HR of all-cause deaths and cardiovascular events in patients with type 2 diabetes based on BMI change from baseline to the end date
| Outcome . | HR . | 95% CI . | |
|---|---|---|---|
| All-cause deaths | Lean to lean | 4.825a | 4.320, 5.389 |
| Lean to non-lean | 0.996 | 0.764, 1.300 | |
| Non-lean to lean | 1.999a | 1.686, 2.369 | |
| Non-lean to non-lean | Reference | ||
| CVD (I00-I99) | Lean to lean | 1.464a | 1.353, 1.584 |
| Lean to non-lean | 0.817a | 0.732, 0.913 | |
| Non-lean to lean | 0.980 | 0.885, 1.086 | |
| Non-lean to non-lean | Reference | ||
| CHD (I20-I25) | Lean to lean | 1.770a | 1.563, 2.004 |
| Lean to non-lean | 0.796a | 0.655, 0.967 | |
| Non-lean to lean | 1.097 | 0.931, 1.291 | |
| Non-lean to non-lean | Reference | ||
| HF (I50) | Lean to lean | 2.150a | 1.846, 2.504 |
| Lean to non-lean | 1.120 | 0.894, 1.402 | |
| Non-lean to lean | 1.862a | 1.574, 2.203 | |
| Non-lean to non-lean | Reference | ||
| Stroke (I60-I64) | Lean to lean | 1.849a | 1.522, 2.247 |
| Lean to non-lean | 0.717 | 0.511, 1.006 | |
| Non-lean to lean | 1.089 | 0.845, 1.404 | |
| Non-lean to non-lean | Reference | ||
| Hemorrhagic stroke (I60-I62) | Lean to lean | 1.784a | 1.202, 2.647 |
| Lean to non-lean | 0.725 | 0.375, 1.400 | |
| Non-lean to lean | 1.638a | 1.070, 2.506 | |
| Non-lean to non-lean | Reference | ||
| Ischemic stroke (I63) | Lean to lean | 1.984a | 1.581, 2.490 |
| Lean to non-lean | 0.807 | 0.547, 1.188 | |
| Non-lean to lean | 0.919 | 0.663, 1.273 | |
| Non-lean to non-lean | Reference | ||
| Outcome . | HR . | 95% CI . | |
|---|---|---|---|
| All-cause deaths | Lean to lean | 4.825a | 4.320, 5.389 |
| Lean to non-lean | 0.996 | 0.764, 1.300 | |
| Non-lean to lean | 1.999a | 1.686, 2.369 | |
| Non-lean to non-lean | Reference | ||
| CVD (I00-I99) | Lean to lean | 1.464a | 1.353, 1.584 |
| Lean to non-lean | 0.817a | 0.732, 0.913 | |
| Non-lean to lean | 0.980 | 0.885, 1.086 | |
| Non-lean to non-lean | Reference | ||
| CHD (I20-I25) | Lean to lean | 1.770a | 1.563, 2.004 |
| Lean to non-lean | 0.796a | 0.655, 0.967 | |
| Non-lean to lean | 1.097 | 0.931, 1.291 | |
| Non-lean to non-lean | Reference | ||
| HF (I50) | Lean to lean | 2.150a | 1.846, 2.504 |
| Lean to non-lean | 1.120 | 0.894, 1.402 | |
| Non-lean to lean | 1.862a | 1.574, 2.203 | |
| Non-lean to non-lean | Reference | ||
| Stroke (I60-I64) | Lean to lean | 1.849a | 1.522, 2.247 |
| Lean to non-lean | 0.717 | 0.511, 1.006 | |
| Non-lean to lean | 1.089 | 0.845, 1.404 | |
| Non-lean to non-lean | Reference | ||
| Hemorrhagic stroke (I60-I62) | Lean to lean | 1.784a | 1.202, 2.647 |
| Lean to non-lean | 0.725 | 0.375, 1.400 | |
| Non-lean to lean | 1.638a | 1.070, 2.506 | |
| Non-lean to non-lean | Reference | ||
| Ischemic stroke (I63) | Lean to lean | 1.984a | 1.581, 2.490 |
| Lean to non-lean | 0.807 | 0.547, 1.188 | |
| Non-lean to lean | 0.919 | 0.663, 1.273 | |
| Non-lean to non-lean | Reference | ||
All models were adjusted for age, sex, location of residence, income level, smoking status, alcohol consumption, physical activity, use of medication, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.
Abbreviations: BMI, body mass index; CI, confidence interval; CHD, coronary heart disease; CVD, cardiovascular disease; HF, heart failure; HR, hazard ratio.
aStatistically significant (P < .05).
