Table 2
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Predictive variables used in these 15 prediction models.

 Prediction models (N = 15)
no.%
Patient-related:
  Performance status (ECOG or KPS)533.3
  Age213.3
  Diastolic BP213.3
  Significant weight loss213.3
  BMI213.3
  Psychological stress or acute disease16.7
  DPYD status16.7
  5-FU-DR16.7
  Social support16.7
  Fluid consumption16.7
  Sex16.7
Disease-related:
  Cancer stage320.0
  Cancer type320.0
Treatment-related:
  MAX2 toxicity score533.3
  Number of chemotherapies426.7
  Dose of chemotherapy320.0
  Poly/mono chemotherapy213.3
  Use of particular chemotherapy16.7
  Time from diagnosis to first chemotherapy16.7
  Treatment duration16.7
Geriatric assessment:
 Functioning
  ALD or IADL640.0
  Limitation in walking213.3
  Falls number213.3
  Grip strength16.7
  Social activities16.7
  Hearing impairment16.7
 Cognition
  MMS213.3
  Limitation of daily life due to dementia16.7
  Ability to obey command16.7
 Nutrition
  MNA213.3
  CONUT16.7
 Others
  CCI or co-morbidities213.3
  Health perception16.7
Laboratory:
  Creatinine clearance426.7
  Haemoglobin426.7
  Serum albumin320.0
  Lactate dehydrogenase320.0
  White cell count16.7
  Platelet count16.7
  Liver function16.7
  C-reactive protein16.7
  Protein16.7
 Prediction models (N = 15)
no.%
Patient-related:
  Performance status (ECOG or KPS)533.3
  Age213.3
  Diastolic BP213.3
  Significant weight loss213.3
  BMI213.3
  Psychological stress or acute disease16.7
  DPYD status16.7
  5-FU-DR16.7
  Social support16.7
  Fluid consumption16.7
  Sex16.7
Disease-related:
  Cancer stage320.0
  Cancer type320.0
Treatment-related:
  MAX2 toxicity score533.3
  Number of chemotherapies426.7
  Dose of chemotherapy320.0
  Poly/mono chemotherapy213.3
  Use of particular chemotherapy16.7
  Time from diagnosis to first chemotherapy16.7
  Treatment duration16.7
Geriatric assessment:
 Functioning
  ALD or IADL640.0
  Limitation in walking213.3
  Falls number213.3
  Grip strength16.7
  Social activities16.7
  Hearing impairment16.7
 Cognition
  MMS213.3
  Limitation of daily life due to dementia16.7
  Ability to obey command16.7
 Nutrition
  MNA213.3
  CONUT16.7
 Others
  CCI or co-morbidities213.3
  Health perception16.7
Laboratory:
  Creatinine clearance426.7
  Haemoglobin426.7
  Serum albumin320.0
  Lactate dehydrogenase320.0
  White cell count16.7
  Platelet count16.7
  Liver function16.7
  C-reactive protein16.7
  Protein16.7

Abbreviations: ADL, activities of daily living. BMI, body mass index. BP, blood pressure. CCI, Charlson comorbidity score. CONUT, controlling nutritional status. DPYD, dihydropyrimidine dehydrogenase, ECOG, eastern cooperative oncology group. 5-FU-DR, 5-fluorouracil degradation rate. IADL, instrumental activities of daily living. KPS, Karnofsky performance scale. MNA, mini nutritional assessment. MMS, Mini-mental state.

Table 2
Open in new tab

Predictive variables used in these 15 prediction models.

 Prediction models (N = 15)
no.%
Patient-related:
  Performance status (ECOG or KPS)533.3
  Age213.3
  Diastolic BP213.3
  Significant weight loss213.3
  BMI213.3
  Psychological stress or acute disease16.7
  DPYD status16.7
  5-FU-DR16.7
  Social support16.7
  Fluid consumption16.7
  Sex16.7
Disease-related:
  Cancer stage320.0
  Cancer type320.0
Treatment-related:
  MAX2 toxicity score533.3
  Number of chemotherapies426.7
  Dose of chemotherapy320.0
  Poly/mono chemotherapy213.3
  Use of particular chemotherapy16.7
  Time from diagnosis to first chemotherapy16.7
  Treatment duration16.7
Geriatric assessment:
 Functioning
  ALD or IADL640.0
  Limitation in walking213.3
  Falls number213.3
  Grip strength16.7
  Social activities16.7
  Hearing impairment16.7
 Cognition
  MMS213.3
  Limitation of daily life due to dementia16.7
  Ability to obey command16.7
 Nutrition
  MNA213.3
  CONUT16.7
 Others
  CCI or co-morbidities213.3
  Health perception16.7
Laboratory:
  Creatinine clearance426.7
  Haemoglobin426.7
  Serum albumin320.0
  Lactate dehydrogenase320.0
  White cell count16.7
  Platelet count16.7
  Liver function16.7
  C-reactive protein16.7
  Protein16.7
 Prediction models (N = 15)
no.%
Patient-related:
  Performance status (ECOG or KPS)533.3
  Age213.3
  Diastolic BP213.3
  Significant weight loss213.3
  BMI213.3
  Psychological stress or acute disease16.7
  DPYD status16.7
  5-FU-DR16.7
  Social support16.7
  Fluid consumption16.7
  Sex16.7
Disease-related:
  Cancer stage320.0
  Cancer type320.0
Treatment-related:
  MAX2 toxicity score533.3
  Number of chemotherapies426.7
  Dose of chemotherapy320.0
  Poly/mono chemotherapy213.3
  Use of particular chemotherapy16.7
  Time from diagnosis to first chemotherapy16.7
  Treatment duration16.7
Geriatric assessment:
 Functioning
  ALD or IADL640.0
  Limitation in walking213.3
  Falls number213.3
  Grip strength16.7
  Social activities16.7
  Hearing impairment16.7
 Cognition
  MMS213.3
  Limitation of daily life due to dementia16.7
  Ability to obey command16.7
 Nutrition
  MNA213.3
  CONUT16.7
 Others
  CCI or co-morbidities213.3
  Health perception16.7
Laboratory:
  Creatinine clearance426.7
  Haemoglobin426.7
  Serum albumin320.0
  Lactate dehydrogenase320.0
  White cell count16.7
  Platelet count16.7
  Liver function16.7
  C-reactive protein16.7
  Protein16.7

Abbreviations: ADL, activities of daily living. BMI, body mass index. BP, blood pressure. CCI, Charlson comorbidity score. CONUT, controlling nutritional status. DPYD, dihydropyrimidine dehydrogenase, ECOG, eastern cooperative oncology group. 5-FU-DR, 5-fluorouracil degradation rate. IADL, instrumental activities of daily living. KPS, Karnofsky performance scale. MNA, mini nutritional assessment. MMS, Mini-mental state.

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