Table 1: Open in new tab Baseline...

	All patients (n = 675)	Combined procedure (n = 317)	Isolated TVR procedure (n = 358)	P-value
Age, years	66.0 (54.0–74.0)	67.0 (58.0–73.4)	64.3 (49.0–74.0)	0.018
Male, n (%)	311 (46.1%)	142 (44.8%)	169 (47.2%)	0.582
BMI, kg/m²	25.4 (22.6–29.4)	25.0 (22.2–28.7)	25.7 (23.1–30.0)	0.007
Arterial hypertension, n (%)	390 (59.8%)	177 (57.3%)	213 (62.1%)	0.241
Diabetes mellitus, n (%)	146 (21.7%)	68 (21.5%)	78 (21.9%)	0.960
Dyslipidemia, n (%)	248 (38.4%)	114 (36.9%)	134 (39.9%)	0.485
COPD, n (%)	88 (13.1%)	43 (13.6%)	45 (12.7%)	0.843
Obesity, n (%)	165 (25.2%)	74 (23.9%)	91 (26.3%)	0.547
Peripheral artery disease, n (%)	60 (9.19%)	28 (9.06%)	32 (9.30%)	1.000
Preoperative pacemaker, n (%)	144 (22.1%)	73 (23.6%)	71 (20.6%)	0.410
Preoperative atrial fibrillation, n (%)	343 (50.8%)	167 (52.7%)	176 (49.2%)	0.403
Prior myocardial infarction, n (%)	58 (8.62%)	33 (10.4%)	25 (7.02%)	0.154
Redo surgery, n (%)	217 (33.9%)	93 (31.7%)	124 (35.7%)	0.327
Urgent surgery, n (%)	171 (25.4%)	75 (23.7%)	96 (26.9%)	0.382
Emergent surgery, n (%)	32 (4.75%)	8 (2.52%)	24 (6.72%)	0.017
NYHA class, n (%)				0.022
1	36 (5.55%)	9 (2.93%)	27 (7.89%)
2	222 (34.2%)	116 (37.8%)	106 (31.0%)
3	309 (47.6%)	142 (46.3%)	167 (48.8%)
4	82 (12.6%)	40 (13.0%)	42 (12.3%)
Preoperative IABP, n (%)	5 (0.78%)	4 (1.29%)	1 (0.30%)	0.202
Preoperative ECMO, n (%)	5 (0.78%)	4 (1.30%)	1 (0.30%)	0.201
GFR, mL/min/1.73 m²	63.9 (44.4–87.1)	61.4 (44.1–82.0)	67.5 (45.0–90.0)	0.113
Bilirubin, mg/dl	0.90 (0.58–1.39)	0.90 (0.59–1.35)	0.94 (0.58–1.40)	0.822
AST, U/l	31.0 (24.0–43.8)	30.0 (22.9–41.7)	32.0 (25.0–44.9)	0.057
MELDXi	10.7 (9.00–14.9)	11.0 (8.00–15.0)	10.1 (9.00–14.7)	0.336
Bioprosthesis size, mm	31.0 (29.0–33.0)	31.0 (29.0–33.0)	31.0 (31.0–33.0)	<0.001
Bioprosthesis type, n (%)				1.000
Carpentier-Edwards PERIMOUNT Magna Ease	239 (35.6%)	138 (43.8%)	101 (28.4%)
Medtronic Hancock	62 (9.24%)	36 (11.4%)	26 (7.30%)
Medtronic Mosaic	57 (8.49%)	23 (7.30%)	34 (9.55%)
Sorin Pericarbon Freedom	2 (0.30%)	2 (0.63%)	0 (0.00%)
St. Jude Medical Biocor	6 (0.89%)	4 (1.27%)	2 (0.56%)
St. Jude Medical Epic	302 (45.0%)	110 (34.9%)	192 (53.9%)
St. Jude Medical Trifecta	3 (0.45%)	2 (0.63%)	1 (0.28%)
Beating heart procedure	176 (33.4%)	66 (20.8%)	110 (52.4%)	<0.001
Concomittant procedure type, n (%)
Aortic valve replacement	69 (10.2%)	69 (21.8%)	0 (0.00%)	<0.001
Bentall procedure	4 (0.59%)	4 (1.26%)	0 (0.00%)	0.048
Mitral valve repair	31 (4.59%)	31 (9.78%)	0 (0.00%)	<0.001
Mitral valve replacement	104 (15.4%)	104 (32.8%)	0 (0.00%)	<0.001
Coronary artery bypass grafting	36 (5.33%)	36 (11.4%)	0 (0.00%)	<0.001
PFO/ASD closure	44 (6.52%)	44 (13.9%)	0 (0.00%)	<0.001
Other	170 (25.2%)	170 (53.6%)	0 (0.00%)	<0.001