HR of all-cause deaths and cardiovascular events in patients with type 2 diabetes based on BMI change from baseline to the end date
| Outcome . | HR . | 95% CI . | |
|---|---|---|---|
| All-cause deaths | Lean to lean | 4.825a | 4.320, 5.389 |
| Lean to non-lean | 0.996 | 0.764, 1.300 | |
| Non-lean to lean | 1.999a | 1.686, 2.369 | |
| Non-lean to non-lean | Reference | ||
| CVD (I00-I99) | Lean to lean | 1.464a | 1.353, 1.584 |
| Lean to non-lean | 0.817a | 0.732, 0.913 | |
| Non-lean to lean | 0.980 | 0.885, 1.086 | |
| Non-lean to non-lean | Reference | ||
| CHD (I20-I25) | Lean to lean | 1.770a | 1.563, 2.004 |
| Lean to non-lean | 0.796a | 0.655, 0.967 | |
| Non-lean to lean | 1.097 | 0.931, 1.291 | |
| Non-lean to non-lean | Reference | ||
| HF (I50) | Lean to lean | 2.150a | 1.846, 2.504 |
| Lean to non-lean | 1.120 | 0.894, 1.402 | |
| Non-lean to lean | 1.862a | 1.574, 2.203 | |
| Non-lean to non-lean | Reference | ||
| Stroke (I60-I64) | Lean to lean | 1.849a | 1.522, 2.247 |
| Lean to non-lean | 0.717 | 0.511, 1.006 | |
| Non-lean to lean | 1.089 | 0.845, 1.404 | |
| Non-lean to non-lean | Reference | ||
| Hemorrhagic stroke (I60-I62) | Lean to lean | 1.784a | 1.202, 2.647 |
| Lean to non-lean | 0.725 | 0.375, 1.400 | |
| Non-lean to lean | 1.638a | 1.070, 2.506 | |
| Non-lean to non-lean | Reference | ||
| Ischemic stroke (I63) | Lean to lean | 1.984a | 1.581, 2.490 |
| Lean to non-lean | 0.807 | 0.547, 1.188 | |
| Non-lean to lean | 0.919 | 0.663, 1.273 | |
| Non-lean to non-lean | Reference | ||
| Outcome . | HR . | 95% CI . | |
|---|---|---|---|
| All-cause deaths | Lean to lean | 4.825a | 4.320, 5.389 |
| Lean to non-lean | 0.996 | 0.764, 1.300 | |
| Non-lean to lean | 1.999a | 1.686, 2.369 | |
| Non-lean to non-lean | Reference | ||
| CVD (I00-I99) | Lean to lean | 1.464a | 1.353, 1.584 |
| Lean to non-lean | 0.817a | 0.732, 0.913 | |
| Non-lean to lean | 0.980 | 0.885, 1.086 | |
| Non-lean to non-lean | Reference | ||
| CHD (I20-I25) | Lean to lean | 1.770a | 1.563, 2.004 |
| Lean to non-lean | 0.796a | 0.655, 0.967 | |
| Non-lean to lean | 1.097 | 0.931, 1.291 | |
| Non-lean to non-lean | Reference | ||
| HF (I50) | Lean to lean | 2.150a | 1.846, 2.504 |
| Lean to non-lean | 1.120 | 0.894, 1.402 | |
| Non-lean to lean | 1.862a | 1.574, 2.203 | |
| Non-lean to non-lean | Reference | ||
| Stroke (I60-I64) | Lean to lean | 1.849a | 1.522, 2.247 |
| Lean to non-lean | 0.717 | 0.511, 1.006 | |
| Non-lean to lean | 1.089 | 0.845, 1.404 | |
| Non-lean to non-lean | Reference | ||
| Hemorrhagic stroke (I60-I62) | Lean to lean | 1.784a | 1.202, 2.647 |
| Lean to non-lean | 0.725 | 0.375, 1.400 | |
| Non-lean to lean | 1.638a | 1.070, 2.506 | |
| Non-lean to non-lean | Reference | ||
| Ischemic stroke (I63) | Lean to lean | 1.984a | 1.581, 2.490 |
| Lean to non-lean | 0.807 | 0.547, 1.188 | |
| Non-lean to lean | 0.919 | 0.663, 1.273 | |
| Non-lean to non-lean | Reference | ||
All models were adjusted for age, sex, location of residence, income level, smoking status, alcohol consumption, physical activity, use of medication, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.
Abbreviations: BMI, body mass index; CI, confidence interval; CHD, coronary heart disease; CVD, cardiovascular disease; HF, heart failure; HR, hazard ratio.
aStatistically significant (P < .05).
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