| Baseline echocardiographic parameters . | |||||
|---|---|---|---|---|---|
| Overall . | Fused . | Two-sinus . | Partial fusion . | P-value . | |
| LVEDD (mm), median (IQR) | 50 (46–55) | 49 (46–55) | 50 (44–56.8) | 50 (46–54.5) | 0.921 |
| LVEDVi (ml/m2), median (IQR) | 68 (54.1–81.5) | 68 (53.2–82) | 66 (53–82) | 70 (61.7–83.7) | 0.812 |
| Cardiac mass index (g/m2), median (IQR) | 105 (88–130) | 104 (87–128) | 106 (89–142) | 131 (93–160.6) | 0.150 |
| RWT, median (IQR) | 0.42 (0.38–0.49) | 0.41 (0.37–0.48) | 0.43 (0.35–0.51) | 0.47 (0.41–0.55) | 0.301 |
| LVEF (%), median (IQR) | 60 (56–62) | 60 (56–62) | 60 (56–61) | 60 (56.5–64.5) | 0.675 |
| TAPSE (mm), median (IQR) | 23 (20–26) | 23 (20–26) | 22 (20–26) | 23 (20–25) | 0.777 |
| PAPs (mmHg), median (IQR) | 30 (25–35) | 30 (25–35) | 30 (25–35) | 28.5 (25–35) | 0.912 |
| Aortic stenosis, n (%) | 189 (62.6) | 149 (60.8) | 26 (61.9) | 14 (87.5) | 0.213 |
| Mild, n (%) | 32 (10.6) | 27 (11) | 3 (7.3) | 1 (6.3) | 0.664 |
| Moderate, n (%) | 59 (19.5) | 50 (20.4) | 5 (12.2) | 4 (25) | 0.314 |
| Severe, n (%) | 98 (32.5) | 67 (27.3) | 22 (52.4) | 9 (56.3) | 0.123 |
| Aortic regurgitation, n (%) | 263 (87) | 212 (86.5) | 36 (85.7) | 15 (93.8) | 0.624 |
| Mild, n (%) | 144 (47.7) | 115 (46.9) | 24 (58.5) | 5 (31.3) | 0.041 |
| Moderate, n (%) | 56 (18.5) | 38 (15.5) | 9 (22) | 9 (56.3) | <0.001 |
| Severe, n (%) | 63 (20.9) | 50 (20.4) | 11 (26.2) | 2 (12.5) | 0.398 |
| Combined aortic valve disease, n (%) | 150 (49.7) | 121 (49.4) | 16 (39) | 13 (81.3) | 0.023 |
| Severe combined aortic valve disease, n (%) | 6 (2) | 3 (1.2) | 2 (4.8) | 1 (6.3) | 0.265 |
| Aortic root (mm), median (IQR) | 37 (34–40) | 37 (34–40) | 35 (32–41) | 35 (32–37) | 0.007 |
| Aortic root index (mm/m2), median (IQR) | 20 (18–22) | 20 (18–22) | 19.5 (18–21) | 20 (19–21) | 0.700 |
| Ascending aorta (mm), median (IQR) | 39 (35–46) | 41 (34–46) | 38 (34–44.2) | 36 (35.5–39.5) | 0.005 |
| Ascending aorta index (mm/m2), median (IQR) | 21.2 (18.3–24.4) | 22.4 (19.4–25) | 20.8 (18.5–24.3) | 19.3 (18.2–23) | 0.296 |
| Aortopathy, n (%) | 101 (33.6) | 88 (35.9) | 12 (29.2) | 1 (6.3) | <0.001 |
| Ascending aortopathy, n (%) | 79 (26.2) | 67 (27.3) | 11 (26.8) | 1 (6.3) | 0.121 |
| Root aortopathy, n (%) | 5 (2.4) | 5 (3.2) | 0 (0) | 0 (0) | 0.374 |
| Extended aortopathy, n (%) | 17 (5.6) | 16 (6.5) | 1 (2.4) | 0 (0) | 0.218 |
| Baseline echocardiographic parameters . | |||||
|---|---|---|---|---|---|