All patients (n = 675)

Combined procedure (n = 317)

Isolated TVR procedure (n = 358)

P-value

Age, years

66.0 (54.0–74.0)

67.0 (58.0–73.4)

64.3 (49.0–74.0)

0.018

Male, n (%)

311 (46.1%)

142 (44.8%)

169 (47.2%)

0.582

BMI, kg/m²

25.4 (22.6–29.4)

25.0 (22.2–28.7)

25.7 (23.1–30.0)

0.007

Arterial hypertension, n (%)

390 (59.8%)

177 (57.3%)

213 (62.1%)

0.241

Diabetes mellitus, n (%)

146 (21.7%)

68 (21.5%)

78 (21.9%)

0.960

Dyslipidemia, n (%)

248 (38.4%)

114 (36.9%)

134 (39.9%)

0.485

COPD, n (%)

88 (13.1%)

43 (13.6%)

45 (12.7%)

0.843

Obesity, n (%)

165 (25.2%)

74 (23.9%)

91 (26.3%)

0.547

Peripheral artery disease, n (%)

60 (9.19%)

28 (9.06%)

32 (9.30%)

1.000

Preoperative pacemaker, n (%)

144 (22.1%)

73 (23.6%)

71 (20.6%)

0.410

Preoperative atrial fibrillation, n (%)

343 (50.8%)

167 (52.7%)

176 (49.2%)

0.403

Prior myocardial infarction, n (%)

58 (8.62%)

33 (10.4%)

25 (7.02%)

0.154

Redo surgery, n (%)

217 (33.9%)

93 (31.7%)

124 (35.7%)

0.327

Urgent surgery, n (%)

171 (25.4%)

75 (23.7%)

96 (26.9%)

0.382

Emergent surgery, n (%)

32 (4.75%)

8 (2.52%)

24 (6.72%)

0.017

NYHA class, n (%)

0.022

36 (5.55%)

9 (2.93%)

27 (7.89%)

222 (34.2%)

116 (37.8%)

106 (31.0%)

309 (47.6%)

142 (46.3%)

167 (48.8%)

82 (12.6%)

40 (13.0%)

42 (12.3%)

Preoperative IABP, n (%)

5 (0.78%)

4 (1.29%)

1 (0.30%)

0.202

Preoperative ECMO, n (%)

5 (0.78%)

4 (1.30%)

1 (0.30%)

0.201

GFR, mL/min/1.73 m²

63.9 (44.4–87.1)

61.4 (44.1–82.0)

67.5 (45.0–90.0)

0.113

Bilirubin, mg/dl

0.90 (0.58–1.39)

0.90 (0.59–1.35)

0.94 (0.58–1.40)

0.822

AST, U/l

31.0 (24.0–43.8)

30.0 (22.9–41.7)

32.0 (25.0–44.9)

0.057

MELDXi

10.7 (9.00–14.9)

11.0 (8.00–15.0)

10.1 (9.00–14.7)

0.336

Bioprosthesis size, mm

31.0 (29.0–33.0)

31.0 (31.0–33.0)

<0.001

Bioprosthesis type, n (%)

1.000

Carpentier-Edwards PERIMOUNT Magna Ease

239 (35.6%)

138 (43.8%)

101 (28.4%)

Medtronic Hancock

62 (9.24%)

36 (11.4%)

26 (7.30%)

Medtronic Mosaic

57 (8.49%)

23 (7.30%)

34 (9.55%)

