Table 2. Open in new tab Various PK...

Table 2.

Various PK parameters after oral administration of Niclosamide and ASD-5 in SD rats.

Parameter	Unit	Niclosamide	ASD-5	Fold-increase (ASD-5 vs. Niclosamide)
T_max	h	0.83 ± 0.29	0.417 ± 0.144	NA
C_max	ng/ml	279 ± 142	909 ± 150	3.26
AUC_last	h*ng/ml	1005 ± 463	2334 ± 321	2.32
AUC_Inf	h*ng/ml	1024 ± 455	2387 ± 243	2.33

Parameter	Unit	Niclosamide	ASD-5	Fold-increase (ASD-5 vs. Niclosamide)
T_max	h	0.83 ± 0.29	0.417 ± 0.144	NA
C_max	ng/ml	279 ± 142	909 ± 150	3.26
AUC_last	h*ng/ml	1005 ± 463	2334 ± 321	2.32
AUC_Inf	h*ng/ml	1024 ± 455	2387 ± 243	2.33

T_max, time to reach maximum plasma concentration; C_max, maximum plasma concentration; AUC, area under the curve.