valve replacement; TAVR: transcatheter aortic valve replacement.

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