Sorin Pericarbon Freedom

2 (0.30%)

2 (0.63%)

0 (0.00%)

St. Jude Medical Biocor

6 (0.89%)

4 (1.27%)

2 (0.56%)

St. Jude Medical Epic

302 (45.0%)

110 (34.9%)

192 (53.9%)

St. Jude Medical Trifecta

3 (0.45%)

2 (0.63%)

1 (0.28%)

Beating heart procedure

176 (33.4%)

66 (20.8%)

110 (52.4%)

<0.001

Concomittant procedure type, n (%)

Aortic valve replacement

69 (10.2%)

69 (21.8%)

0 (0.00%)

<0.001

Bentall procedure

4 (0.59%)

4 (1.26%)

0 (0.00%)

0.048

Mitral valve repair

31 (4.59%)

31 (9.78%)

0 (0.00%)

<0.001

Mitral valve replacement

104 (15.4%)

104 (32.8%)

0 (0.00%)

<0.001

Coronary artery bypass grafting

36 (5.33%)

36 (11.4%)

0 (0.00%)

<0.001

PFO/ASD closure

44 (6.52%)

44 (13.9%)

0 (0.00%)

<0.001

Other

170 (25.2%)

170 (53.6%)

0 (0.00%)

<0.001

	All patients (n = 675)	Combined procedure (n = 317)	Isolated TVR procedure (n = 358)	P-value
Age, years	66.0 (54.0–74.0)	67.0 (58.0–73.4)	64.3 (49.0–74.0)	0.018
Male, n (%)	311 (46.1%)	142 (44.8%)	169 (47.2%)	0.582
BMI, kg/m²	25.4 (22.6–29.4)	25.0 (22.2–28.7)	25.7 (23.1–30.0)	0.007
Arterial hypertension, n (%)	390 (59.8%)	177 (57.3%)	213 (62.1%)	0.241
Diabetes mellitus, n (%)	146 (21.7%)	68 (21.5%)	78 (21.9%)	0.960
Dyslipidemia, n (%)	248 (38.4%)	114 (36.9%)	134 (39.9%)	0.485
COPD, n (%)	88 (13.1%)	43 (13.6%)	45 (12.7%)	0.843
Obesity, n (%)	165 (25.2%)	74 (23.9%)	91 (26.3%)	0.547
Peripheral artery disease, n (%)	60 (9.19%)	28 (9.06%)	32 (9.30%)	1.000
Preoperative pacemaker, n (%)	144 (22.1%)	73 (23.6%)	71 (20.6%)	0.410
Preoperative atrial fibrillation, n (%)	343 (50.8%)	167 (52.7%)	176 (49.2%)	0.403
Prior myocardial infarction, n (%)	58 (8.62%)	33 (10.4%)	25 (7.02%)	0.154
Redo surgery, n (%)	217 (33.9%)	93 (31.7%)	124 (35.7%)	0.327
Urgent surgery, n (%)	171 (25.4%)	75 (23.7%)	96 (26.9%)	0.382
Emergent surgery, n (%)	32 (4.75%)	8 (2.52%)	24 (6.72%)	0.017
NYHA class, n (%)				0.022
1	36 (5.55%)	9 (2.93%)	27 (7.89%)
2	222 (34.2%)	116 (37.8%)	106 (31.0%)
3	309 (47.6%)	142 (46.3%)	167 (48.8%)
4	82 (12.6%)	40 (13.0%)	42 (12.3%)
Preoperative IABP, n (%)	5 (0.78%)	4 (1.29%)	1 (0.30%)	0.202
Preoperative ECMO, n (%)	5 (0.78%)	4 (1.30%)	1 (0.30%)	0.201
GFR, mL/min/1.73 m²	63.9 (44.4–87.1)	61.4 (44.1–82.0)	67.5 (45.0–90.0)	0.113
Bilirubin, mg/dl	0.90 (0.58–1.39)	0.90 (0.59–1.35)	0.94 (0.58–1.40)	0.822
AST, U/l	31.0 (24.0–43.8)	30.0 (22.9–41.7)	32.0 (25.0–44.9)	0.057
MELDXi	10.7 (9.00–14.9)	11.0 (8.00–15.0)	10.1 (9.00–14.7)	0.336
Bioprosthesis size, mm	31.0 (29.0–33.0)	31.0 (29.0–33.0)	31.0 (31.0–33.0)	<0.001
Bioprosthesis type, n (%)				1.000
Carpentier-Edwards PERIMOUNT Magna Ease	239 (35.6%)	138 (43.8%)	101 (28.4%)
Medtronic Hancock	62 (9.24%)	36 (11.4%)	26 (7.30%)
Medtronic Mosaic	57 (8.49%)	23 (7.30%)	34 (9.55%)
Sorin Pericarbon Freedom	2 (0.30%)	2 (0.63%)	0 (0.00%)
St. Jude Medical Biocor	6 (0.89%)	4 (1.27%)	2 (0.56%)
St. Jude Medical Epic	302 (45.0%)	110 (34.9%)	192 (53.9%)
St. Jude Medical Trifecta	3 (0.45%)	2 (0.63%)	1 (0.28%)
Beating heart procedure	176 (33.4%)	66 (20.8%)	110 (52.4%)	<0.001
Concomittant procedure type, n (%)
Aortic valve replacement	69 (10.2%)	69 (21.8%)	0 (0.00%)	<0.001
Bentall procedure	4 (0.59%)	4 (1.26%)	0 (0.00%)	0.048
Mitral valve repair	31 (4.59%)	31 (9.78%)	0 (0.00%)	<0.001
Mitral valve replacement	104 (15.4%)	104 (32.8%)	0 (0.00%)	<0.001
Coronary artery bypass grafting	36 (5.33%)	36 (11.4%)	0 (0.00%)	<0.001
PFO/ASD closure	44 (6.52%)	44 (13.9%)	0 (0.00%)	<0.001
Other	170 (25.2%)	170 (53.6%)	0 (0.00%)	<0.001

