| Methylation class . |
|---|
| Adult-type diffuse high-grade glioma, IDH-wildtype, subtypes B, E, and F |
| CNS embryonal tumor with BRD4:LEUTX fusion |
| CNS embryonal tumor with PLAG-family amplification |
| CNS schwannoma, VGLL-fused |
| CNS tumor with BCOR/BCORL1 fusion |
| Dural angioleiomyoma* |
| Glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features |
| Glioneuronal tumor, subtype A |
| High-grade glioma with pleomorphic and pseudopapillary features (HPAP)* |
| Intraocular medulloepithelioma |
| Neuroblastoma, ALT/TERT TMM positive |
| Neuroblastoma, MYCN type |
| Neuroblastoma, TMM negative |
| Neuroepithelial tumor with PATZ1 fusion |
| Neuroepithelial tumor, PLAGL1-fused |
| Olfactory neuroblastoma, IDH-wildtype |
| Oligosarcoma, IDH-mutant** |
| Plasmacytoma of the CNS |
| Retinoblastoma |
| Retinoblastoma, subtype MYCN-altered |
| Sinonasal undifferentiated carcinoma, IDH2-mutant |
| Methylation class . |
|---|
| Adult-type diffuse high-grade glioma, IDH-wildtype, subtypes B, E, and F |
| CNS embryonal tumor with BRD4:LEUTX fusion |
| CNS embryonal tumor with PLAG-family amplification |
| CNS schwannoma, VGLL-fused |
| CNS tumor with BCOR/BCORL1 fusion |
| Dural angioleiomyoma* |
| Glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features |
| Glioneuronal tumor, subtype A |
| High-grade glioma with pleomorphic and pseudopapillary features (HPAP)* |
| Intraocular medulloepithelioma |
| Neuroblastoma, ALT/TERT TMM positive |
| Neuroblastoma, MYCN type |
| Neuroblastoma, TMM negative |
| Neuroepithelial tumor with PATZ1 fusion |
| Neuroepithelial tumor, PLAGL1-fused |
| Olfactory neuroblastoma, IDH-wildtype |
| Oligosarcoma, IDH-mutant** |
| Plasmacytoma of the CNS |
| Retinoblastoma |
| Retinoblastoma, subtype MYCN-altered |
| Sinonasal undifferentiated carcinoma, IDH2-mutant |
*Dural angioleiomyoma and high-grade glioma with pleomorphic and pseudopapillary features (HPAP) are classes in the NCI/Bethesda classifier but are not present in the current Heidelberg classifier.
**Oligosarcoma, IDH-mutant includes some neoplasms that do not harbor IDH mutations and/or 1p/19q-codeletion (see PMID 36520193 and PMID 34967922).
| Methylation class . |
|---|
| Adult-type diffuse high-grade glioma, IDH-wildtype, subtypes B, E, and F |
| CNS embryonal tumor with BRD4:LEUTX fusion |
| CNS embryonal tumor with PLAG-family amplification |
| CNS schwannoma, VGLL-fused |
| CNS tumor with BCOR/BCORL1 fusion |
| Dural angioleiomyoma* |
| Glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features |
| Glioneuronal tumor, subtype A |
| High-grade glioma with pleomorphic and pseudopapillary features (HPAP)* |
| Intraocular medulloepithelioma |
| Neuroblastoma, ALT/TERT TMM positive |
| Neuroblastoma, MYCN type |
| Neuroblastoma, TMM negative |
| Neuroepithelial tumor with PATZ1 fusion |
| Neuroepithelial tumor, PLAGL1-fused |
| Olfactory neuroblastoma, IDH-wildtype |
| Oligosarcoma, IDH-mutant** |
| Plasmacytoma of the CNS |
| Retinoblastoma |
| Retinoblastoma, subtype MYCN-altered |
| Sinonasal undifferentiated carcinoma, IDH2-mutant |
| Methylation class . |
|---|
| Adult-type diffuse high-grade glioma, IDH-wildtype, subtypes B, E, and F |
| CNS embryonal tumor with BRD4:LEUTX fusion |
| CNS embryonal tumor with PLAG-family amplification |
| CNS schwannoma, VGLL-fused |
| CNS tumor with BCOR/BCORL1 fusion |
| Dural angioleiomyoma* |
| Glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features |
| Glioneuronal tumor, subtype A |
| High-grade glioma with pleomorphic and pseudopapillary features (HPAP)* |
| Intraocular medulloepithelioma |
| Neuroblastoma, ALT/TERT TMM positive |
| Neuroblastoma, MYCN type |
| Neuroblastoma, TMM negative |
| Neuroepithelial tumor with PATZ1 fusion |
| Neuroepithelial tumor, PLAGL1-fused |
| Olfactory neuroblastoma, IDH-wildtype |
| Oligosarcoma, IDH-mutant** |
| Plasmacytoma of the CNS |
| Retinoblastoma |
| Retinoblastoma, subtype MYCN-altered |
| Sinonasal undifferentiated carcinoma, IDH2-mutant |
*Dural angioleiomyoma and high-grade glioma with pleomorphic and pseudopapillary features (HPAP) are classes in the NCI/Bethesda classifier but are not present in the current Heidelberg classifier.
**Oligosarcoma, IDH-mutant includes some neoplasms that do not harbor IDH mutations and/or 1p/19q-codeletion (see PMID 36520193 and PMID 34967922).
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