Comparison of biochemical markers, ectopic ossifications, and leg deformity with and without PHEX zinc binding site
| . | With zinc binding site (n = 18) . | Without zinc binding site (n = 6) . | P . |
|---|---|---|---|
| Height, SD | −2.3 (−4.8 to 0.7) | −2.3 (−3.2 to −0.5) | .79 |
| Serum FGF23, pg/mLa | 94.3 (54.0-1317.8) | 113.8 (48.9-945.6) | .74 |
| Plasma PPi, nM | 2288 (1185-4000) | 2399 (1474-2780) | .80 |
| OALL, n (%) | 11 (61) | 3 (50) | .67 |
| OPLL, n (%) | 6 (33) | 1 (17) | .63 |
| OYL, n (%) | 14 (78) | 4 (66.7) | .62 |
| Osteophytes around hip joints, n (%) | 19 (100) | 6 (100) | ≥.999 |
| Osteophytes around knee joints, n (%) | 11 (61) | 6 (100) | .13 |
| OA index | 2 (0-22) | 3 (0-15) | .89 |
| OP index | 0 (0-15) | 0 (0-14) | .56 |
| OY index | 8 (0-13) | 4 (0-9) | .33 |
| OS index | 12 (0-41) | 7 (0-38) | .46 |
| Hip KL grade | 3 (2-4) | 3 (2-4) | .66 |
| Knee KL grade | 2 (0-4) | 3 (2-3) | .41 |
| Varus deformity, n (%) | 8 (44) | 4 (67) | .64 |
| Valgus deformity, n (%) | 5 (28) | 0 (0) | .28 |
| . | With zinc binding site (n = 18) . | Without zinc binding site (n = 6) . | P . |
|---|---|---|---|
| Height, SD | −2.3 (−4.8 to 0.7) | −2.3 (−3.2 to −0.5) | .79 |
| Serum FGF23, pg/mLa | 94.3 (54.0-1317.8) | 113.8 (48.9-945.6) | .74 |
| Plasma PPi, nM | 2288 (1185-4000) | 2399 (1474-2780) | .80 |
| OALL, n (%) | 11 (61) | 3 (50) | .67 |
| OPLL, n (%) | 6 (33) | 1 (17) | .63 |
| OYL, n (%) | 14 (78) | 4 (66.7) | .62 |
| Osteophytes around hip joints, n (%) | 19 (100) | 6 (100) | ≥.999 |
| Osteophytes around knee joints, n (%) | 11 (61) | 6 (100) | .13 |
| OA index | 2 (0-22) | 3 (0-15) | .89 |
| OP index | 0 (0-15) | 0 (0-14) | .56 |
| OY index | 8 (0-13) | 4 (0-9) | .33 |
| OS index | 12 (0-41) | 7 (0-38) | .46 |
| Hip KL grade | 3 (2-4) | 3 (2-4) | .66 |
| Knee KL grade | 2 (0-4) | 3 (2-3) | .41 |
| Varus deformity, n (%) | 8 (44) | 4 (67) | .64 |
| Valgus deformity, n (%) | 5 (28) | 0 (0) | .28 |
Values are reported as median (range).
Abbreviations: FGF, fibroblast growth factor; KL; Kellgren-Lawrence; OA index, ossification of the anterior longitudinal ligament index; OALL, ossification of the anterior longitudinal ligament; OP, ossification of the posterior longitudinal ligament index; OPLL, ossification of the posterior longitudinal ligament; OS index, ossification index; OY index, ossification of the yellow ligament index; OYL, ossification of the yellow ligament.
aSerum FGF23 levels were compared after excluding patients with estimated glomerular filtration rate lower than 60 mL/min/1.73 m2.
Comparison of biochemical markers, ectopic ossifications, and leg deformity with and without PHEX zinc binding site
| . | With zinc binding site (n = 18) . | Without zinc binding site (n = 6) . | P . |
|---|---|---|---|
| Height, SD | −2.3 (−4.8 to 0.7) | −2.3 (−3.2 to −0.5) | .79 |
| Serum FGF23, pg/mLa | 94.3 (54.0-1317.8) | 113.8 (48.9-945.6) | .74 |
| Plasma PPi, nM | 2288 (1185-4000) | 2399 (1474-2780) | .80 |
| OALL, n (%) | 11 (61) | 3 (50) | .67 |
| OPLL, n (%) | 6 (33) | 1 (17) | .63 |
| OYL, n (%) | 14 (78) | 4 (66.7) | .62 |
| Osteophytes around hip joints, n (%) | 19 (100) | 6 (100) | ≥.999 |
| Osteophytes around knee joints, n (%) | 11 (61) | 6 (100) | .13 |
| OA index | 2 (0-22) | 3 (0-15) | .89 |
| OP index | 0 (0-15) | 0 (0-14) | .56 |
| OY index | 8 (0-13) | 4 (0-9) | .33 |
| OS index | 12 (0-41) | 7 (0-38) | .46 |
| Hip KL grade | 3 (2-4) | 3 (2-4) | .66 |
| Knee KL grade | 2 (0-4) | 3 (2-3) | .41 |
| Varus deformity, n (%) | 8 (44) | 4 (67) | .64 |
| Valgus deformity, n (%) | 5 (28) | 0 (0) | .28 |
| . | With zinc binding site (n = 18) . | Without zinc binding site (n = 6) . | P . |
|---|---|---|---|
| Height, SD | −2.3 (−4.8 to 0.7) | −2.3 (−3.2 to −0.5) | .79 |
| Serum FGF23, pg/mLa | 94.3 (54.0-1317.8) | 113.8 (48.9-945.6) | .74 |
| Plasma PPi, nM | 2288 (1185-4000) | 2399 (1474-2780) | .80 |
| OALL, n (%) | 11 (61) | 3 (50) | .67 |
| OPLL, n (%) | 6 (33) | 1 (17) | .63 |
| OYL, n (%) | 14 (78) | 4 (66.7) | .62 |
| Osteophytes around hip joints, n (%) | 19 (100) | 6 (100) | ≥.999 |
| Osteophytes around knee joints, n (%) | 11 (61) | 6 (100) | .13 |
| OA index | 2 (0-22) | 3 (0-15) | .89 |
| OP index | 0 (0-15) | 0 (0-14) | .56 |
| OY index | 8 (0-13) | 4 (0-9) | .33 |
| OS index | 12 (0-41) | 7 (0-38) | .46 |
| Hip KL grade | 3 (2-4) | 3 (2-4) | .66 |
| Knee KL grade | 2 (0-4) | 3 (2-3) | .41 |
| Varus deformity, n (%) | 8 (44) | 4 (67) | .64 |
| Valgus deformity, n (%) | 5 (28) | 0 (0) | .28 |
Values are reported as median (range).
Abbreviations: FGF, fibroblast growth factor; KL; Kellgren-Lawrence; OA index, ossification of the anterior longitudinal ligament index; OALL, ossification of the anterior longitudinal ligament; OP, ossification of the posterior longitudinal ligament index; OPLL, ossification of the posterior longitudinal ligament; OS index, ossification index; OY index, ossification of the yellow ligament index; OYL, ossification of the yellow ligament.
aSerum FGF23 levels were compared after excluding patients with estimated glomerular filtration rate lower than 60 mL/min/1.73 m2.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