| Overall . | Fused . | Two-sinus . | Partial fusion . | P-value . | |
| LVEDD (mm), median (IQR) | 50 (46–55) | 49 (46–55) | 50 (44–56.8) | 50 (46–54.5) | 0.921 |
| LVEDVi (ml/m2), median (IQR) | 68 (54.1–81.5) | 68 (53.2–82) | 66 (53–82) | 70 (61.7–83.7) | 0.812 |
| Cardiac mass index (g/m2), median (IQR) | 105 (88–130) | 104 (87–128) | 106 (89–142) | 131 (93–160.6) | 0.150 |
| RWT, median (IQR) | 0.42 (0.38–0.49) | 0.41 (0.37–0.48) | 0.43 (0.35–0.51) | 0.47 (0.41–0.55) | 0.301 |
| LVEF (%), median (IQR) | 60 (56–62) | 60 (56–62) | 60 (56–61) | 60 (56.5–64.5) | 0.675 |
| TAPSE (mm), median (IQR) | 23 (20–26) | 23 (20–26) | 22 (20–26) | 23 (20–25) | 0.777 |
| PAPs (mmHg), median (IQR) | 30 (25–35) | 30 (25–35) | 30 (25–35) | 28.5 (25–35) | 0.912 |
| Aortic stenosis, n (%) | 189 (62.6) | 149 (60.8) | 26 (61.9) | 14 (87.5) | 0.213 |
| Mild, n (%) | 32 (10.6) | 27 (11) | 3 (7.3) | 1 (6.3) | 0.664 |
| Moderate, n (%) | 59 (19.5) | 50 (20.4) | 5 (12.2) | 4 (25) | 0.314 |
| Severe, n (%) | 98 (32.5) | 67 (27.3) | 22 (52.4) | 9 (56.3) | 0.123 |
| Aortic regurgitation, n (%) | 263 (87) | 212 (86.5) | 36 (85.7) | 15 (93.8) | 0.624 |
| Mild, n (%) | 144 (47.7) | 115 (46.9) | 24 (58.5) | 5 (31.3) | 0.041 |
| Moderate, n (%) | 56 (18.5) | 38 (15.5) | 9 (22) | 9 (56.3) | <0.001 |
| Severe, n (%) | 63 (20.9) | 50 (20.4) | 11 (26.2) | 2 (12.5) | 0.398 |
| Combined aortic valve disease, n (%) | 150 (49.7) | 121 (49.4) | 16 (39) | 13 (81.3) | 0.023 |
| Severe combined aortic valve disease, n (%) | 6 (2) | 3 (1.2) | 2 (4.8) | 1 (6.3) | 0.265 |
| Aortic root (mm), median (IQR) | 37 (34–40) | 37 (34–40) | 35 (32–41) | 35 (32–37) | 0.007 |
| Aortic root index (mm/m2), median (IQR) | 20 (18–22) | 20 (18–22) | 19.5 (18–21) | 20 (19–21) | 0.700 |
| Ascending aorta (mm), median (IQR) | 39 (35–46) | 41 (34–46) | 38 (34–44.2) | 36 (35.5–39.5) | 0.005 |
| Ascending aorta index (mm/m2), median (IQR) | 21.2 (18.3–24.4) | 22.4 (19.4–25) | 20.8 (18.5–24.3) | 19.3 (18.2–23) | 0.296 |
| Aortopathy, n (%) | 101 (33.6) | 88 (35.9) | 12 (29.2) | 1 (6.3) | <0.001 |
| Ascending aortopathy, n (%) | 79 (26.2) | 67 (27.3) | 11 (26.8) | 1 (6.3) | 0.121 |
| Root aortopathy, n (%) | 5 (2.4) | 5 (3.2) | 0 (0) | 0 (0) | 0.374 |
| Extended aortopathy, n (%) | 17 (5.6) | 16 (6.5) | 1 (2.4) | 0 (0) | 0.218 |
LVEDD: left ventricle end-diastolic diameter; LVEDVi: left vetricle end-volume index; LVEF: left ventricle ejection fraction; RWT: relative wall thickness; TAPSE: tricuspid annular plane systolic excursion.
