| Criteria . | Drug Names/Classes . | Mechanism . |
|---|---|---|
| A1 | amitriptyline, nortriptyline, doxepin, clomipramine, imipramine, desipramine, amoxapine, protriptyline, trimipramine Paroxetine Phenelzine | Anticholinergic effects |
| A2 | trospium chloride, tolterodine, fesoterodine, oxybutynin, solifenacin, darifenacin | Anticholinergic effects |
| A3 | dicyclomine hydrochloride, hyoscine hydrobromide | Anticholinergic effects |
| A4 | diphenhydramine, promethazine, dimenhydrinate, chlorpheniramine | Anticholinergic effects |
| A5 | First generation: chlorpromazine, flupenthixol, fluphenazine, haloperidol, loxapine, pimozide, sulpiride, trifluoperazine, zuclopenthixol, levomepromazine Second generation: olanzapine, quetiapine, clozapine, aripiprazole, risperidone | Anticholinergic effects & sedative effects |
| A6 | See https://www.acbcalc.com/ See ACBCalc® scorecard below | Anticholinergic effects |
| B1 | triazolam, lormetazepam, lorprazolam, nitrazepam, temazepam, flurazepam | Sedative effects |
| B2 | alprazolam, chlordiazepoxide, diazepam, oxazepam, clonazepam, clobazam | Sedative effects |
| B3 | zopiclone, zolpidem, zaleplon | Sedative effects |
| C1 | benztropine, trihexyphenidyl, procyclidine, biperidin | Anticholinergic effects |
| C2 | amantadine | Risk of psychosis |
| C3 | pramipexole, ropinirole, apomorphine hydrochloride, rotigotine | Risk of psychosis |
| C4 | rasagiline, selegiline, safinamide | Risk of psychosis |
| C5 | entacapone, tolcapone, opicapone | Risk of psychosis |
| D1 | oxycodone, morphine, codeine, fentanyl, tramadol, pethidine | Sedative effects |
| D2 | pregabalin, gabapentin | Sedative effects |
| D3 | topiramate, carbamazepine, clonazepam, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, phenytoin, pregabalin, valproate | Sedative effects |
| D4 | baclofen, tizanidine, pridinol, dantrolene | Sedative effects |
| E1 | Eugeroics: modafinil ADHD drugs: methylphenidate, lisdexamphetamine, dexamphetamine Nootropic supplements: B vitamins, fish oil supplements, herbal supplements including ginkgo biloba Nootropic racetams: piracetam, aniracetam, etc. | No proven efficacy |
| F1 | donepezil, rivastigmine, galantamine | No proven efficacy in severe dementia |
| F2 | memantine | No proven efficacy in severe dementia |
| F3 | lecanemab, aducanumab, donanemab | No proven efficacy in severe dementia |
| F4 | statins, antiplatelet agents, anticoagulants, antihypertensives, bisphosphonates | No proven efficacy in severe dementia |
| Criteria . | Drug Names/Classes . | Mechanism . |
|---|---|---|
| A1 | amitriptyline, nortriptyline, doxepin, clomipramine, imipramine, desipramine, amoxapine, protriptyline, trimipramine Paroxetine Phenelzine | Anticholinergic effects |
| A2 | trospium chloride, tolterodine, fesoterodine, oxybutynin, solifenacin, darifenacin | Anticholinergic effects |
| A3 | dicyclomine hydrochloride, hyoscine hydrobromide | Anticholinergic effects |
| A4 | diphenhydramine, promethazine, dimenhydrinate, chlorpheniramine | Anticholinergic effects |
| A5 | First generation: chlorpromazine, flupenthixol, fluphenazine, haloperidol, loxapine, pimozide, sulpiride, trifluoperazine, zuclopenthixol, levomepromazine Second generation: olanzapine, quetiapine, clozapine, aripiprazole, risperidone | Anticholinergic effects & sedative effects |
