Concentrations of amitriptyline and nortriptyline in postmortem femoral blood and brain tissue presented as median values and 10–90 percentiles
| . | . | . | Amitriptyline conc. (mg/kg) . | Nortriptyline conc. (mg/kg) . | The sum of amitriptyline and nortriptyline conc. (mg/kg) . | |||
|---|---|---|---|---|---|---|---|---|
| . | Classa . | n . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . |
| Amitriptyline cases | ||||||||
| Femoral blood | A | 5 | 1.8 | 0.65–5.5 | 1.0 | 0.37–1.9 | 3.6 | 1.0–7.0 |
| B | 6 | 0.58 | 0.31–3.5 | 0.43 | 0.35–0.59 | 1.0 | 0.66–4.1 | |
| C | 31 | 0.15 | 0.033–0.48 | 0.10 | 0.030–0.42 | 0.23 | 0.076–1.0 | |
| Total | 42 | 0.26 | 0.042–1.7 | 0.14 | 0.032–0.90 | 0.39 | 0.085–2.2 | |
| Brain tissue | A | 5 | 9.3 | 3.4–28 | 5.0 | 2.7–17 | 19 | 6.2–40 |
| B | 6 | 2.1 | 1.0–14 | 2.7 | 2.5–4.1 | 4.5 | 3.7–18 | |
| C | 31 | 0.39 | 0.16–1.5 | 0.82 | 0.19–3.7 | 1.1 | 0.49–5.7 | |
| Total | 42 | 0.78 | 0.17–9.1 | 1.43 | 0.22–5.0 | 2.3 | 0.53–18 | |
| Nortriptyline cases | ||||||||
| Femoral blood | C | 11 | 0.28 | 0.042–1.0 | ||||
| Brain tissue | C | 11 | 3 | 0.32–7.2 | ||||
| . | . | . | Amitriptyline conc. (mg/kg) . | Nortriptyline conc. (mg/kg) . | The sum of amitriptyline and nortriptyline conc. (mg/kg) . | |||
|---|---|---|---|---|---|---|---|---|
| . | Classa . | n . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . |
| Amitriptyline cases | ||||||||
| Femoral blood | A | 5 | 1.8 | 0.65–5.5 | 1.0 | 0.37–1.9 | 3.6 | 1.0–7.0 |
| B | 6 | 0.58 | 0.31–3.5 | 0.43 | 0.35–0.59 | 1.0 | 0.66–4.1 | |
| C | 31 | 0.15 | 0.033–0.48 | 0.10 | 0.030–0.42 | 0.23 | 0.076–1.0 | |
| Total | 42 | 0.26 | 0.042–1.7 | 0.14 | 0.032–0.90 | 0.39 | 0.085–2.2 | |
| Brain tissue | A | 5 | 9.3 | 3.4–28 | 5.0 | 2.7–17 | 19 | 6.2–40 |
| B | 6 | 2.1 | 1.0–14 | 2.7 | 2.5–4.1 | 4.5 | 3.7–18 | |
| C | 31 | 0.39 | 0.16–1.5 | 0.82 | 0.19–3.7 | 1.1 | 0.49–5.7 | |
| Total | 42 | 0.78 | 0.17–9.1 | 1.43 | 0.22–5.0 | 2.3 | 0.53–18 | |
| Nortriptyline cases | ||||||||
| Femoral blood | C | 11 | 0.28 | 0.042–1.0 | ||||
| Brain tissue | C | 11 | 3 | 0.32–7.2 | ||||
Class A: Cases where amitriptyline and/or nortriptyline solely caused a lethal intoxication. Class B: Cases where amitriptyline and/or nortriptyline contributed to the cause of death. Class C: Cases, where either amitriptyline or nortriptyline was involved in the cause of death.
Concentrations of amitriptyline and nortriptyline in postmortem femoral blood and brain tissue presented as median values and 10–90 percentiles
| . | . | . | Amitriptyline conc. (mg/kg) . | Nortriptyline conc. (mg/kg) . | The sum of amitriptyline and nortriptyline conc. (mg/kg) . | |||
|---|---|---|---|---|---|---|---|---|
| . | Classa . | n . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . |
| Amitriptyline cases | ||||||||
| Femoral blood | A | 5 | 1.8 | 0.65–5.5 | 1.0 | 0.37–1.9 | 3.6 | 1.0–7.0 |
| B | 6 | 0.58 | 0.31–3.5 | 0.43 | 0.35–0.59 | 1.0 | 0.66–4.1 | |
| C | 31 | 0.15 | 0.033–0.48 | 0.10 | 0.030–0.42 | 0.23 | 0.076–1.0 | |
| Total | 42 | 0.26 | 0.042–1.7 | 0.14 | 0.032–0.90 | 0.39 | 0.085–2.2 | |
| Brain tissue | A | 5 | 9.3 | 3.4–28 | 5.0 | 2.7–17 | 19 | 6.2–40 |
| B | 6 | 2.1 | 1.0–14 | 2.7 | 2.5–4.1 | 4.5 | 3.7–18 | |
| C | 31 | 0.39 | 0.16–1.5 | 0.82 | 0.19–3.7 | 1.1 | 0.49–5.7 | |
| Total | 42 | 0.78 | 0.17–9.1 | 1.43 | 0.22–5.0 | 2.3 | 0.53–18 | |
| Nortriptyline cases | ||||||||
| Femoral blood | C | 11 | 0.28 | 0.042–1.0 | ||||
| Brain tissue | C | 11 | 3 | 0.32–7.2 | ||||
| . | . | . | Amitriptyline conc. (mg/kg) . | Nortriptyline conc. (mg/kg) . | The sum of amitriptyline and nortriptyline conc. (mg/kg) . | |||
|---|---|---|---|---|---|---|---|---|
| . | Classa . | n . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . | Median . | 10–90 percentiles . |
| Amitriptyline cases | ||||||||
| Femoral blood | A | 5 | 1.8 | 0.65–5.5 | 1.0 | 0.37–1.9 | 3.6 | 1.0–7.0 |
| B | 6 | 0.58 | 0.31–3.5 | 0.43 | 0.35–0.59 | 1.0 | 0.66–4.1 | |
| C | 31 | 0.15 | 0.033–0.48 | 0.10 | 0.030–0.42 | 0.23 | 0.076–1.0 | |
| Total | 42 | 0.26 | 0.042–1.7 | 0.14 | 0.032–0.90 | 0.39 | 0.085–2.2 | |
| Brain tissue | A | 5 | 9.3 | 3.4–28 | 5.0 | 2.7–17 | 19 | 6.2–40 |
| B | 6 | 2.1 | 1.0–14 | 2.7 | 2.5–4.1 | 4.5 | 3.7–18 | |
| C | 31 | 0.39 | 0.16–1.5 | 0.82 | 0.19–3.7 | 1.1 | 0.49–5.7 | |
| Total | 42 | 0.78 | 0.17–9.1 | 1.43 | 0.22–5.0 | 2.3 | 0.53–18 | |
| Nortriptyline cases | ||||||||
| Femoral blood | C | 11 | 0.28 | 0.042–1.0 | ||||
| Brain tissue | C | 11 | 3 | 0.32–7.2 | ||||
Class A: Cases where amitriptyline and/or nortriptyline solely caused a lethal intoxication. Class B: Cases where amitriptyline and/or nortriptyline contributed to the cause of death. Class C: Cases, where either amitriptyline or nortriptyline was involved in the cause of death.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
