Table 2: Open in new tab Summary of...

Table 2:

Summary of relative advantages and limitations of each imaging-based biomechanics approach

Parameters	Advantages	Limitations
Strain-based parameters	• Simple, feasible computation • Versatile imaging modalities for measurement	• Does not incorporate effect of blood pressure • Paucity of evidence as independent predictor of adverse aortic events
Stiffness-based parameters	• Incorporates effect of blood pressure • Preliminary evidence suggests parameters predictive of adverse aortic events	• Lack of standardization definitions • Reliable non-invasive estimation of central blood pressure remains challenging
Computational modelling	• High-resolution analysis of aortic wall response to haemodynamic stresses • Provides mechanistic model of aortic biomechanics	• Requires significant modelling assumptions • High computational costs • Technical engineering expertise required to develop and run models

Parameters	Advantages	Limitations
Strain-based parameters	• Simple, feasible computation • Versatile imaging modalities for measurement	• Does not incorporate effect of blood pressure • Paucity of evidence as independent predictor of adverse aortic events
Stiffness-based parameters	• Incorporates effect of blood pressure • Preliminary evidence suggests parameters predictive of adverse aortic events	• Lack of standardization definitions • Reliable non-invasive estimation of central blood pressure remains challenging
Computational modelling	• High-resolution analysis of aortic wall response to haemodynamic stresses • Provides mechanistic model of aortic biomechanics	• Requires significant modelling assumptions • High computational costs • Technical engineering expertise required to develop and run models