Values reported in bold if p < 0.05.
| Baseline echocardiographic parameters . | |||||
|---|---|---|---|---|---|
| Overall . | Fused . | Two-sinus . | Partial fusion . | P-value . | |
| LVEDD (mm), median (IQR) | 50 (46–55) | 49 (46–55) | 50 (44–56.8) | 50 (46–54.5) | 0.921 |
| LVEDVi (ml/m2), median (IQR) | 68 (54.1–81.5) | 68 (53.2–82) | 66 (53–82) | 70 (61.7–83.7) | 0.812 |
| Cardiac mass index (g/m2), median (IQR) | 105 (88–130) | 104 (87–128) | 106 (89–142) | 131 (93–160.6) | 0.150 |
| RWT, median (IQR) | 0.42 (0.38–0.49) | 0.41 (0.37–0.48) | 0.43 (0.35–0.51) | 0.47 (0.41–0.55) | 0.301 |
| LVEF (%), median (IQR) | 60 (56–62) | 60 (56–62) | 60 (56–61) | 60 (56.5–64.5) | 0.675 |
| TAPSE (mm), median (IQR) | 23 (20–26) | 23 (20–26) | 22 (20–26) | 23 (20–25) | 0.777 |
| PAPs (mmHg), median (IQR) | 30 (25–35) | 30 (25–35) | 30 (25–35) | 28.5 (25–35) | 0.912 |
| Aortic stenosis, n (%) | 189 (62.6) | 149 (60.8) | 26 (61.9) | 14 (87.5) | 0.213 |
| Mild, n (%) | 32 (10.6) | 27 (11) | 3 (7.3) | 1 (6.3) | 0.664 |
| Moderate, n (%) | 59 (19.5) | 50 (20.4) | 5 (12.2) | 4 (25) | 0.314 |
| Severe, n (%) | 98 (32.5) | 67 (27.3) | 22 (52.4) | 9 (56.3) | 0.123 |
| Aortic regurgitation, n (%) | 263 (87) | 212 (86.5) | 36 (85.7) | 15 (93.8) | 0.624 |
| Mild, n (%) | 144 (47.7) | 115 (46.9) | 24 (58.5) | 5 (31.3) | 0.041 |
| Moderate, n (%) | 56 (18.5) | 38 (15.5) | 9 (22) | 9 (56.3) | <0.001 |
| Severe, n (%) | 63 (20.9) | 50 (20.4) | 11 (26.2) | 2 (12.5) | 0.398 |
| Combined aortic valve disease, n (%) | 150 (49.7) | 121 (49.4) | 16 (39) | 13 (81.3) | 0.023 |
| Severe combined aortic valve disease, n (%) | 6 (2) | 3 (1.2) | 2 (4.8) | 1 (6.3) | 0.265 |
| Aortic root (mm), median (IQR) | 37 (34–40) | 37 (34–40) | 35 (32–41) | 35 (32–37) | 0.007 |
| Aortic root index (mm/m2), median (IQR) | 20 (18–22) | 20 (18–22) | 19.5 (18–21) | 20 (19–21) | 0.700 |
| Ascending aorta (mm), median (IQR) | 39 (35–46) | 41 (34–46) | 38 (34–44.2) | 36 (35.5–39.5) | 0.005 |
| Ascending aorta index (mm/m2), median (IQR) | 21.2 (18.3–24.4) | 22.4 (19.4–25) | 20.8 (18.5–24.3) | 19.3 (18.2–23) | 0.296 |
| Aortopathy, n (%) | 101 (33.6) | 88 (35.9) | 12 (29.2) | 1 (6.3) | <0.001 |
| Ascending aortopathy, n (%) | 79 (26.2) | 67 (27.3) | 11 (26.8) | 1 (6.3) | 0.121 |
| Root aortopathy, n (%) | 5 (2.4) | 5 (3.2) | 0 (0) | 0 (0) | 0.374 |
| Extended aortopathy, n (%) | 17 (5.6) | 16 (6.5) | 1 (2.4) | 0 (0) | 0.218 |
| Baseline echocardiographic parameters . | |||||
|---|---|---|---|---|---|
| Overall . | Fused . | Two-sinus . | Partial fusion . | P-value . | |
