Total cost of each treatment regimen and monthly cost for newly diagnosed GBM.
| Treatment . | Surgery cost (million JPY) . | Cost for the first 6 months of treatment (including 3 courses of TMZ maintenance therapy) (million JPY) . | Cost for the first 1 year of treatment (including 9 courses of TMZ maintenance therapy) (million JPY) . | Cost for initial treatment without recurrence +12 courses of TMZ maintenance therapy (million JPY) . | Cost per month (million JPY) . | high-cost medical care . | ultra-high-cost medical care . |
|---|---|---|---|---|---|---|---|
| Surgery + RT (60Gy/30fr) + TMZ (Standard of care) (JCOG0911) | 1.32 | 7.95 | 8.85 | 9.3 | 0.74 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation (JCOG1703) | 1.32 | 9.19 | 10.09 | 10.54 | 0.84 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + TTFields | 1.32 | 12.27 | 21.81 | 26.58 | 1.82 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation + TTFields | 1.32 | 13.51 | 23.05 | 27.82 | 1.92 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV | 1.32 | 8.61 | 10.83 | 12.31 | 0.9 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation | 1.32 | 9.85 | 12.07 | 13.55 | 1.01 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + TTFields | 1.32 | 12.93 | 23.79 | 29.59 | 1.98 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation + TTFields | 1.32 | 14.17 | 25.03 | 30.83 | 2.09 | ○ | ○ |
| Treatment . | Surgery cost (million JPY) . | Cost for the first 6 months of treatment (including 3 courses of TMZ maintenance therapy) (million JPY) . | Cost for the first 1 year of treatment (including 9 courses of TMZ maintenance therapy) (million JPY) . | Cost for initial treatment without recurrence +12 courses of TMZ maintenance therapy (million JPY) . | Cost per month (million JPY) . | high-cost medical care . | ultra-high-cost medical care . |
|---|---|---|---|---|---|---|---|
| Surgery + RT (60Gy/30fr) + TMZ (Standard of care) (JCOG0911) | 1.32 | 7.95 | 8.85 | 9.3 | 0.74 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation (JCOG1703) | 1.32 | 9.19 | 10.09 | 10.54 | 0.84 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + TTFields | 1.32 | 12.27 | 21.81 | 26.58 | 1.82 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation + TTFields | 1.32 | 13.51 | 23.05 | 27.82 | 1.92 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV | 1.32 | 8.61 | 10.83 | 12.31 | 0.9 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation | 1.32 | 9.85 | 12.07 | 13.55 | 1.01 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + TTFields | 1.32 | 12.93 | 23.79 | 29.59 | 1.98 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation + TTFields | 1.32 | 14.17 | 25.03 | 30.83 | 2.09 | ○ | ○ |
Abbreviation: RT, radiation therapy; TMZ, temozolomide; TTFields, tumor-treating fields; BEV, bevacizumab; JCOG, Japan Clinical Oncology Group.
Total cost of each treatment regimen and monthly cost for newly diagnosed GBM.
| Treatment . | Surgery cost (million JPY) . | Cost for the first 6 months of treatment (including 3 courses of TMZ maintenance therapy) (million JPY) . | Cost for the first 1 year of treatment (including 9 courses of TMZ maintenance therapy) (million JPY) . | Cost for initial treatment without recurrence +12 courses of TMZ maintenance therapy (million JPY) . | Cost per month (million JPY) . | high-cost medical care . | ultra-high-cost medical care . |
|---|---|---|---|---|---|---|---|
| Surgery + RT (60Gy/30fr) + TMZ (Standard of care) (JCOG0911) | 1.32 | 7.95 | 8.85 | 9.3 | 0.74 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation (JCOG1703) | 1.32 | 9.19 | 10.09 | 10.54 | 0.84 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + TTFields | 1.32 | 12.27 | 21.81 | 26.58 | 1.82 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation + TTFields | 1.32 | 13.51 | 23.05 | 27.82 | 1.92 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV | 1.32 | 8.61 | 10.83 | 12.31 | 0.9 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation | 1.32 | 9.85 | 12.07 | 13.55 | 1.01 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + TTFields | 1.32 | 12.93 | 23.79 | 29.59 | 1.98 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation + TTFields | 1.32 | 14.17 | 25.03 | 30.83 | 2.09 | ○ | ○ |
| Treatment . | Surgery cost (million JPY) . | Cost for the first 6 months of treatment (including 3 courses of TMZ maintenance therapy) (million JPY) . | Cost for the first 1 year of treatment (including 9 courses of TMZ maintenance therapy) (million JPY) . | Cost for initial treatment without recurrence +12 courses of TMZ maintenance therapy (million JPY) . | Cost per month (million JPY) . | high-cost medical care . | ultra-high-cost medical care . |
|---|---|---|---|---|---|---|---|
| Surgery + RT (60Gy/30fr) + TMZ (Standard of care) (JCOG0911) | 1.32 | 7.95 | 8.85 | 9.3 | 0.74 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation (JCOG1703) | 1.32 | 9.19 | 10.09 | 10.54 | 0.84 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + TTFields | 1.32 | 12.27 | 21.81 | 26.58 | 1.82 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + Carmustine wafer implantation + TTFields | 1.32 | 13.51 | 23.05 | 27.82 | 1.92 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV | 1.32 | 8.61 | 10.83 | 12.31 | 0.9 | ○ | |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation | 1.32 | 9.85 | 12.07 | 13.55 | 1.01 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + TTFields | 1.32 | 12.93 | 23.79 | 29.59 | 1.98 | ○ | ○ |
| Surgery + RT (60Gy/30fr) + TMZ + BEV + Carmustine wafer implantation + TTFields | 1.32 | 14.17 | 25.03 | 30.83 | 2.09 | ○ | ○ |
Abbreviation: RT, radiation therapy; TMZ, temozolomide; TTFields, tumor-treating fields; BEV, bevacizumab; JCOG, Japan Clinical Oncology Group.
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