All patients (n = 675)

Combined procedure (n = 317)

Isolated TVR procedure (n = 358)

P-value

Age, years

66.0 (54.0–74.0)

67.0 (58.0–73.4)

64.3 (49.0–74.0)

0.018

Male, n (%)

311 (46.1%)

142 (44.8%)

169 (47.2%)

0.582

BMI, kg/m²

25.4 (22.6–29.4)

25.0 (22.2–28.7)

25.7 (23.1–30.0)

0.007

Arterial hypertension, n (%)

390 (59.8%)

177 (57.3%)

213 (62.1%)

0.241

Diabetes mellitus, n (%)

146 (21.7%)

68 (21.5%)

78 (21.9%)

0.960

Dyslipidemia, n (%)

248 (38.4%)

114 (36.9%)

134 (39.9%)

0.485

COPD, n (%)

88 (13.1%)

43 (13.6%)

45 (12.7%)

0.843

Obesity, n (%)

165 (25.2%)

74 (23.9%)

91 (26.3%)

0.547

Peripheral artery disease, n (%)

60 (9.19%)

28 (9.06%)

32 (9.30%)

1.000

Preoperative pacemaker, n (%)

144 (22.1%)

73 (23.6%)

71 (20.6%)

0.410

Preoperative atrial fibrillation, n (%)

343 (50.8%)

167 (52.7%)

176 (49.2%)

0.403

Prior myocardial infarction, n (%)

58 (8.62%)

33 (10.4%)

25 (7.02%)

0.154

Redo surgery, n (%)

217 (33.9%)

93 (31.7%)

124 (35.7%)

0.327

Urgent surgery, n (%)

171 (25.4%)

75 (23.7%)

96 (26.9%)

0.382

Emergent surgery, n (%)

32 (4.75%)

8 (2.52%)

24 (6.72%)

0.017

NYHA class, n (%)

0.022

36 (5.55%)

9 (2.93%)

27 (7.89%)

222 (34.2%)

116 (37.8%)

106 (31.0%)

309 (47.6%)

142 (46.3%)

167 (48.8%)

82 (12.6%)

40 (13.0%)

42 (12.3%)

Preoperative IABP, n (%)