| LVEDD (mm), median (IQR) | 50 (46–55) | 49 (46–55) | 50 (44–56.8) | 50 (46–54.5) | 0.921 |
| LVEDVi (ml/m2), median (IQR) | 68 (54.1–81.5) | 68 (53.2–82) | 66 (53–82) | 70 (61.7–83.7) | 0.812 |
| Cardiac mass index (g/m2), median (IQR) | 105 (88–130) | 104 (87–128) | 106 (89–142) | 131 (93–160.6) | 0.150 |
| RWT, median (IQR) | 0.42 (0.38–0.49) | 0.41 (0.37–0.48) | 0.43 (0.35–0.51) | 0.47 (0.41–0.55) | 0.301 |
| LVEF (%), median (IQR) | 60 (56–62) | 60 (56–62) | 60 (56–61) | 60 (56.5–64.5) | 0.675 |
| TAPSE (mm), median (IQR) | 23 (20–26) | 23 (20–26) | 22 (20–26) | 23 (20–25) | 0.777 |
| PAPs (mmHg), median (IQR) | 30 (25–35) | 30 (25–35) | 30 (25–35) | 28.5 (25–35) | 0.912 |
| Aortic stenosis, n (%) | 189 (62.6) | 149 (60.8) | 26 (61.9) | 14 (87.5) | 0.213 |
| Mild, n (%) | 32 (10.6) | 27 (11) | 3 (7.3) | 1 (6.3) | 0.664 |
| Moderate, n (%) | 59 (19.5) | 50 (20.4) | 5 (12.2) | 4 (25) | 0.314 |
| Severe, n (%) | 98 (32.5) | 67 (27.3) | 22 (52.4) | 9 (56.3) | 0.123 |
| Aortic regurgitation, n (%) | 263 (87) | 212 (86.5) | 36 (85.7) | 15 (93.8) | 0.624 |
| Mild, n (%) | 144 (47.7) | 115 (46.9) | 24 (58.5) | 5 (31.3) | 0.041 |
| Moderate, n (%) | 56 (18.5) | 38 (15.5) | 9 (22) | 9 (56.3) | <0.001 |
| Severe, n (%) | 63 (20.9) | 50 (20.4) | 11 (26.2) | 2 (12.5) | 0.398 |
| Combined aortic valve disease, n (%) | 150 (49.7) | 121 (49.4) | 16 (39) | 13 (81.3) | 0.023 |
| Severe combined aortic valve disease, n (%) | 6 (2) | 3 (1.2) | 2 (4.8) | 1 (6.3) | 0.265 |
| Aortic root (mm), median (IQR) | 37 (34–40) | 37 (34–40) | 35 (32–41) | 35 (32–37) | 0.007 |
| Aortic root index (mm/m2), median (IQR) | 20 (18–22) | 20 (18–22) | 19.5 (18–21) | 20 (19–21) | 0.700 |
| Ascending aorta (mm), median (IQR) | 39 (35–46) | 41 (34–46) | 38 (34–44.2) | 36 (35.5–39.5) | 0.005 |
| Ascending aorta index (mm/m2), median (IQR) | 21.2 (18.3–24.4) | 22.4 (19.4–25) | 20.8 (18.5–24.3) | 19.3 (18.2–23) | 0.296 |
| Aortopathy, n (%) | 101 (33.6) | 88 (35.9) | 12 (29.2) | 1 (6.3) | <0.001 |
| Ascending aortopathy, n (%) | 79 (26.2) | 67 (27.3) | 11 (26.8) | 1 (6.3) | 0.121 |
| Root aortopathy, n (%) | 5 (2.4) | 5 (3.2) | 0 (0) | 0 (0) | 0.374 |
| Extended aortopathy, n (%) | 17 (5.6) | 16 (6.5) | 1 (2.4) | 0 (0) | 0.218 |
LVEDD: left ventricle end-diastolic diameter; LVEDVi: left vetricle end-volume index; LVEF: left ventricle ejection fraction; RWT: relative wall thickness; TAPSE: tricuspid annular plane systolic excursion.
Values reported in bold if p < 0.05.
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