Table 2 Open in new tab Main adverse...

Medication

Adverse effects

Contraindications

Orlistat

Gastrointestinal symptoms: oily rectal leakage, abdominal pain, flatulence with discharge, faecal urgency, steatorrhoea, faecal incontinence, increased defaecation

Chronic malabsorption syndrome; cholestasis;
pregnancy

Naltrexone/bupropion

Gastrointestinal symptoms: nausea, constipation, vomiting, diarrhoea, dry mouth
Symptoms of the central nervous system: headaches, insomnia, sleep disorders

Chronic opioid use; acute opioid withdrawal; uncontrolled hypertension; seizure disorder; bulimia or anorexia nervosa; abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiseizure drugs; concomitant use of monoamine oxidase inhibitors; pregnancy

Liraglutide

Gastrointestinal symptoms: nausea, vomiting, diarrhoea, constipation
Symptoms of the central nervous system: headache

Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy

Semaglutide

Gastrointestinal symptoms: nausea, diarrhoea, vomiting, constipation, dyspepsia
Symptoms of the central nervous system: headache

Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy

Tirzepatide

Gastrointestinal symptoms: Nausea, diarrhoea, decreased appetite, vomiting, constipation, dyspepsia, abdominal pain

Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy, known serious hypersensitivity to tirzepatide or any of the excipients

Setmelanotide

Hypersensitivity reaction at injection site, hyperpigmentation, sexual dysfunction

Pregnancy

Table 2

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Main adverse effects and contraindications for approved anti-obesity medications

Medication	Adverse effects	Contraindications
Orlistat	Gastrointestinal symptoms: oily rectal leakage, abdominal pain, flatulence with discharge, faecal urgency, steatorrhoea, faecal incontinence, increased defaecation	Chronic malabsorption syndrome; cholestasis; pregnancy
Naltrexone/bupropion	Gastrointestinal symptoms: nausea, constipation, vomiting, diarrhoea, dry mouth Symptoms of the central nervous system: headaches, insomnia, sleep disorders	Chronic opioid use; acute opioid withdrawal; uncontrolled hypertension; seizure disorder; bulimia or anorexia nervosa; abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiseizure drugs; concomitant use of monoamine oxidase inhibitors; pregnancy
Liraglutide	Gastrointestinal symptoms: nausea, vomiting, diarrhoea, constipation Symptoms of the central nervous system: headache	Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy
Semaglutide	Gastrointestinal symptoms: nausea, diarrhoea, vomiting, constipation, dyspepsia Symptoms of the central nervous system: headache	Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy
Tirzepatide	Gastrointestinal symptoms: Nausea, diarrhoea, decreased appetite, vomiting, constipation, dyspepsia, abdominal pain	Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy, known serious hypersensitivity to tirzepatide or any of the excipients
Setmelanotide	Hypersensitivity reaction at injection site, hyperpigmentation, sexual dysfunction	Pregnancy

Medication	Adverse effects	Contraindications
Orlistat	Gastrointestinal symptoms: oily rectal leakage, abdominal pain, flatulence with discharge, faecal urgency, steatorrhoea, faecal incontinence, increased defaecation	Chronic malabsorption syndrome; cholestasis; pregnancy
Naltrexone/bupropion	Gastrointestinal symptoms: nausea, constipation, vomiting, diarrhoea, dry mouth Symptoms of the central nervous system: headaches, insomnia, sleep disorders	Chronic opioid use; acute opioid withdrawal; uncontrolled hypertension; seizure disorder; bulimia or anorexia nervosa; abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiseizure drugs; concomitant use of monoamine oxidase inhibitors; pregnancy
Liraglutide	Gastrointestinal symptoms: nausea, vomiting, diarrhoea, constipation Symptoms of the central nervous system: headache	Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy
Semaglutide	Gastrointestinal symptoms: nausea, diarrhoea, vomiting, constipation, dyspepsia Symptoms of the central nervous system: headache	Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy
Tirzepatide	Gastrointestinal symptoms: Nausea, diarrhoea, decreased appetite, vomiting, constipation, dyspepsia, abdominal pain	Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pregnancy, known serious hypersensitivity to tirzepatide or any of the excipients
Setmelanotide	Hypersensitivity reaction at injection site, hyperpigmentation, sexual dysfunction	Pregnancy

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