5 (0.78%)

4 (1.29%)

1 (0.30%)

0.202

Preoperative ECMO, n (%)

5 (0.78%)

4 (1.30%)

1 (0.30%)

0.201

GFR, mL/min/1.73 m²

63.9 (44.4–87.1)

61.4 (44.1–82.0)

67.5 (45.0–90.0)

0.113

Bilirubin, mg/dl

0.90 (0.58–1.39)

0.90 (0.59–1.35)

0.94 (0.58–1.40)

0.822

AST, U/l

31.0 (24.0–43.8)

30.0 (22.9–41.7)

32.0 (25.0–44.9)

0.057

MELDXi

10.7 (9.00–14.9)

11.0 (8.00–15.0)

10.1 (9.00–14.7)

0.336

Bioprosthesis size, mm

31.0 (29.0–33.0)

31.0 (31.0–33.0)

<0.001

Bioprosthesis type, n (%)

1.000

Carpentier-Edwards PERIMOUNT Magna Ease

239 (35.6%)

138 (43.8%)

101 (28.4%)

Medtronic Hancock

62 (9.24%)

36 (11.4%)

26 (7.30%)

Medtronic Mosaic

57 (8.49%)

23 (7.30%)

34 (9.55%)

Sorin Pericarbon Freedom

2 (0.30%)

2 (0.63%)

0 (0.00%)

St. Jude Medical Biocor

6 (0.89%)

4 (1.27%)

2 (0.56%)

St. Jude Medical Epic

302 (45.0%)

110 (34.9%)

192 (53.9%)

St. Jude Medical Trifecta

3 (0.45%)

2 (0.63%)

1 (0.28%)

Beating heart procedure

176 (33.4%)

66 (20.8%)

110 (52.4%)

<0.001

Concomittant procedure type, n (%)

Aortic valve replacement

69 (10.2%)

69 (21.8%)

0 (0.00%)

<0.001

Bentall procedure

4 (0.59%)

4 (1.26%)

0 (0.00%)

0.048

Mitral valve repair

31 (4.59%)

31 (9.78%)

0 (0.00%)

<0.001

Mitral valve replacement

104 (15.4%)

104 (32.8%)

0 (0.00%)

<0.001

Coronary artery bypass grafting

36 (5.33%)

36 (11.4%)

0 (0.00%)

<0.001

PFO/ASD closure

44 (6.52%)

44 (13.9%)

0 (0.00%)

<0.001

Other

170 (25.2%)

170 (53.6%)

0 (0.00%)

<0.001

Table 1:

Open in new tab

Baseline demographics and procedural details

	All patients (n = 675)	Combined procedure (n = 317)	Isolated TVR procedure (n = 358)	P-value
Age, years	66.0 (54.0–74.0)	67.0 (58.0–73.4)	64.3 (49.0–74.0)	0.018
Male, n (%)	311 (46.1%)	142 (44.8%)	169 (47.2%)	0.582
BMI, kg/m²	25.4 (22.6–29.4)	25.0 (22.2–28.7)	25.7 (23.1–30.0)	0.007
Arterial hypertension, n (%)	390 (59.8%)	177 (57.3%)	213 (62.1%)	0.241
Diabetes mellitus, n (%)	146 (21.7%)	68 (21.5%)	78 (21.9%)	0.960
Dyslipidemia, n (%)	248 (38.4%)	114 (36.9%)	134 (39.9%)	0.485
COPD, n (%)	88 (13.1%)	43 (13.6%)	45 (12.7%)	0.843
Obesity, n (%)	165 (25.2%)	74 (23.9%)	91 (26.3%)	0.547
Peripheral artery disease, n (%)	60 (9.19%)	28 (9.06%)	32 (9.30%)	1.000
Preoperative pacemaker, n (%)	144 (22.1%)	73 (23.6%)	71 (20.6%)	0.410
Preoperative atrial fibrillation, n (%)	343 (50.8%)	167 (52.7%)	176 (49.2%)	0.403
Prior myocardial infarction, n (%)	58 (8.62%)	33 (10.4%)	25 (7.02%)	0.154
Redo surgery, n (%)	217 (33.9%)	93 (31.7%)	124 (35.7%)	0.327
Urgent surgery, n (%)	171 (25.4%)	75 (23.7%)	96 (26.9%)	0.382
Emergent surgery, n (%)	32 (4.75%)	8 (2.52%)	24 (6.72%)	0.017
NYHA class, n (%)				0.022
1	36 (5.55%)	9 (2.93%)	27 (7.89%)
2	222 (34.2%)	116 (37.8%)	106 (31.0%)
3	309 (47.6%)	142 (46.3%)	167 (48.8%)
4	82 (12.6%)	40 (13.0%)	42 (12.3%)
Preoperative IABP, n (%)	5 (0.78%)	4 (1.29%)	1 (0.30%)	0.202
Preoperative ECMO, n (%)	5 (0.78%)	4 (1.30%)	1 (0.30%)	0.201
GFR, mL/min/1.73 m²	63.9 (44.4–87.1)	61.4 (44.1–82.0)	67.5 (45.0–90.0)	0.113
Bilirubin, mg/dl	0.90 (0.58–1.39)	0.90 (0.59–1.35)	0.94 (0.58–1.40)	0.822
AST, U/l	31.0 (24.0–43.8)	30.0 (22.9–41.7)	32.0 (25.0–44.9)	0.057
MELDXi	10.7 (9.00–14.9)	11.0 (8.00–15.0)	10.1 (9.00–14.7)	0.336
Bioprosthesis size, mm	31.0 (29.0–33.0)	31.0 (29.0–33.0)	31.0 (31.0–33.0)	<0.001
Bioprosthesis type, n (%)				1.000
Carpentier-Edwards PERIMOUNT Magna Ease	239 (35.6%)	138 (43.8%)	101 (28.4%)
Medtronic Hancock	62 (9.24%)	36 (11.4%)	26 (7.30%)
Medtronic Mosaic	57 (8.49%)	23 (7.30%)	34 (9.55%)
Sorin Pericarbon Freedom	2 (0.30%)	2 (0.63%)	0 (0.00%)
St. Jude Medical Biocor	6 (0.89%)	4 (1.27%)	2 (0.56%)
St. Jude Medical Epic	302 (45.0%)	110 (34.9%)	192 (53.9%)
St. Jude Medical Trifecta	3 (0.45%)	2 (0.63%)	1 (0.28%)
Beating heart procedure	176 (33.4%)	66 (20.8%)	110 (52.4%)	<0.001
Concomittant procedure type, n (%)
Aortic valve replacement	69 (10.2%)	69 (21.8%)	0 (0.00%)	<0.001
Bentall procedure	4 (0.59%)	4 (1.26%)	0 (0.00%)	0.048
Mitral valve repair	31 (4.59%)	31 (9.78%)	0 (0.00%)	<0.001
Mitral valve replacement	104 (15.4%)	104 (32.8%)	0 (0.00%)	<0.001
Coronary artery bypass grafting	36 (5.33%)	36 (11.4%)	0 (0.00%)	<0.001
PFO/ASD closure	44 (6.52%)	44 (13.9%)	0 (0.00%)	<0.001
Other	170 (25.2%)	170 (53.6%)	0 (0.00%)	<0.001