| A6 | See https://www.acbcalc.com/ See ACBCalc® scorecard below | Anticholinergic effects |
| B1 | triazolam, lormetazepam, lorprazolam, nitrazepam, temazepam, flurazepam | Sedative effects |
| B2 | alprazolam, chlordiazepoxide, diazepam, oxazepam, clonazepam, clobazam | Sedative effects |
| B3 | zopiclone, zolpidem, zaleplon | Sedative effects |
| C1 | benztropine, trihexyphenidyl, procyclidine, biperidin | Anticholinergic effects |
| C2 | amantadine | Risk of psychosis |
| C3 | pramipexole, ropinirole, apomorphine hydrochloride, rotigotine | Risk of psychosis |
| C4 | rasagiline, selegiline, safinamide | Risk of psychosis |
| C5 | entacapone, tolcapone, opicapone | Risk of psychosis |
| D1 | oxycodone, morphine, codeine, fentanyl, tramadol, pethidine | Sedative effects |
| D2 | pregabalin, gabapentin | Sedative effects |
| D3 | topiramate, carbamazepine, clonazepam, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, phenytoin, pregabalin, valproate | Sedative effects |
| D4 | baclofen, tizanidine, pridinol, dantrolene | Sedative effects |
| E1 | Eugeroics: modafinil ADHD drugs: methylphenidate, lisdexamphetamine, dexamphetamine Nootropic supplements: B vitamins, fish oil supplements, herbal supplements including ginkgo biloba Nootropic racetams: piracetam, aniracetam, etc. | No proven efficacy |
| F1 | donepezil, rivastigmine, galantamine | No proven efficacy in severe dementia |
| F2 | memantine | No proven efficacy in severe dementia |
| F3 | lecanemab, aducanumab, donanemab | No proven efficacy in severe dementia |
| F4 | statins, antiplatelet agents, anticoagulants, antihypertensives, bisphosphonates | No proven efficacy in severe dementia |
| Criteria . | Drug Names/Classes . | Mechanism . |
|---|---|---|
| A1 | amitriptyline, nortriptyline, doxepin, clomipramine, imipramine, desipramine, amoxapine, protriptyline, trimipramine Paroxetine Phenelzine | Anticholinergic effects |
| A2 | trospium chloride, tolterodine, fesoterodine, oxybutynin, solifenacin, darifenacin | Anticholinergic effects |
| A3 | dicyclomine hydrochloride, hyoscine hydrobromide | Anticholinergic effects |
| A4 | diphenhydramine, promethazine, dimenhydrinate, chlorpheniramine | Anticholinergic effects |
| A5 | First generation: chlorpromazine, flupenthixol, fluphenazine, haloperidol, loxapine, pimozide, sulpiride, trifluoperazine, zuclopenthixol, levomepromazine Second generation: olanzapine, quetiapine, clozapine, aripiprazole, risperidone | Anticholinergic effects & sedative effects |
| A6 | See https://www.acbcalc.com/ See ACBCalc® scorecard below | Anticholinergic effects |
| B1 | triazolam, lormetazepam, lorprazolam, nitrazepam, temazepam, flurazepam | Sedative effects |
| B2 | alprazolam, chlordiazepoxide, diazepam, oxazepam, clonazepam, clobazam | Sedative effects |
| B3 | zopiclone, zolpidem, zaleplon | Sedative effects |
| C1 | benztropine, trihexyphenidyl, procyclidine, biperidin | Anticholinergic effects |
| C2 | amantadine | Risk of psychosis |
| C3 | pramipexole, ropinirole, apomorphine hydrochloride, rotigotine | Risk of psychosis |
| C4 | rasagiline, selegiline, safinamide | Risk of psychosis |
| C5 | entacapone, tolcapone, opicapone | Risk of psychosis |
| D1 | oxycodone, morphine, codeine, fentanyl, tramadol, pethidine | Sedative effects |
| D2 | pregabalin, gabapentin | Sedative effects |