	All patients (n = 675)	Combined procedure (n = 317)	Isolated TVR procedure (n = 358)	P-value
Age, years	66.0 (54.0–74.0)	67.0 (58.0–73.4)	64.3 (49.0–74.0)	0.018
Male, n (%)	311 (46.1%)	142 (44.8%)	169 (47.2%)	0.582
BMI, kg/m²	25.4 (22.6–29.4)	25.0 (22.2–28.7)	25.7 (23.1–30.0)	0.007
Arterial hypertension, n (%)	390 (59.8%)	177 (57.3%)	213 (62.1%)	0.241
Diabetes mellitus, n (%)	146 (21.7%)	68 (21.5%)	78 (21.9%)	0.960
Dyslipidemia, n (%)	248 (38.4%)	114 (36.9%)	134 (39.9%)	0.485
COPD, n (%)	88 (13.1%)	43 (13.6%)	45 (12.7%)	0.843
Obesity, n (%)	165 (25.2%)	74 (23.9%)	91 (26.3%)	0.547
Peripheral artery disease, n (%)	60 (9.19%)	28 (9.06%)	32 (9.30%)	1.000
Preoperative pacemaker, n (%)	144 (22.1%)	73 (23.6%)	71 (20.6%)	0.410
Preoperative atrial fibrillation, n (%)	343 (50.8%)	167 (52.7%)	176 (49.2%)	0.403
Prior myocardial infarction, n (%)	58 (8.62%)	33 (10.4%)	25 (7.02%)	0.154
Redo surgery, n (%)	217 (33.9%)	93 (31.7%)	124 (35.7%)	0.327
Urgent surgery, n (%)	171 (25.4%)	75 (23.7%)	96 (26.9%)	0.382
Emergent surgery, n (%)	32 (4.75%)	8 (2.52%)	24 (6.72%)	0.017
NYHA class, n (%)				0.022
1	36 (5.55%)	9 (2.93%)	27 (7.89%)
2	222 (34.2%)	116 (37.8%)	106 (31.0%)
3	309 (47.6%)	142 (46.3%)	167 (48.8%)
4	82 (12.6%)	40 (13.0%)	42 (12.3%)
Preoperative IABP, n (%)	5 (0.78%)	4 (1.29%)	1 (0.30%)	0.202
Preoperative ECMO, n (%)	5 (0.78%)	4 (1.30%)	1 (0.30%)	0.201
GFR, mL/min/1.73 m²	63.9 (44.4–87.1)	61.4 (44.1–82.0)	67.5 (45.0–90.0)	0.113
Bilirubin, mg/dl	0.90 (0.58–1.39)	0.90 (0.59–1.35)	0.94 (0.58–1.40)	0.822
AST, U/l	31.0 (24.0–43.8)	30.0 (22.9–41.7)	32.0 (25.0–44.9)	0.057
MELDXi	10.7 (9.00–14.9)	11.0 (8.00–15.0)	10.1 (9.00–14.7)	0.336
Bioprosthesis size, mm	31.0 (29.0–33.0)	31.0 (29.0–33.0)	31.0 (31.0–33.0)	<0.001
Bioprosthesis type, n (%)				1.000
Carpentier-Edwards PERIMOUNT Magna Ease	239 (35.6%)	138 (43.8%)	101 (28.4%)
Medtronic Hancock	62 (9.24%)	36 (11.4%)	26 (7.30%)
Medtronic Mosaic	57 (8.49%)	23 (7.30%)	34 (9.55%)
Sorin Pericarbon Freedom	2 (0.30%)	2 (0.63%)	0 (0.00%)
St. Jude Medical Biocor	6 (0.89%)	4 (1.27%)	2 (0.56%)
St. Jude Medical Epic	302 (45.0%)	110 (34.9%)	192 (53.9%)
St. Jude Medical Trifecta	3 (0.45%)	2 (0.63%)	1 (0.28%)
Beating heart procedure	176 (33.4%)	66 (20.8%)	110 (52.4%)	<0.001
Concomittant procedure type, n (%)
Aortic valve replacement	69 (10.2%)	69 (21.8%)	0 (0.00%)	<0.001
Bentall procedure	4 (0.59%)	4 (1.26%)	0 (0.00%)	0.048
Mitral valve repair	31 (4.59%)	31 (9.78%)	0 (0.00%)	<0.001
Mitral valve replacement	104 (15.4%)	104 (32.8%)	0 (0.00%)	<0.001
Coronary artery bypass grafting	36 (5.33%)	36 (11.4%)	0 (0.00%)	<0.001
PFO/ASD closure	44 (6.52%)	44 (13.9%)	0 (0.00%)	<0.001
Other	170 (25.2%)	170 (53.6%)	0 (0.00%)	<0.001

BMI: body mass index; COPD: chronic obstructive pulmonary disease; ECMO: extracorporeal membrane oxygenation; IABP: intra-aortic balloon pump; NYHA: New York Heart Association; PFO: patent foramen ovale.

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