| D3 | topiramate, carbamazepine, clonazepam, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, phenytoin, pregabalin, valproate | Sedative effects |
| D4 | baclofen, tizanidine, pridinol, dantrolene | Sedative effects |
| E1 | Eugeroics: modafinil ADHD drugs: methylphenidate, lisdexamphetamine, dexamphetamine Nootropic supplements: B vitamins, fish oil supplements, herbal supplements including ginkgo biloba Nootropic racetams: piracetam, aniracetam, etc. | No proven efficacy |
| F1 | donepezil, rivastigmine, galantamine | No proven efficacy in severe dementia |
| F2 | memantine | No proven efficacy in severe dementia |
| F3 | lecanemab, aducanumab, donanemab | No proven efficacy in severe dementia |
| F4 | statins, antiplatelet agents, anticoagulants, antihypertensives, bisphosphonates | No proven efficacy in severe dementia |
| Criteria . | Drug Names/Classes . | Mechanism . |
|---|---|---|
| A1 | amitriptyline, nortriptyline, doxepin, clomipramine, imipramine, desipramine, amoxapine, protriptyline, trimipramine Paroxetine Phenelzine | Anticholinergic effects |
| A2 | trospium chloride, tolterodine, fesoterodine, oxybutynin, solifenacin, darifenacin | Anticholinergic effects |
| A3 | dicyclomine hydrochloride, hyoscine hydrobromide | Anticholinergic effects |
| A4 | diphenhydramine, promethazine, dimenhydrinate, chlorpheniramine | Anticholinergic effects |
| A5 | First generation: chlorpromazine, flupenthixol, fluphenazine, haloperidol, loxapine, pimozide, sulpiride, trifluoperazine, zuclopenthixol, levomepromazine Second generation: olanzapine, quetiapine, clozapine, aripiprazole, risperidone | Anticholinergic effects & sedative effects |
| A6 | See https://www.acbcalc.com/ See ACBCalc® scorecard below | Anticholinergic effects |
| B1 | triazolam, lormetazepam, lorprazolam, nitrazepam, temazepam, flurazepam | Sedative effects |
| B2 | alprazolam, chlordiazepoxide, diazepam, oxazepam, clonazepam, clobazam | Sedative effects |
| B3 | zopiclone, zolpidem, zaleplon | Sedative effects |
| C1 | benztropine, trihexyphenidyl, procyclidine, biperidin | Anticholinergic effects |
| C2 | amantadine | Risk of psychosis |
| C3 | pramipexole, ropinirole, apomorphine hydrochloride, rotigotine | Risk of psychosis |
| C4 | rasagiline, selegiline, safinamide | Risk of psychosis |
| C5 | entacapone, tolcapone, opicapone | Risk of psychosis |
| D1 | oxycodone, morphine, codeine, fentanyl, tramadol, pethidine | Sedative effects |
| D2 | pregabalin, gabapentin | Sedative effects |
| D3 | topiramate, carbamazepine, clonazepam, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, phenytoin, pregabalin, valproate | Sedative effects |
| D4 | baclofen, tizanidine, pridinol, dantrolene | Sedative effects |
| E1 | Eugeroics: modafinil ADHD drugs: methylphenidate, lisdexamphetamine, dexamphetamine Nootropic supplements: B vitamins, fish oil supplements, herbal supplements including ginkgo biloba Nootropic racetams: piracetam, aniracetam, etc. | No proven efficacy |
| F1 | donepezil, rivastigmine, galantamine | No proven efficacy in severe dementia |
| F2 | memantine | No proven efficacy in severe dementia |
| F3 | lecanemab, aducanumab, donanemab | No proven efficacy in severe dementia |
| F4 | statins, antiplatelet agents, anticoagulants, antihypertensives, bisphosphonates | No proven efficacy in severe dementia |
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
